TY - JOUR
T1 - Liver enzyme alteration
T2 - A guide for clinicians
AU - Giannini, Edoardo G.
AU - Testa, Roberto
AU - Savarino, Vincenzo
PY - 2005/2/1
Y1 - 2005/2/1
N2 - ISOLATED ALTERATIONS OF BIOCHEMICAL MARKERS OF LIVER DAMAGE in a seemingly healthy patient can present a challenge for the clinician. In this review we provide a guide to interpreting alterations to liver enzyme levels. The functional anatomy of the liver and pathophysiology of liver enzyme alteration are briefly reviewed. Using a schematic approach that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, we review abnormal enzymatic activity within the 2 subgroups, the most common causes of enzyme alteration and suggested initial investigations.
AB - ISOLATED ALTERATIONS OF BIOCHEMICAL MARKERS OF LIVER DAMAGE in a seemingly healthy patient can present a challenge for the clinician. In this review we provide a guide to interpreting alterations to liver enzyme levels. The functional anatomy of the liver and pathophysiology of liver enzyme alteration are briefly reviewed. Using a schematic approach that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, we review abnormal enzymatic activity within the 2 subgroups, the most common causes of enzyme alteration and suggested initial investigations.
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U2 - 10.1503/cmaj.1040752
DO - 10.1503/cmaj.1040752
M3 - Article
C2 - 15684121
AN - SCOPUS:13444282229
VL - 172
SP - 367
EP - 379
JO - Canadian Medical Association Journal
JF - Canadian Medical Association Journal
SN - 0008-4409
IS - 3
ER -