Liver metastases from gastric carcinoma: Report of a patient treated with adoptive immunotherapy (tumor-infiltrating lymphocytes plus interleukin-2 and subsequently local-regional lymphokine-activated killer cells plus interleukin-2)

L. Fabbri, R. Ridolfi, A. Riccobon, R. Maltoni, E. Flamini, R. Fedriga, A. Flamigni, G. Migliori, F. Ortolani, F. Calzolari, D. Amadori

Research output: Contribution to journalArticlepeer-review

Abstract

A 37-year-old patient with liver metastases from gastric cancer was treated with a double adoptive immunotherapy regimen comprising tumor-infiltrating lymphocytes plus interleukin-2 and subsequently local-regional lymphokine-activated killer cells plus interleukin-2 because of an extremely high in vitro cytotoxic specific activity on established gastric cancer cell lines. The necrosis verified in the center of the hepatic metastasis would appear to demonstrate treatment efficacy, but no clinical response was seen. In vitro cytotoxicity data alone are insufficient to predict the clinical efficacy of adoptive immunotherapy.

Original languageEnglish
Pages (from-to)445-449
Number of pages5
JournalTumori
Volume81
Issue number6
Publication statusPublished - 1995

Keywords

  • gastric cancer
  • interleukin-2
  • lymphokine-activated killer cells
  • tumor-infiltrating lymphocytes

ASJC Scopus subject areas

  • Cancer Research

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