Liver system. V - Activation-extintion line of cyclic hepatocyte activitie

Nicola Dioguardi, Francesco Brambilla, Mario Dell Oca Eliana Arosio, Luciano Parmeggiani

Research output: Contribution to journalArticlepeer-review


The excitation-extintion line of hepatocytes from an inert state towards the stabilization of a given activity is described. Within the cell, the switching on of any given activity is a competitive process among different activities. The process is driven by the influence field created in the environment of the Rappaport acinus by sinusoidal blood which changes its characteristics during its passage from the portal zone to the central vein. Every step of the excitation-extintion pathway follows the so-called law of autoisodiasostasis (AIS), i.e. it is characterized by an oscillatory motion between restoring (homopoiesis or HP) and working (homeorhesis or HR) states. Since the cyclical bistable equilibrium of AIS characterizes all conditions of hepatocyte activities, the AIS cycle can be defined a limit cycle.

Original languageEnglish
Pages (from-to)69-78
Number of pages10
JournalLa Ricerca in Clinica e in Laboratorio
Issue number1
Publication statusPublished - Jan 1991


  • Autoisodiasostasis limit cycle
  • Hepatocyte maturation-decay line
  • Liver micro-unit action
  • Retinol-binding protein synthesis behavior

ASJC Scopus subject areas

  • Clinical Biochemistry


Dive into the research topics of 'Liver system. V - Activation-extintion line of cyclic hepatocyte activitie'. Together they form a unique fingerprint.

Cite this