TY - JOUR
T1 - Liver fibrosis progression is related to CD4 cell depletion in patients coinfected with hepatitis C virus and human immunodeficiency virus
AU - Puoti, M.
AU - Bonacini, M.
AU - Spinetti, A.
AU - Putzolu, V.
AU - Govindarajan, S.
AU - Zaltron, S.
AU - Favret, M.
AU - Callea, F.
AU - Gargiulo, F.
AU - Donato, F.
AU - Carosi, G.
AU - Roldan, E. Q.
AU - Zanini, B.
AU - Barbieri, M. C.
AU - Rossi, S.
AU - Forleo, M. A.
AU - Casari, S.
AU - Chiodera, A.
AU - Castelli, F.
AU - Milini, P.
AU - Tomasoni, L. R.
AU - Torti, C.
AU - Palvarini, L.
AU - Fausti, C.
PY - 2001
Y1 - 2001
N2 - A total of 204 patients with liver biopsy-proven hepatitis C virus (HCV) infection, 84 with and 120 without human immunodeficiency virus (HIV) coinfection, were studied, to evaluate variables possibly associated with the stage of liver fibrosis. All patients were injection drugs users, with a mean age of 32 years and an estimated duration of HCV infection of 12 years. Twenty-four patients (11%) had many fibrous septa with (5%) or without (6%) cirrhosis, 56 (27%) had few fibrous septa, and 124 (60%) had no fibrous septa. In all patients, an association was found between CD4 cell counts 3 and the presence of many fibrous septa (odds ratio, 3.2; P = .037), independent of HIV infection and other factors. These results suggest that HIV infection-induced CD4 depletion is independently associated with the severity of liver fibrosis in chronic HCV infection.
AB - A total of 204 patients with liver biopsy-proven hepatitis C virus (HCV) infection, 84 with and 120 without human immunodeficiency virus (HIV) coinfection, were studied, to evaluate variables possibly associated with the stage of liver fibrosis. All patients were injection drugs users, with a mean age of 32 years and an estimated duration of HCV infection of 12 years. Twenty-four patients (11%) had many fibrous septa with (5%) or without (6%) cirrhosis, 56 (27%) had few fibrous septa, and 124 (60%) had no fibrous septa. In all patients, an association was found between CD4 cell counts 3 and the presence of many fibrous septa (odds ratio, 3.2; P = .037), independent of HIV infection and other factors. These results suggest that HIV infection-induced CD4 depletion is independently associated with the severity of liver fibrosis in chronic HCV infection.
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U2 - 10.1086/317644
DO - 10.1086/317644
M3 - Article
C2 - 11087200
AN - SCOPUS:0035168903
VL - 183
SP - 134
EP - 137
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 1
ER -