Liver fibrosis progression is related to CD4 cell depletion in patients coinfected with hepatitis C virus and human immunodeficiency virus

M. Puoti, M. Bonacini, A. Spinetti, V. Putzolu, S. Govindarajan, S. Zaltron, M. Favret, F. Callea, F. Gargiulo, F. Donato, G. Carosi, E. Q. Roldan, B. Zanini, M. C. Barbieri, S. Rossi, M. A. Forleo, S. Casari, A. Chiodera, F. Castelli, P. MiliniL. R. Tomasoni, C. Torti, L. Palvarini, C. Fausti

Research output: Contribution to journalArticle

Abstract

A total of 204 patients with liver biopsy-proven hepatitis C virus (HCV) infection, 84 with and 120 without human immunodeficiency virus (HIV) coinfection, were studied, to evaluate variables possibly associated with the stage of liver fibrosis. All patients were injection drugs users, with a mean age of 32 years and an estimated duration of HCV infection of 12 years. Twenty-four patients (11%) had many fibrous septa with (5%) or without (6%) cirrhosis, 56 (27%) had few fibrous septa, and 124 (60%) had no fibrous septa. In all patients, an association was found between CD4 cell counts 3 and the presence of many fibrous septa (odds ratio, 3.2; P = .037), independent of HIV infection and other factors. These results suggest that HIV infection-induced CD4 depletion is independently associated with the severity of liver fibrosis in chronic HCV infection.

Original languageEnglish
Pages (from-to)134-137
Number of pages4
JournalJournal of Infectious Diseases
Volume183
Issue number1
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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    Puoti, M., Bonacini, M., Spinetti, A., Putzolu, V., Govindarajan, S., Zaltron, S., Favret, M., Callea, F., Gargiulo, F., Donato, F., Carosi, G., Roldan, E. Q., Zanini, B., Barbieri, M. C., Rossi, S., Forleo, M. A., Casari, S., Chiodera, A., Castelli, F., ... Fausti, C. (2001). Liver fibrosis progression is related to CD4 cell depletion in patients coinfected with hepatitis C virus and human immunodeficiency virus. Journal of Infectious Diseases, 183(1), 134-137. https://doi.org/10.1086/317644