Liver fibrosis progression is related to CD4 cell depletion in patients coinfected with hepatitis C virus and human immunodeficiency virus

M. Puoti; M. Bonacini; A. Spinetti; V. Putzolu; S. Govindarajan; S. Zaltron; M. Favret; F. Callea; F. Gargiulo; F. Donato; G. Carosi; E. Q. Roldan; B. Zanini; M. C. Barbieri; S. Rossi; M. A. Forleo; S. Casari; A. Chiodera; F. Castelli; P. Milini; L. R. Tomasoni; C. Torti; L. Palvarini; C. Fausti

doi:10.1086/317644

Liver fibrosis progression is related to CD4 cell depletion in patients coinfected with hepatitis C virus and human immunodeficiency virus

M. Puoti, M. Bonacini, A. Spinetti, V. Putzolu, S. Govindarajan, S. Zaltron, M. Favret, F. Callea, F. Gargiulo, F. Donato, G. Carosi, E. Q. Roldan, B. Zanini, M. C. Barbieri, S. Rossi, M. A. Forleo, S. Casari, A. Chiodera, F. Castelli, P. MiliniL. R. Tomasoni, C. Torti, L. Palvarini, C. Fausti

Research output: Contribution to journal › Article

Abstract

A total of 204 patients with liver biopsy-proven hepatitis C virus (HCV) infection, 84 with and 120 without human immunodeficiency virus (HIV) coinfection, were studied, to evaluate variables possibly associated with the stage of liver fibrosis. All patients were injection drugs users, with a mean age of 32 years and an estimated duration of HCV infection of 12 years. Twenty-four patients (11%) had many fibrous septa with (5%) or without (6%) cirrhosis, 56 (27%) had few fibrous septa, and 124 (60%) had no fibrous septa. In all patients, an association was found between CD4 cell counts 3 and the presence of many fibrous septa (odds ratio, 3.2; P = .037), independent of HIV infection and other factors. These results suggest that HIV infection-induced CD4 depletion is independently associated with the severity of liver fibrosis in chronic HCV infection.

Original language	English
Pages (from-to)	134-137
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	183
Issue number	1
DOIs	https://doi.org/10.1086/317644
Publication status	Published - 2001

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Immunology

Access to Document

10.1086/317644

Fingerprint Dive into the research topics of 'Liver fibrosis progression is related to CD4 cell depletion in patients coinfected with hepatitis C virus and human immunodeficiency virus'. Together they form a unique fingerprint.

Cite this

Puoti, M., Bonacini, M., Spinetti, A., Putzolu, V., Govindarajan, S., Zaltron, S., Favret, M., Callea, F., Gargiulo, F., Donato, F., Carosi, G., Roldan, E. Q., Zanini, B., Barbieri, M. C., Rossi, S., Forleo, M. A., Casari, S., Chiodera, A., Castelli, F., ... Fausti, C. (2001). Liver fibrosis progression is related to CD4 cell depletion in patients coinfected with hepatitis C virus and human immunodeficiency virus. Journal of Infectious Diseases, 183(1), 134-137. https://doi.org/10.1086/317644

Liver fibrosis progression is related to CD4 cell depletion in patients coinfected with hepatitis C virus and human immunodeficiency virus. / Puoti, M.; Bonacini, M.; Spinetti, A.; Putzolu, V.; Govindarajan, S.; Zaltron, S.; Favret, M.; Callea, F.; Gargiulo, F.; Donato, F.; Carosi, G.; Roldan, E. Q.; Zanini, B.; Barbieri, M. C.; Rossi, S.; Forleo, M. A.; Casari, S.; Chiodera, A.; Castelli, F.; Milini, P.; Tomasoni, L. R.; Torti, C.; Palvarini, L.; Fausti, C.

In: Journal of Infectious Diseases, Vol. 183, No. 1, 2001, p. 134-137.

Research output: Contribution to journal › Article

Puoti, M, Bonacini, M, Spinetti, A, Putzolu, V, Govindarajan, S, Zaltron, S, Favret, M, Callea, F, Gargiulo, F, Donato, F, Carosi, G, Roldan, EQ, Zanini, B, Barbieri, MC, Rossi, S, Forleo, MA, Casari, S, Chiodera, A, Castelli, F, Milini, P, Tomasoni, LR, Torti, C, Palvarini, L & Fausti, C 2001, 'Liver fibrosis progression is related to CD4 cell depletion in patients coinfected with hepatitis C virus and human immunodeficiency virus', Journal of Infectious Diseases, vol. 183, no. 1, pp. 134-137. https://doi.org/10.1086/317644

Puoti, M. ; Bonacini, M. ; Spinetti, A. ; Putzolu, V. ; Govindarajan, S. ; Zaltron, S. ; Favret, M. ; Callea, F. ; Gargiulo, F. ; Donato, F. ; Carosi, G. ; Roldan, E. Q. ; Zanini, B. ; Barbieri, M. C. ; Rossi, S. ; Forleo, M. A. ; Casari, S. ; Chiodera, A. ; Castelli, F. ; Milini, P. ; Tomasoni, L. R. ; Torti, C. ; Palvarini, L. ; Fausti, C. / Liver fibrosis progression is related to CD4 cell depletion in patients coinfected with hepatitis C virus and human immunodeficiency virus. In: Journal of Infectious Diseases. 2001 ; Vol. 183, No. 1. pp. 134-137.

@article{fa7efadb579a4d3b85d9711113f76af6,

title = "Liver fibrosis progression is related to CD4 cell depletion in patients coinfected with hepatitis C virus and human immunodeficiency virus",

abstract = "A total of 204 patients with liver biopsy-proven hepatitis C virus (HCV) infection, 84 with and 120 without human immunodeficiency virus (HIV) coinfection, were studied, to evaluate variables possibly associated with the stage of liver fibrosis. All patients were injection drugs users, with a mean age of 32 years and an estimated duration of HCV infection of 12 years. Twenty-four patients (11%) had many fibrous septa with (5%) or without (6%) cirrhosis, 56 (27%) had few fibrous septa, and 124 (60%) had no fibrous septa. In all patients, an association was found between CD4 cell counts 3 and the presence of many fibrous septa (odds ratio, 3.2; P = .037), independent of HIV infection and other factors. These results suggest that HIV infection-induced CD4 depletion is independently associated with the severity of liver fibrosis in chronic HCV infection.",

author = "M. Puoti and M. Bonacini and A. Spinetti and V. Putzolu and S. Govindarajan and S. Zaltron and M. Favret and F. Callea and F. Gargiulo and F. Donato and G. Carosi and Roldan, {E. Q.} and B. Zanini and Barbieri, {M. C.} and S. Rossi and Forleo, {M. A.} and S. Casari and A. Chiodera and F. Castelli and P. Milini and Tomasoni, {L. R.} and C. Torti and L. Palvarini and C. Fausti",

year = "2001",

doi = "10.1086/317644",

language = "English",

volume = "183",

pages = "134--137",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Liver fibrosis progression is related to CD4 cell depletion in patients coinfected with hepatitis C virus and human immunodeficiency virus

AU - Puoti, M.

AU - Bonacini, M.

AU - Spinetti, A.

AU - Putzolu, V.

AU - Govindarajan, S.

AU - Zaltron, S.

AU - Favret, M.

AU - Callea, F.

AU - Gargiulo, F.

AU - Donato, F.

AU - Carosi, G.

AU - Roldan, E. Q.

AU - Zanini, B.

AU - Barbieri, M. C.

AU - Rossi, S.

AU - Forleo, M. A.

AU - Casari, S.

AU - Chiodera, A.

AU - Castelli, F.

AU - Milini, P.

AU - Tomasoni, L. R.

AU - Torti, C.

AU - Palvarini, L.

AU - Fausti, C.

PY - 2001

Y1 - 2001

N2 - A total of 204 patients with liver biopsy-proven hepatitis C virus (HCV) infection, 84 with and 120 without human immunodeficiency virus (HIV) coinfection, were studied, to evaluate variables possibly associated with the stage of liver fibrosis. All patients were injection drugs users, with a mean age of 32 years and an estimated duration of HCV infection of 12 years. Twenty-four patients (11%) had many fibrous septa with (5%) or without (6%) cirrhosis, 56 (27%) had few fibrous septa, and 124 (60%) had no fibrous septa. In all patients, an association was found between CD4 cell counts 3 and the presence of many fibrous septa (odds ratio, 3.2; P = .037), independent of HIV infection and other factors. These results suggest that HIV infection-induced CD4 depletion is independently associated with the severity of liver fibrosis in chronic HCV infection.

AB - A total of 204 patients with liver biopsy-proven hepatitis C virus (HCV) infection, 84 with and 120 without human immunodeficiency virus (HIV) coinfection, were studied, to evaluate variables possibly associated with the stage of liver fibrosis. All patients were injection drugs users, with a mean age of 32 years and an estimated duration of HCV infection of 12 years. Twenty-four patients (11%) had many fibrous septa with (5%) or without (6%) cirrhosis, 56 (27%) had few fibrous septa, and 124 (60%) had no fibrous septa. In all patients, an association was found between CD4 cell counts 3 and the presence of many fibrous septa (odds ratio, 3.2; P = .037), independent of HIV infection and other factors. These results suggest that HIV infection-induced CD4 depletion is independently associated with the severity of liver fibrosis in chronic HCV infection.

UR - http://www.scopus.com/inward/record.url?scp=0035168903&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035168903&partnerID=8YFLogxK

U2 - 10.1086/317644

DO - 10.1086/317644

M3 - Article

C2 - 11087200

AN - SCOPUS:0035168903

VL - 183

SP - 134

EP - 137

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 1

ER -