Liver Match, a prospective observational cohort study on liver transplantation in Italy: Study design and current practice of donor-recipient matching

Mario Angelico, Umberto Cillo, Stefano Fagiuoli, Antonio Gasbarrini, Caius Gavrila, Tania Marianelli, Alessandro Nanni Costa, Alessandra Nardi, Mario Strazzabosco, Patrizia Burra, Salvatore Agnes, Umberto Baccarani, Fulvio Calise, Michele Colledan, Oreste Cuomo, Luciano De Carlis, Matteo Donataccio, Giuseppe M. Ettorre, Giorgio E. Gerunda, Bruno GridelliLuigi Lupo, Vincenzo Mazzaferro, Antonio Pinna, Andrea Risaliti, Mauro Salizzoni, Giuseppe Tisone, Umberto Valente, Giorgio Rossi, Massimo Rossi, Fausto Zamboni

Research output: Contribution to journalArticle

Abstract

Background: The Liver Match is an observational cohort study that prospectively enrolled liver transplantations performed at 20 out of 21 Italian Transplant Centres between June 2007 and May 2009. Aim of the study is to investigate the impact of donor/recipient matching on outcomes. In this report we describe the study methodology and provide a cross-sectional description of donor and recipient characteristics and of graft allocation. Methods: Adult primary transplants performed with deceased heart-beating donors were included. Relevant information on donors and recipients, organ procurement and allocation were prospectively entered in an ad hoc database within the National Transplant Centre web-based Network. Data were blindly analysed by an independent Biostatistical Board. Results: The study enrolled 1530 donor/recipient matches. Median donor age was 56 years. Female donors (n=681, median 58, range 12-92 years) were older than males (n=849, median 53, range 2-97 years, p1.7 in 35.8%). The median cold ischaemia time was 7.3. h (≥10 in 10.6%). Median age of recipients was 54 years, and 77.7% were males. Hepatocellular carcinoma (HCC) was the most frequent indication overall (44.4%), being a coindication in roughly 1/3 of cases, followed by viral cirrhosis without HCC (28.2%) and alcoholic cirrhosis without HCC (10.2%). Hepatitis C virus infection (with or without HCC) was the most frequent etiologic factor (45.9% of the whole population and 71.4% of viral-related cirrhosis), yet hepatitis B virus infection accounted for 28.6% of viral-related cirrhosis, and HBcAb positivity was found in 49.7% of recipients. The median Model for End Stage Liver Disease (MELD) at transplant was 12 in patients with HCC and 18 in those without. Multivariate analysis showed a slight but significant inverse association between DRI and MELD at transplant. Conclusions: The deceased donor population in Italy has a high-risk profile compared to other countries, mainly due to older donor age. Almost half of the grafts are transplanted in recipients with HCC. Higher risk donors tend to be preferentially allocated to recipients with HCC, who are usually less ill and older. No other relevant allocation strategy is currently adopted at national level.

Original languageEnglish
Pages (from-to)155-164
Number of pages10
JournalDigestive and Liver Disease
Volume43
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Donor
  • Liver transplant
  • Recipient

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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    Angelico, M., Cillo, U., Fagiuoli, S., Gasbarrini, A., Gavrila, C., Marianelli, T., Costa, A. N., Nardi, A., Strazzabosco, M., Burra, P., Agnes, S., Baccarani, U., Calise, F., Colledan, M., Cuomo, O., De Carlis, L., Donataccio, M., Ettorre, G. M., Gerunda, G. E., ... Zamboni, F. (2011). Liver Match, a prospective observational cohort study on liver transplantation in Italy: Study design and current practice of donor-recipient matching. Digestive and Liver Disease, 43(2), 155-164. https://doi.org/10.1016/j.dld.2010.11.002