Liver Elasticity in NASH Patients Evaluated with Real-Time Elastography (RTE)

Antonio Orlacchio, Francesca Bolacchi, Marco Antonicoli, Irene Coco, Elisa Costanzo, Daniela Tosti, Simona Francioso, Mario Angelico, Giovanni Simonetti

Research output: Contribution to journalArticle

Abstract

Liver elasticity as assessed by real-time elastography (RTE) has been shown to be correlated to liver fibrosis in various chronic liver diseases. The aim of our study was to assess the RTE performance in the evaluation of liver fibrosis in nonalcoholic steatohepatitis (NASH), as well as the histopathologic variables determining the eventual discordance between the RTE-predicted and the biopsy-proven fibrosis. Fifty-two consecutive biopsy proven NASH patients and 20 controls were studied. Liver tissue elasticity measurements were performed using the Hitachi EUB-8500 sonographer and the EUP-L52 Linear (3-7 MHz) probe. RTE liver tissue mean elasticity (TME) values were calculated and correlated to the histologic fibrosis, activity and steatosis scores. A decrease in TME was observed with increasing fibrosis (r = -0.75). Similarly, TME varied together consistently with steatosis (r = -0.3). In contrast, TME did not show any correlation with the severity of inflammation. Multiple regression analysis showed that fibrosis was the only variable able to significantly (p <0.0001) modify TME values. The diagnostic accuracy of TME measurement for F > 0 evaluated by AUC-ROC analysis was 0.86. The diagnostic accuracy of TME measurement for F ≥ 2 was 0.92. We suggest that RTE could be used as a complementary imaging method to evaluate liver fibrosis in NASH patients. Future studies of larger patient cohorts are necessary for the validation of the technique.

Original languageEnglish
Pages (from-to)537-544
Number of pages8
JournalUltrasound in Medicine and Biology
Volume38
Issue number4
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Elasticity Imaging Techniques
fibrosis
Elasticity
liver
elastic properties
Liver
Fibrosis
Liver Cirrhosis
Biopsy
Non-alcoholic Fatty Liver Disease
ROC Curve
Area Under Curve
Liver Diseases
regression analysis
Chronic Disease
Regression Analysis
Inflammation
evaluation
probes

Keywords

  • Liver fibrosis
  • Liver steatosis
  • Nonalcoholic steatohepatitis
  • Real-time elastography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

Liver Elasticity in NASH Patients Evaluated with Real-Time Elastography (RTE). / Orlacchio, Antonio; Bolacchi, Francesca; Antonicoli, Marco; Coco, Irene; Costanzo, Elisa; Tosti, Daniela; Francioso, Simona; Angelico, Mario; Simonetti, Giovanni.

In: Ultrasound in Medicine and Biology, Vol. 38, No. 4, 04.2012, p. 537-544.

Research output: Contribution to journalArticle

Orlacchio, A, Bolacchi, F, Antonicoli, M, Coco, I, Costanzo, E, Tosti, D, Francioso, S, Angelico, M & Simonetti, G 2012, 'Liver Elasticity in NASH Patients Evaluated with Real-Time Elastography (RTE)', Ultrasound in Medicine and Biology, vol. 38, no. 4, pp. 537-544. https://doi.org/10.1016/j.ultrasmedbio.2011.12.023
Orlacchio, Antonio ; Bolacchi, Francesca ; Antonicoli, Marco ; Coco, Irene ; Costanzo, Elisa ; Tosti, Daniela ; Francioso, Simona ; Angelico, Mario ; Simonetti, Giovanni. / Liver Elasticity in NASH Patients Evaluated with Real-Time Elastography (RTE). In: Ultrasound in Medicine and Biology. 2012 ; Vol. 38, No. 4. pp. 537-544.
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