Liver chemistry in new-onset Henoch-Schönlein syndrome

Giulia Rosti, Gregorio P. Milani, Emanuela A. Laicini, Emilio F. Fossali, Mario G. Bianchetti

Research output: Contribution to journalArticlepeer-review


Background: Henoch-Schönlein syndrome is a systemic small-vessel leukocytoclastic vasculitis that usually present with cutaneous, gastrointestinal, articular and renal manifestations. Little is known on liver involvement in this syndrome. This study investigated liver chemistry and creatine kinase in Henoch-Schönlein children. Case presentation: Alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, lactate dehydrogenase, total bilirubin, prothrombin time and creatine kinase were assessed in 75 consecutive pediatric patients (41 boys and 34 girls aged from 2.9 to 17 years) with new-onset Henoch-Schönlein syndrome. Mildly altered values were found in 7 (9%) patients (5 boys and 2 girls aged from 3.3 to 17 years). In the mentioned cases, all tests returned to normal at a 2-4-week follow-up. Conclusions: This preliminary study points out that altered and self-remitting liver parameters occur in approximately 10% of children with Henoch-Schönlein syndrome.

Original languageEnglish
Article number85
JournalItalian Journal of Pediatrics
Issue number1
Publication statusPublished - Sep 21 2017


  • Allergic purpura
  • Diagnostic test
  • Elevated liver enzymes
  • Hepatitis
  • Vasculitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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