Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I

Kristina Schoonjans, Jean Sebastien Annicotte, Thierry Huby, Oronza A. Botrugno, Elisabeth Fayard, Yukihiko Ueda, John Chapman, Johan Auwerx

Research output: Contribution to journalArticle

Abstract

The scavenger receptor class B type I (SR-BI), which mediates selective cellular cholesterol uptake from high-density lipoproteins (HDLs), plays a key role in reverse cholesterol transport. The orphan nuclear receptor liver receptor homolog 1 (LRH-1) and SR-BI are co-expressed in liver and ovary, suggesting that LRH-1 might control the expression of SR-BI in these tissues. LRH-1 induces human and mouse SR-BI promoter activity by binding to an LRH-1 response element in the promoter. Retroviral expression of LRH-1 robustly induces SR-BI, an effect associated with histone H3 acetylation on the SR-BI promoter. The decrease in SR-BI mRNA levels in livers of LRH-1+/- animals provides in vivo evidence that LRH-1 regulates SR-BI expression. Our data demonstrate that SR-BI is an LRH-1 target gene and underscore the pivotal role of LRH-1 in reverse cholesterol transport.

Original languageEnglish
Pages (from-to)1181-1187
Number of pages7
JournalEMBO Reports
Volume3
Issue number12
DOIs
Publication statusPublished - Dec 1 2002

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

Fingerprint Dive into the research topics of 'Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I'. Together they form a unique fingerprint.

  • Cite this

    Schoonjans, K., Annicotte, J. S., Huby, T., Botrugno, O. A., Fayard, E., Ueda, Y., Chapman, J., & Auwerx, J. (2002). Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I. EMBO Reports, 3(12), 1181-1187. https://doi.org/10.1093/embo-reports/kvf238