Liver metastases in colon cancer

Lorenzo Capussotti; Luca Vigano; Francesco Leone; Delia Campanella

doi:10.1007/978-88-470-2613-1_5

Liver metastases in colon cancer

Lorenzo Capussotti, Luca Vigano, Francesco Leone, Delia Campanella

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Liver metastases are found at diagnosis in up to 25% of patients with colorectal cancer (CRC) and they appear during the first 3 years following diagnosis in another 40-50% [1]. Although liver resection is currently the only therapy producing long-term cure, at diagnosis 80% of patients are not considered to be candidates for resection because of the size, location, and extent of their disease. Radiofrequency ablation has been proposed as an alternative to surgery, but at present its effectiveness in terms of local disease control is still inferior to that of liver resection [2]. Transhepatic arterial chemoembolization (TACE) and transarterial 90Y radioembolization (TARE) are more recent techniques that have been evaluated in patients with locally advanced disease; however only preliminary data are available [3,4] and larger studies are needed to better evaluate these treatments.

Original language	English
Title of host publication	Imaging Tumor Response to Therapy
Publisher	Springer-Verlag Italia s.r.l.
Pages	77-91
Number of pages	15
ISBN (Print)	9788847026131, 9788847026124
DOIs	https://doi.org/10.1007/978-88-470-2613-1_5
Publication status	Published - Jan 1 2012

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Liver metastases are found at diagnosis in up to 25% of patients with colorectal cancer (CRC) and they appear during the first 3 years following diagnosis in another 40-50% [1]. Although liver resection is currently the only therapy producing long-term cure, at diagnosis 80% of patients are not considered to be candidates for resection because of the size, location, and extent of their disease. Radiofrequency ablation has been proposed as an alternative to surgery, but at present its effectiveness in terms of local disease control is still inferior to that of liver resection [2]. Transhepatic arterial chemoembolization (TACE) and transarterial 90Y radioembolization (TARE) are more recent techniques that have been evaluated in patients with locally advanced disease; however only preliminary data are available [3,4] and larger studies are needed to better evaluate these treatments.",

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