Liver system. V - Activation-extintion line of cyclic hepatocyte activitie

Nicola Dioguardi; Francesco Brambilla; Mario Dell Oca Eliana Arosio; Luciano Parmeggiani

doi:10.1007/BF02919114

Liver system. V - Activation-extintion line of cyclic hepatocyte activitie

Nicola Dioguardi, Francesco Brambilla, Mario Dell Oca Eliana Arosio, Luciano Parmeggiani

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

The excitation-extintion line of hepatocytes from an inert state towards the stabilization of a given activity is described. Within the cell, the switching on of any given activity is a competitive process among different activities. The process is driven by the influence field created in the environment of the Rappaport acinus by sinusoidal blood which changes its characteristics during its passage from the portal zone to the central vein. Every step of the excitation-extintion pathway follows the so-called law of autoisodiasostasis (AIS), i.e. it is characterized by an oscillatory motion between restoring (homopoiesis or HP) and working (homeorhesis or HR) states. Since the cyclical bistable equilibrium of AIS characterizes all conditions of hepatocyte activities, the AIS cycle can be defined a limit cycle.

Original language	English
Pages (from-to)	69-78
Number of pages	10
Journal	La Ricerca in Clinica e in Laboratorio
Volume	21
Issue number	1
DOIs	https://doi.org/10.1007/BF02919114
Publication status	Published - Jan 1991

Keywords

Autoisodiasostasis limit cycle
Hepatocyte maturation-decay line
Liver micro-unit action
Retinol-binding protein synthesis behavior

ASJC Scopus subject areas

Clinical Biochemistry

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10.1007/BF02919114

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abstract = "The excitation-extintion line of hepatocytes from an inert state towards the stabilization of a given activity is described. Within the cell, the switching on of any given activity is a competitive process among different activities. The process is driven by the influence field created in the environment of the Rappaport acinus by sinusoidal blood which changes its characteristics during its passage from the portal zone to the central vein. Every step of the excitation-extintion pathway follows the so-called law of autoisodiasostasis (AIS), i.e. it is characterized by an oscillatory motion between restoring (homopoiesis or HP) and working (homeorhesis or HR) states. Since the cyclical bistable equilibrium of AIS characterizes all conditions of hepatocyte activities, the AIS cycle can be defined a limit cycle.",

keywords = "Autoisodiasostasis limit cycle, Hepatocyte maturation-decay line, Liver micro-unit action, Retinol-binding protein synthesis behavior",

author = "Nicola Dioguardi and Francesco Brambilla and {Eliana Arosio}, {Mario Dell Oca} and Luciano Parmeggiani",

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AU - Parmeggiani, Luciano

PY - 1991/1

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Liver system. V - Activation-extintion line of cyclic hepatocyte activitie

Abstract

Keywords

ASJC Scopus subject areas

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