Liver enzyme alteration: A guide for clinicians

Research output: Contribution to journalArticlepeer-review


ISOLATED ALTERATIONS OF BIOCHEMICAL MARKERS OF LIVER DAMAGE in a seemingly healthy patient can present a challenge for the clinician. In this review we provide a guide to interpreting alterations to liver enzyme levels. The functional anatomy of the liver and pathophysiology of liver enzyme alteration are briefly reviewed. Using a schematic approach that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, we review abnormal enzymatic activity within the 2 subgroups, the most common causes of enzyme alteration and suggested initial investigations.

Original languageEnglish
Pages (from-to)367-379
Number of pages13
Issue number3
Publication statusPublished - Feb 1 2005

ASJC Scopus subject areas

  • Medicine(all)


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