Liver resection with thrombectomy as a treatment of hepatocellular carcinoma with major vascular invasion: Results from a retrospective multicentric study

Benedetta Pesi, Alessandro Ferrero, Gianluca L. Grazi, Matteo Cescon, Nadia Russolillo, Francesca Leo, Luca Boni, Antonio D. Pinna, Lorenzo Capussotti, Giacomo Batignani

Research output: Contribution to journalArticle

Abstract

Background The role of liver resection (LR) of hepatocellular carcinoma with macroscopic vascular thrombosis (MVT) remains controversial. The aim of this study is to evaluate whether the presence of MVT should still be considered a contraindication for LR. Methods Retrospective study was carried out on 62 patients who underwent LR and thrombectomy for hepatocellular carcinoma complicated by MVT. Of the 62 patients, 15 (36.5%) had tumor thrombus (TT) in the peripheral portal vein (Vp1), 5 (12.2%) in second branch (Vp2), and 21 (51.3%) in the first branch/portal vein trunk (Vp3), while on the hepatic/cava vein side, 8 (12.9%) had TT in the main trunk of the hepatic veins (Vv2) and 3 (4.8%) had TT reaching the vena cava/right atrium (Vv3). Results Perioperative major morbidity was 14.5%, while in-hospital mortality was 4.8%. Overall, 1, 3, and 5-year survival rates were 53.3%, 30.1%, and 20%, and disease-free survival rates were 31.7%, 20.8%, and 15.6%, respectively. There were no differences in survival about the MVT localized in Vp1, Vp2, or Vp3 (P =.77), while we found a statistical trend between patients with Vv2 and Vv3 (P =.06). Conclusion Surgical resection seems to be justified in these patients, and the presence of MVT should no longer be considered an absolute contraindication for LR.

Original languageEnglish
Pages (from-to)35-44
Number of pages10
JournalAmerican Journal of Surgery
Volume210
Issue number1
DOIs
Publication statusPublished - Jul 1 2015

Keywords

  • Hepatocellular carcinoma
  • Liver resection
  • Macroscopic vascular thrombosis
  • Major vascular invasion
  • Multicentric study
  • Thrombectomy

ASJC Scopus subject areas

  • Surgery

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