Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I

Kristina Schoonjans, Jean Sebastien Annicotte, Thierry Huby, Oronza A. Botrugno, Elisabeth Fayard, Yukihiko Ueda, John Chapman, Johan Auwerx

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

The scavenger receptor class B type I (SR-BI), which mediates selective cellular cholesterol uptake from high-density lipoproteins (HDLs), plays a key role in reverse cholesterol transport. The orphan nuclear receptor liver receptor homolog 1 (LRH-1) and SR-BI are co-expressed in liver and ovary, suggesting that LRH-1 might control the expression of SR-BI in these tissues. LRH-1 induces human and mouse SR-BI promoter activity by binding to an LRH-1 response element in the promoter. Retroviral expression of LRH-1 robustly induces SR-BI, an effect associated with histone H3 acetylation on the SR-BI promoter. The decrease in SR-BI mRNA levels in livers of LRH-1+/- animals provides in vivo evidence that LRH-1 regulates SR-BI expression. Our data demonstrate that SR-BI is an LRH-1 target gene and underscore the pivotal role of LRH-1 in reverse cholesterol transport.

Original languageEnglish
Pages (from-to)1181-1187
Number of pages7
JournalEMBO Reports
Volume3
Issue number12
DOIs
Publication statusPublished - Dec 1 2002

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CD36 Antigens
Liver
Cholesterol
Orphan Nuclear Receptors
Acetylation
Response Elements
HDL Lipoproteins
Histones
HDL Cholesterol
Ovary
Animals
Genes

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

Cite this

Schoonjans, K., Annicotte, J. S., Huby, T., Botrugno, O. A., Fayard, E., Ueda, Y., ... Auwerx, J. (2002). Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I. EMBO Reports, 3(12), 1181-1187. https://doi.org/10.1093/embo-reports/kvf238

Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I. / Schoonjans, Kristina; Annicotte, Jean Sebastien; Huby, Thierry; Botrugno, Oronza A.; Fayard, Elisabeth; Ueda, Yukihiko; Chapman, John; Auwerx, Johan.

In: EMBO Reports, Vol. 3, No. 12, 01.12.2002, p. 1181-1187.

Research output: Contribution to journalArticle

Schoonjans, K, Annicotte, JS, Huby, T, Botrugno, OA, Fayard, E, Ueda, Y, Chapman, J & Auwerx, J 2002, 'Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I', EMBO Reports, vol. 3, no. 12, pp. 1181-1187. https://doi.org/10.1093/embo-reports/kvf238
Schoonjans, Kristina ; Annicotte, Jean Sebastien ; Huby, Thierry ; Botrugno, Oronza A. ; Fayard, Elisabeth ; Ueda, Yukihiko ; Chapman, John ; Auwerx, Johan. / Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I. In: EMBO Reports. 2002 ; Vol. 3, No. 12. pp. 1181-1187.
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