Liver fibrosis, microbial translocation and immune activation markers in HIV and HCV infections and in HIV/HCV co-infection

Paolo Sacchi, Serena Cima, Marta Corbella, Giuditta Comolli, Antonella Chiesa, Fausto Baldanti, Catherine Klersy, Stefano Novati, Patrizia Mulatto, Mara Mariconti, Chiara Bazzocchi, Massimo Puoti, Laura Pagani, Gaetano Filice, Raffaele Bruno

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19 Citations (Scopus)

Abstract

Background: Liver fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C viruses. Aims: We investigated the correlation between liver fibrosis, immune activation and microbial translocation. Methods: This cross-sectional study included patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) mono-infections, HIV/HCV co-infection, and healthy controls (20 subjects/group). Peripheral blood was analysed to determine the levels of Forkhead box 3 (Foxp3) T cells, TGF-β1, CD14 (soluble and surface isoforms), IL-17 and bacterial translocation products. These measurements were correlated to the severity of liver fibrosis, measured with the FIB-4 score and transient elastography. Results: Foxp3T cell levels were significantly elevated in HIV mono-infected and co-infected groups (p

Original languageEnglish
Pages (from-to)218-225
Number of pages8
JournalDigestive and Liver Disease
Volume47
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

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Virus Diseases
Coinfection
Hepacivirus
Liver Cirrhosis
Biomarkers
HIV
Bacterial Translocation
Elasticity Imaging Techniques
Interleukin-17
Infection Control
Protein Isoforms
Cross-Sectional Studies
T-Lymphocytes

Keywords

  • Bacterial translocation
  • HIV immunity
  • HIV/HCV co-infection
  • Liver fibrosis

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology
  • Medicine(all)

Cite this

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abstract = "Background: Liver fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C viruses. Aims: We investigated the correlation between liver fibrosis, immune activation and microbial translocation. Methods: This cross-sectional study included patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) mono-infections, HIV/HCV co-infection, and healthy controls (20 subjects/group). Peripheral blood was analysed to determine the levels of Forkhead box 3 (Foxp3) T cells, TGF-β1, CD14 (soluble and surface isoforms), IL-17 and bacterial translocation products. These measurements were correlated to the severity of liver fibrosis, measured with the FIB-4 score and transient elastography. Results: Foxp3T cell levels were significantly elevated in HIV mono-infected and co-infected groups (p",
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T1 - Liver fibrosis, microbial translocation and immune activation markers in HIV and HCV infections and in HIV/HCV co-infection

AU - Sacchi, Paolo

AU - Cima, Serena

AU - Corbella, Marta

AU - Comolli, Giuditta

AU - Chiesa, Antonella

AU - Baldanti, Fausto

AU - Klersy, Catherine

AU - Novati, Stefano

AU - Mulatto, Patrizia

AU - Mariconti, Mara

AU - Bazzocchi, Chiara

AU - Puoti, Massimo

AU - Pagani, Laura

AU - Filice, Gaetano

AU - Bruno, Raffaele

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Background: Liver fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C viruses. Aims: We investigated the correlation between liver fibrosis, immune activation and microbial translocation. Methods: This cross-sectional study included patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) mono-infections, HIV/HCV co-infection, and healthy controls (20 subjects/group). Peripheral blood was analysed to determine the levels of Forkhead box 3 (Foxp3) T cells, TGF-β1, CD14 (soluble and surface isoforms), IL-17 and bacterial translocation products. These measurements were correlated to the severity of liver fibrosis, measured with the FIB-4 score and transient elastography. Results: Foxp3T cell levels were significantly elevated in HIV mono-infected and co-infected groups (p

AB - Background: Liver fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C viruses. Aims: We investigated the correlation between liver fibrosis, immune activation and microbial translocation. Methods: This cross-sectional study included patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) mono-infections, HIV/HCV co-infection, and healthy controls (20 subjects/group). Peripheral blood was analysed to determine the levels of Forkhead box 3 (Foxp3) T cells, TGF-β1, CD14 (soluble and surface isoforms), IL-17 and bacterial translocation products. These measurements were correlated to the severity of liver fibrosis, measured with the FIB-4 score and transient elastography. Results: Foxp3T cell levels were significantly elevated in HIV mono-infected and co-infected groups (p

KW - Bacterial translocation

KW - HIV immunity

KW - HIV/HCV co-infection

KW - Liver fibrosis

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