Liver iron accumulation in chronic hepatitis C patients without HFE mutations: Relationships with histological damage, viral load and genotype and α-glutathione S-transferase levels

Edoardo Giannini, Luca Mastracci, Federica Botta, Paola Romagnoli, Alberto Fasoli, Domenico Risso, Francesca Faravelli, Paola Ceppa, Pasquale B. Lantieri, Gian Carlo Icardi, Roberto Testa

Research output: Contribution to journalArticle

Abstract

Background: Host and viral factors have been suggested as possible causative factors for the presence of liver iron accumulation in chronic hepatitis C. However, there is no agreement regarding the influence of liver iron accumulation on the biochemical and histological severity of chronic hepatitis C. Moreover, data concerning the relationships between both viral load and genotype and liver iron accumulation are scanty. Aims: To evaluate the biochemical, histological and virological assessment of a group of chronic hepatitis C patients without risk factors for iron overload, on the basis of the presence, degree and distribution of liver iron accumulation. Methods: Fifty-three chronic hepatitis C patients (34 men, 19 women; age 44 ± 11 years) with no risk factors for liver iron accumulation and showing no HFE mutations were chosen from a broader cohort of chronic hepatitis C patients. The presence, degree and distribution of liver iron accumulation were assessed using Deugnier's score. Relationships between the presence of liver iron accumulation and grading and staging were carried out separately. Hepatitis C virus RNA serum levels and viral genotype were compared in patients with or without liver iron accumulation. Alpha glutathione S-transferase serum levels were assessed in all patients. Results: Overall, liver iron accumulation was mild and was present in 19 patients (36%). It was associated with male gender (P=0.0358), and was reflected by high serum iron levels (P=0.001) and high ferritin levels (P

Original languageEnglish
Pages (from-to)1355-1361
Number of pages7
JournalEuropean Journal of Gastroenterology and Hepatology
Volume13
Issue number11
DOIs
Publication statusPublished - 2001

Keywords

  • α-glutathione S-transferase
  • Chronic hepatitis
  • Fibrosis
  • Hepatitis C virus
  • Hepatitis C virus RNA
  • Histology
  • Iron

ASJC Scopus subject areas

  • Gastroenterology

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