Abstract
The usefulness of surgical treatment for hepatic metastases of noncolorectal non-neuroendocrine (NCRNNE) tumors is not yet clear due to the natural history of these tumors, their frequent systemic dissemination and their histological heterogeneity. The aim of this study was to evaluate the long-term outcome of patients who underwent liver resection for NCRNNE metastases. For this purpose we retrospectively analyzed 202 patients who underwent liver resection for metastasis between January 1989 and December 2006 at the Department of Surgery of the University Hospital of Udine. Fifty-six patients underwent liver resection because of NCRNNE metastases. The preoperative assessment was based on hepatic ultrasonography and CT scan; PET was used in a few patients. All patients had intraoperative liver ultrasonography to evaluate the lesions and to define the resection. Gender, age, primary tumor site (gastrointestinal or nongastrointestinal), synchronous or metachronous metastasis, unilobar or bilobar localization, number and diameter of the lesion(s), type of resection, margin status, positive lymph nodes in the hepatoduodenal ligament, and time between surgery and diagnosis of liver metastases were evaluated as possible prognostic factors for survival. Univariate analysis showed that the location of the primary tumor and the disease-free interval since the treatment of the primary tumor were positive predictive factors for longer survival. Multivariate analysis showed that the only independent significant factor was gastrointestinal versus nongastrointestinal origin. Demographic data, the synchronous or metachronous appearance of metastases, their unilobar or bilobar location, number and size, the type of resection, the resection margin status and the involvement of lymph nodes did not prove to be prognostic factors.
| Original language | English |
|---|---|
| Pages (from-to) | 316-322 |
| Number of pages | 7 |
| Journal | Tumori |
| Volume | 97 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 2011 |
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Keywords
- Liver resection for metastasis
- Metachronous NCRNNE metastasis
- NCRNNE liver metastases
- Synchronous NCRNNE metastasis
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Liver resection for noncolorectal and nonneuroendocrine metastases : Results of a study on 56 patients at a single institution. / Bresadola, Vittorio; Rossetto, Anna; Adani, Gian Luigi; Baccarani, Umberto; Lorenzin, Dario; Favero, Alessandro; Bresadola, Fabrizio.
In: Tumori, Vol. 97, No. 3, 05.2011, p. 316-322.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Liver resection for noncolorectal and nonneuroendocrine metastases
T2 - Results of a study on 56 patients at a single institution
AU - Bresadola, Vittorio
AU - Rossetto, Anna
AU - Adani, Gian Luigi
AU - Baccarani, Umberto
AU - Lorenzin, Dario
AU - Favero, Alessandro
AU - Bresadola, Fabrizio
PY - 2011/5
Y1 - 2011/5
N2 - The usefulness of surgical treatment for hepatic metastases of noncolorectal non-neuroendocrine (NCRNNE) tumors is not yet clear due to the natural history of these tumors, their frequent systemic dissemination and their histological heterogeneity. The aim of this study was to evaluate the long-term outcome of patients who underwent liver resection for NCRNNE metastases. For this purpose we retrospectively analyzed 202 patients who underwent liver resection for metastasis between January 1989 and December 2006 at the Department of Surgery of the University Hospital of Udine. Fifty-six patients underwent liver resection because of NCRNNE metastases. The preoperative assessment was based on hepatic ultrasonography and CT scan; PET was used in a few patients. All patients had intraoperative liver ultrasonography to evaluate the lesions and to define the resection. Gender, age, primary tumor site (gastrointestinal or nongastrointestinal), synchronous or metachronous metastasis, unilobar or bilobar localization, number and diameter of the lesion(s), type of resection, margin status, positive lymph nodes in the hepatoduodenal ligament, and time between surgery and diagnosis of liver metastases were evaluated as possible prognostic factors for survival. Univariate analysis showed that the location of the primary tumor and the disease-free interval since the treatment of the primary tumor were positive predictive factors for longer survival. Multivariate analysis showed that the only independent significant factor was gastrointestinal versus nongastrointestinal origin. Demographic data, the synchronous or metachronous appearance of metastases, their unilobar or bilobar location, number and size, the type of resection, the resection margin status and the involvement of lymph nodes did not prove to be prognostic factors.
AB - The usefulness of surgical treatment for hepatic metastases of noncolorectal non-neuroendocrine (NCRNNE) tumors is not yet clear due to the natural history of these tumors, their frequent systemic dissemination and their histological heterogeneity. The aim of this study was to evaluate the long-term outcome of patients who underwent liver resection for NCRNNE metastases. For this purpose we retrospectively analyzed 202 patients who underwent liver resection for metastasis between January 1989 and December 2006 at the Department of Surgery of the University Hospital of Udine. Fifty-six patients underwent liver resection because of NCRNNE metastases. The preoperative assessment was based on hepatic ultrasonography and CT scan; PET was used in a few patients. All patients had intraoperative liver ultrasonography to evaluate the lesions and to define the resection. Gender, age, primary tumor site (gastrointestinal or nongastrointestinal), synchronous or metachronous metastasis, unilobar or bilobar localization, number and diameter of the lesion(s), type of resection, margin status, positive lymph nodes in the hepatoduodenal ligament, and time between surgery and diagnosis of liver metastases were evaluated as possible prognostic factors for survival. Univariate analysis showed that the location of the primary tumor and the disease-free interval since the treatment of the primary tumor were positive predictive factors for longer survival. Multivariate analysis showed that the only independent significant factor was gastrointestinal versus nongastrointestinal origin. Demographic data, the synchronous or metachronous appearance of metastases, their unilobar or bilobar location, number and size, the type of resection, the resection margin status and the involvement of lymph nodes did not prove to be prognostic factors.
KW - Liver resection for metastasis
KW - Metachronous NCRNNE metastasis
KW - NCRNNE liver metastases
KW - Synchronous NCRNNE metastasis
UR - http://www.scopus.com/inward/record.url?scp=79960850274&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960850274&partnerID=8YFLogxK
U2 - 10.1700/912.10028
DO - 10.1700/912.10028
M3 - Article
C2 - 21789009
AN - SCOPUS:79960850274
VL - 97
SP - 316
EP - 322
JO - Tumori
JF - Tumori
SN - 0300-8916
IS - 3
ER -