Liver damage in severely obese patients: A clinical-biochemical-morphologic study on 1,000 liver biopsies

Francesco Saverio Papadia, Giuseppe M. Marinari, Giovanni Camerini, Federica Murelli, Flavia Carlini, Cesare Stabilini, Nicola Scopinaro

Research output: Contribution to journalArticle

Abstract

Background: Preoperative clinical and biochemical data and intraoperative liver biopsy of 1,000 obese patients submitted to biliopancreatic diversion (BPD) were analyzed, and correlations investigated. Methods: Of 2,645 patients submitted to BPD between May 1976 and November 2002, the last 1,000 consecutive obese patients with no history of alcohol consumption or infectious hepatitis were selected. Clinical data included: age, body weight, BMI, waist-to-hip ratio (W/H), arterial blood pressure, serum glucose, triglycerides, cholesterol, albumin / γ-globulin ratio, total, conjugated and unconjugated bilirubin, γ-GT, alkaline phosphatase, AST, ALT, and prothrombin time. The degree of steatosis, inflammation and fibrosis on intraoperative wedge liver biopsy was determined and scored. Liver steatosis >70% and presence of bridging fibrosis were analyzed separately. Results: Mean BMI was 48 kg/m2. 263 patients had steatosis of >70%, and 79 had bridging fibrosis. Regression analysis showed an association between steatosis and AST, ALT, AST/ALT ratio, body weight, W/H, serum glucose, serum tryglicerides, BMI, γ-GT, age, and unconjugated bilirubin. Inflammation was significantly greater in older patients. Patients with bridging fibrosis had significantly higher values of serum glucose, AST, γ-GT, serum cholesterol and were significantly older. Bridging fibrosis was associated with diabetes, W/H >1, hypertension, albumin / γ-globulin ratio

Original languageEnglish
Pages (from-to)952-958
Number of pages7
JournalObesity Surgery
Volume14
Issue number7
DOIs
Publication statusPublished - Aug 2004

Keywords

  • Biliopancreatic diversion
  • Chronic liver disease
  • Diabetes
  • Hepatic steatosis
  • Morbid obesity

ASJC Scopus subject areas

  • Surgery

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  • Cite this

    Papadia, F. S., Marinari, G. M., Camerini, G., Murelli, F., Carlini, F., Stabilini, C., & Scopinaro, N. (2004). Liver damage in severely obese patients: A clinical-biochemical-morphologic study on 1,000 liver biopsies. Obesity Surgery, 14(7), 952-958. https://doi.org/10.1381/0960892041719644