Liver steatosis in juvenile obesity: Correlations with lipid profile, hepatic biochemical parameters and glycemic and insulinemic responses to an oral glucose tolerance test

G. Guzzaloni, G. Grugni, A. Minocci, D. Moro, F. Morabito

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Abstract

OBJECTIVE: The aim of this study was to evaluate liver steatosis in prepubertal and pubertal obese and the correlations with the lipid profile, the serum levels of hepatic parameters and the glycemic and insulinemic responses to an oral glucose tolerance test. SUBJECTS: 375 obese, 205 males and 170 females, Tanner pubertal stage I (n = 82), stages II-III (n = 80) and stages IV-V (n = 213). MEASUREMENTS: Body mass index (BMI), waist-hip ratio (WHR), total cholesterol and high density lipoprotein (HDL), cholesterol/HDL ratio, low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides (TGL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gGT, glycemia (G), insulinemia (IRI), fasting IRI/G ratio (FIGR), glycemic (mean blood glucose, MBG) and insulinemic (mean serum insulin, MSI) responses during a 120 min oral glucose tolerance test (OGTT), expressed as area under the curve (AUC)/120 min, pancreatic insulinemic response to glucose (IRG), and liver ultrasound scanning for assessing the degree of steatosis (moderate, severe). RESULTS: Liver steatosis was found in 33% of subjects in Tanner pubertal stage 1, 36% in stage II-III and 47% in stages IV-V. BMI and transaminases were correlated with the degree of steatosis in all pubertal stages. AST, ALT and gGT were higher in the presence of steatosis, while elevated TGL was present in late puberty only; however the increase of ALT is specific for steatosis. CONCLUSION: Juvenile obesity involves a high risk of liver steatosis associated with alterations of transaminases and lipid but not glucose metabolism. These changes are apparent even to the prepubertal stage.

Original languageEnglish
Pages (from-to)772-776
Number of pages5
JournalInternational Journal of Obesity
Volume24
Issue number6
Publication statusPublished - 2000

Fingerprint

fatty liver
Fatty Liver
Glucose Tolerance Test
Alanine Transaminase
alanine transaminase
obesity
Obesity
transaminases
Aspartate Aminotransferases
Transaminases
Lipids
aspartate transaminase
liver
blood glucose
body mass index
Liver
Body Mass Index
lipids
triacylglycerols
Glucose

Keywords

  • Insulin resistance
  • Lipid profile
  • Liver steatosis
  • Obesity
  • OGTT
  • Transaminases

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

@article{997cb33eef0d4902b2c2b1f250e43c15,
title = "Liver steatosis in juvenile obesity: Correlations with lipid profile, hepatic biochemical parameters and glycemic and insulinemic responses to an oral glucose tolerance test",
abstract = "OBJECTIVE: The aim of this study was to evaluate liver steatosis in prepubertal and pubertal obese and the correlations with the lipid profile, the serum levels of hepatic parameters and the glycemic and insulinemic responses to an oral glucose tolerance test. SUBJECTS: 375 obese, 205 males and 170 females, Tanner pubertal stage I (n = 82), stages II-III (n = 80) and stages IV-V (n = 213). MEASUREMENTS: Body mass index (BMI), waist-hip ratio (WHR), total cholesterol and high density lipoprotein (HDL), cholesterol/HDL ratio, low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides (TGL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gGT, glycemia (G), insulinemia (IRI), fasting IRI/G ratio (FIGR), glycemic (mean blood glucose, MBG) and insulinemic (mean serum insulin, MSI) responses during a 120 min oral glucose tolerance test (OGTT), expressed as area under the curve (AUC)/120 min, pancreatic insulinemic response to glucose (IRG), and liver ultrasound scanning for assessing the degree of steatosis (moderate, severe). RESULTS: Liver steatosis was found in 33{\%} of subjects in Tanner pubertal stage 1, 36{\%} in stage II-III and 47{\%} in stages IV-V. BMI and transaminases were correlated with the degree of steatosis in all pubertal stages. AST, ALT and gGT were higher in the presence of steatosis, while elevated TGL was present in late puberty only; however the increase of ALT is specific for steatosis. CONCLUSION: Juvenile obesity involves a high risk of liver steatosis associated with alterations of transaminases and lipid but not glucose metabolism. These changes are apparent even to the prepubertal stage.",
keywords = "Insulin resistance, Lipid profile, Liver steatosis, Obesity, OGTT, Transaminases",
author = "G. Guzzaloni and G. Grugni and A. Minocci and D. Moro and F. Morabito",
year = "2000",
language = "English",
volume = "24",
pages = "772--776",
journal = "International Journal of Obesity",
issn = "0307-0565",
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TY - JOUR

T1 - Liver steatosis in juvenile obesity

T2 - Correlations with lipid profile, hepatic biochemical parameters and glycemic and insulinemic responses to an oral glucose tolerance test

AU - Guzzaloni, G.

AU - Grugni, G.

AU - Minocci, A.

AU - Moro, D.

AU - Morabito, F.

PY - 2000

Y1 - 2000

N2 - OBJECTIVE: The aim of this study was to evaluate liver steatosis in prepubertal and pubertal obese and the correlations with the lipid profile, the serum levels of hepatic parameters and the glycemic and insulinemic responses to an oral glucose tolerance test. SUBJECTS: 375 obese, 205 males and 170 females, Tanner pubertal stage I (n = 82), stages II-III (n = 80) and stages IV-V (n = 213). MEASUREMENTS: Body mass index (BMI), waist-hip ratio (WHR), total cholesterol and high density lipoprotein (HDL), cholesterol/HDL ratio, low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides (TGL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gGT, glycemia (G), insulinemia (IRI), fasting IRI/G ratio (FIGR), glycemic (mean blood glucose, MBG) and insulinemic (mean serum insulin, MSI) responses during a 120 min oral glucose tolerance test (OGTT), expressed as area under the curve (AUC)/120 min, pancreatic insulinemic response to glucose (IRG), and liver ultrasound scanning for assessing the degree of steatosis (moderate, severe). RESULTS: Liver steatosis was found in 33% of subjects in Tanner pubertal stage 1, 36% in stage II-III and 47% in stages IV-V. BMI and transaminases were correlated with the degree of steatosis in all pubertal stages. AST, ALT and gGT were higher in the presence of steatosis, while elevated TGL was present in late puberty only; however the increase of ALT is specific for steatosis. CONCLUSION: Juvenile obesity involves a high risk of liver steatosis associated with alterations of transaminases and lipid but not glucose metabolism. These changes are apparent even to the prepubertal stage.

AB - OBJECTIVE: The aim of this study was to evaluate liver steatosis in prepubertal and pubertal obese and the correlations with the lipid profile, the serum levels of hepatic parameters and the glycemic and insulinemic responses to an oral glucose tolerance test. SUBJECTS: 375 obese, 205 males and 170 females, Tanner pubertal stage I (n = 82), stages II-III (n = 80) and stages IV-V (n = 213). MEASUREMENTS: Body mass index (BMI), waist-hip ratio (WHR), total cholesterol and high density lipoprotein (HDL), cholesterol/HDL ratio, low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides (TGL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gGT, glycemia (G), insulinemia (IRI), fasting IRI/G ratio (FIGR), glycemic (mean blood glucose, MBG) and insulinemic (mean serum insulin, MSI) responses during a 120 min oral glucose tolerance test (OGTT), expressed as area under the curve (AUC)/120 min, pancreatic insulinemic response to glucose (IRG), and liver ultrasound scanning for assessing the degree of steatosis (moderate, severe). RESULTS: Liver steatosis was found in 33% of subjects in Tanner pubertal stage 1, 36% in stage II-III and 47% in stages IV-V. BMI and transaminases were correlated with the degree of steatosis in all pubertal stages. AST, ALT and gGT were higher in the presence of steatosis, while elevated TGL was present in late puberty only; however the increase of ALT is specific for steatosis. CONCLUSION: Juvenile obesity involves a high risk of liver steatosis associated with alterations of transaminases and lipid but not glucose metabolism. These changes are apparent even to the prepubertal stage.

KW - Insulin resistance

KW - Lipid profile

KW - Liver steatosis

KW - Obesity

KW - OGTT

KW - Transaminases

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JO - International Journal of Obesity

JF - International Journal of Obesity

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