Liver system. IV - More on the liver micro-unit: Physics and geometry of its action

Nicola Dioguardi

Research output: Contribution to journalArticlepeer-review


The geometry of liver functional micro-units is described in the light of the immunohistologic features of human hepatocytes stained with a retinol-binding protein antibody. The stained cells were distributed into two ordered sets which provided a provisional representation of the law regulating both the motion and the alternation of the rest-work phases (homopoiesis and homorhesis configurations, respectively) which reflect bistable liver micro-unit equilibrium (auto-isodiasostasis). Oscillations between the HP and HR states generate a relaxation cycle that can be assumed to be shared by all micro-units and to be regulated by feedback mechanisms. A model illustrating the compactness of the liver's global action as a result of the activity of each micro-unit is also proposed.

Original languageEnglish
Pages (from-to)41-68
Number of pages28
JournalLa Ricerca in Clinica e in Laboratorio
Issue number1
Publication statusPublished - Jan 1991


  • Law of motion of liver action
  • Liver action compactness
  • Liver action helicoidal model
  • Liver micro-unit action
  • Liver micro-unit's relaxation cycle

ASJC Scopus subject areas

  • Clinical Biochemistry


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