Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients

Lutgarda Bozzetto, Anna Prinster, Giovanni Annuzzi, Lucia Costagliola, Anna Mangione, Alessandra Vitelli, Raffaella Mazzarella, Margaret Longobardo, Marcello Mancini, Carlo Vigorito, Gabriele Riccardi, Angela A. Rivellese

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - To evaluate the effects of qualitative dietary changes and the interaction with aerobic exercise training on liver fat content independent of weight loss in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS - With use of a factorial 2 x 2 randomized parallel-group design, 37 men and 8 women, aged 35-70 years, with type 2 diabetes in satisfactory blood glucose control on diet or diet plusmetformin treatmentwere assigned to one of the following groups for an 8-week period: 1) high-carbohydrate/high-fiber/low-glycemic index diet (CHO/fiber group), 2) high-MUFA diet (MUFA group), 3) high-carbohydrate/high- fiber/low- glycemic index diet plus physical activity program (CHO/fiber+Ex group), and 4) high-MUFA diet plus physical activity program (MUFA+Ex group). Before and after intervention, hepatic fat content was measured by 1H NMR. RESULTS - Dietary compliance was optimal and body weight remained stable in all groups. Liver fat content decreased more in MUFA (-29%) and MUFA+Ex (-25%) groups than in CHO/fiber (-4%) and CHO/fiber+Ex groups (-6%). Two-way repeated-measures ANOVA, including baseline values as covariate, showed a significant effect on liver fat content for diet (P = 0.006), with no effects for exercise training (P = 0.789) or diet-exercise interaction (P = 0.712). CONCLUSIONS - An isocaloric diet enriched in MUFA compared with a diet higher in carbohydrate and fiber was associated with a clinically relevant reduction of hepatic fat content in type 2 diabetic patients independent of an aerobic training program and should be considered for the nutritional management of hepatic steatosis in people with type 2 diabetes.

Original languageEnglish
Pages (from-to)1429-1435
Number of pages7
JournalDiabetes Care
Volume35
Issue number7
DOIs
Publication statusPublished - Jul 2012

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Fats
Diet
Liver
Exercise
Type 2 Diabetes Mellitus
Glycemic Index
Carbohydrates
Blood Glucose
Weight Loss
Analysis of Variance
Research Design
Body Weight
Education

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Bozzetto, L., Prinster, A., Annuzzi, G., Costagliola, L., Mangione, A., Vitelli, A., ... Rivellese, A. A. (2012). Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients. Diabetes Care, 35(7), 1429-1435. https://doi.org/10.2337/dc12-0033

Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients. / Bozzetto, Lutgarda; Prinster, Anna; Annuzzi, Giovanni; Costagliola, Lucia; Mangione, Anna; Vitelli, Alessandra; Mazzarella, Raffaella; Longobardo, Margaret; Mancini, Marcello; Vigorito, Carlo; Riccardi, Gabriele; Rivellese, Angela A.

In: Diabetes Care, Vol. 35, No. 7, 07.2012, p. 1429-1435.

Research output: Contribution to journalArticle

Bozzetto, L, Prinster, A, Annuzzi, G, Costagliola, L, Mangione, A, Vitelli, A, Mazzarella, R, Longobardo, M, Mancini, M, Vigorito, C, Riccardi, G & Rivellese, AA 2012, 'Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients', Diabetes Care, vol. 35, no. 7, pp. 1429-1435. https://doi.org/10.2337/dc12-0033
Bozzetto L, Prinster A, Annuzzi G, Costagliola L, Mangione A, Vitelli A et al. Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients. Diabetes Care. 2012 Jul;35(7):1429-1435. https://doi.org/10.2337/dc12-0033
Bozzetto, Lutgarda ; Prinster, Anna ; Annuzzi, Giovanni ; Costagliola, Lucia ; Mangione, Anna ; Vitelli, Alessandra ; Mazzarella, Raffaella ; Longobardo, Margaret ; Mancini, Marcello ; Vigorito, Carlo ; Riccardi, Gabriele ; Rivellese, Angela A. / Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients. In: Diabetes Care. 2012 ; Vol. 35, No. 7. pp. 1429-1435.
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abstract = "OBJECTIVE - To evaluate the effects of qualitative dietary changes and the interaction with aerobic exercise training on liver fat content independent of weight loss in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS - With use of a factorial 2 x 2 randomized parallel-group design, 37 men and 8 women, aged 35-70 years, with type 2 diabetes in satisfactory blood glucose control on diet or diet plusmetformin treatmentwere assigned to one of the following groups for an 8-week period: 1) high-carbohydrate/high-fiber/low-glycemic index diet (CHO/fiber group), 2) high-MUFA diet (MUFA group), 3) high-carbohydrate/high- fiber/low- glycemic index diet plus physical activity program (CHO/fiber+Ex group), and 4) high-MUFA diet plus physical activity program (MUFA+Ex group). Before and after intervention, hepatic fat content was measured by 1H NMR. RESULTS - Dietary compliance was optimal and body weight remained stable in all groups. Liver fat content decreased more in MUFA (-29{\%}) and MUFA+Ex (-25{\%}) groups than in CHO/fiber (-4{\%}) and CHO/fiber+Ex groups (-6{\%}). Two-way repeated-measures ANOVA, including baseline values as covariate, showed a significant effect on liver fat content for diet (P = 0.006), with no effects for exercise training (P = 0.789) or diet-exercise interaction (P = 0.712). CONCLUSIONS - An isocaloric diet enriched in MUFA compared with a diet higher in carbohydrate and fiber was associated with a clinically relevant reduction of hepatic fat content in type 2 diabetic patients independent of an aerobic training program and should be considered for the nutritional management of hepatic steatosis in people with type 2 diabetes.",
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AU - Bozzetto, Lutgarda

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AU - Costagliola, Lucia

AU - Mangione, Anna

AU - Vitelli, Alessandra

AU - Mazzarella, Raffaella

AU - Longobardo, Margaret

AU - Mancini, Marcello

AU - Vigorito, Carlo

AU - Riccardi, Gabriele

AU - Rivellese, Angela A.

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N2 - OBJECTIVE - To evaluate the effects of qualitative dietary changes and the interaction with aerobic exercise training on liver fat content independent of weight loss in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS - With use of a factorial 2 x 2 randomized parallel-group design, 37 men and 8 women, aged 35-70 years, with type 2 diabetes in satisfactory blood glucose control on diet or diet plusmetformin treatmentwere assigned to one of the following groups for an 8-week period: 1) high-carbohydrate/high-fiber/low-glycemic index diet (CHO/fiber group), 2) high-MUFA diet (MUFA group), 3) high-carbohydrate/high- fiber/low- glycemic index diet plus physical activity program (CHO/fiber+Ex group), and 4) high-MUFA diet plus physical activity program (MUFA+Ex group). Before and after intervention, hepatic fat content was measured by 1H NMR. RESULTS - Dietary compliance was optimal and body weight remained stable in all groups. Liver fat content decreased more in MUFA (-29%) and MUFA+Ex (-25%) groups than in CHO/fiber (-4%) and CHO/fiber+Ex groups (-6%). Two-way repeated-measures ANOVA, including baseline values as covariate, showed a significant effect on liver fat content for diet (P = 0.006), with no effects for exercise training (P = 0.789) or diet-exercise interaction (P = 0.712). CONCLUSIONS - An isocaloric diet enriched in MUFA compared with a diet higher in carbohydrate and fiber was associated with a clinically relevant reduction of hepatic fat content in type 2 diabetic patients independent of an aerobic training program and should be considered for the nutritional management of hepatic steatosis in people with type 2 diabetes.

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