Liver fibrosis, microbial translocation and immune activation markers in HIV and HCV infections and in HIV/HCV co-infection

Paolo Sacchi, Serena Cima, Marta Corbella, Giuditta Comolli, Antonella Chiesa, Fausto Baldanti, Catherine Klersy, Stefano Novati, Patrizia Mulatto, Mara Mariconti, Chiara Bazzocchi, Massimo Puoti, Laura Pagani, Gaetano Filice, Raffaele Bruno

Research output: Contribution to journalArticle

Abstract

Background: Liver fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C viruses. Aims: We investigated the correlation between liver fibrosis, immune activation and microbial translocation. Methods: This cross-sectional study included patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) mono-infections, HIV/HCV co-infection, and healthy controls (20 subjects/group). Peripheral blood was analysed to determine the levels of Forkhead box 3 (Foxp3) T cells, TGF-β1, CD14 (soluble and surface isoforms), IL-17 and bacterial translocation products. These measurements were correlated to the severity of liver fibrosis, measured with the FIB-4 score and transient elastography. Results: Foxp3T cell levels were significantly elevated in HIV mono-infected and co-infected groups (p

Original languageEnglish
Pages (from-to)218-225
Number of pages8
JournalDigestive and Liver Disease
Volume47
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

    Fingerprint

Keywords

  • Bacterial translocation
  • HIV immunity
  • HIV/HCV co-infection
  • Liver fibrosis

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology
  • Medicine(all)

Cite this