Liver damage in Italian patients with hereditary hemochromatosis is highly influenced by hepatitis B and C virus infection

A. Piperno, S. Fargion, R. D'Alba, L. Roffi, A. L. Fracanzani, L. Vecchi, M. Failla, G. Fiorelli

Research output: Contribution to journalArticle

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Abstract

We evaluated the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in 78 Italian patients with hereditary hemochromatosis as well as the relation between HCV antibody (anti-HCV) status, hepatitis B surface antigen (HBsAg) and liver histology. None of the patients had been transfused or ever consumed more than 60 g of alcohol per day. Eighteen showed histological signs of chronic hepatitis, active cirrhosis was present in 12, chronic active hepatitis in 4 and chronic persistent hepatitis in 2. Liver fibrosis or cirrhosis without inflammatory activity was observed in 31 subjects, whereas liver histology was normal except for iron overload in 18. The prevalence of HBsAg in the whole series was 5% and of anti-HCV was 20.5%. The prevalence of HBsAg and anti-HCV was significantly higher in the chronic hepatitis group than in the fibrosis/cirrhosis (p=0.01) and the normal groups (p

Original languageEnglish
Pages (from-to)364-368
Number of pages5
JournalJournal of Hepatology
Volume16
Issue number3
DOIs
Publication statusPublished - 1992

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Hemochromatosis
Virus Diseases
Chronic Hepatitis
Hepatitis B virus
Hepacivirus
Hepatitis B Surface Antigens
Hepatitis C Antibodies
Fibrosis
Liver
Liver Cirrhosis
Histology
Iron Overload
Alcohols

Keywords

  • Chronic hepatitis
  • HCV-RNA
  • Iron damage
  • Iron overload

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Liver damage in Italian patients with hereditary hemochromatosis is highly influenced by hepatitis B and C virus infection. / Piperno, A.; Fargion, S.; D'Alba, R.; Roffi, L.; Fracanzani, A. L.; Vecchi, L.; Failla, M.; Fiorelli, G.

In: Journal of Hepatology, Vol. 16, No. 3, 1992, p. 364-368.

Research output: Contribution to journalArticle

Piperno, A. ; Fargion, S. ; D'Alba, R. ; Roffi, L. ; Fracanzani, A. L. ; Vecchi, L. ; Failla, M. ; Fiorelli, G. / Liver damage in Italian patients with hereditary hemochromatosis is highly influenced by hepatitis B and C virus infection. In: Journal of Hepatology. 1992 ; Vol. 16, No. 3. pp. 364-368.
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