TY - JOUR
T1 - Liver transplantation for adenomatosis
T2 - European experience
AU - Chiche, Laurence
AU - David, Anaelle
AU - Adam, René
AU - Oliverius, M. Martin
AU - Klempnauer, Jürgen
AU - Vibert, Eric
AU - Colledan, Michele
AU - Lerut, Jan
AU - Mazzafero, V. Vincenzo
AU - Di-Sandro, Stefano
AU - Laurent, Christophe
AU - Scuderi, Vincenzo
AU - Suc, Bertrand
AU - Troisi, Roberto
AU - Bachelier, Phillipe
AU - Dumortier, Jeroˆme
AU - Gugenheim, Jean
AU - Mabrut, Jean Yves
AU - Gonzalez-Pinto, Ignacio
AU - Pruvot, François René
AU - Le-Treut, Yves Patrice
AU - Navarro, Francis
AU - Ortiz-De-Urbina, Jorge
AU - Salamé, Ephrem
AU - Spada, Marco
AU - Bioulac-Sage, Paulette
PY - 2016/4/1
Y1 - 2016/4/1
N2 - The aim of this study was to collect data from patients who underwent liver transplantation (LT) for adenomatosis; to analyze the symptoms, the characteristics of the disease, and the recipient outcomes; and to better define the role of LT in this rare indication. This retrospective multicenter study, based on data from the European Liver Transplant Registry, encompassed patients who underwent LT for adenomatosis between January 1, 1986, and July 15, 2013, in Europe. Patients with glycogen storage disease (GSD) type IA were not excluded. This study included 49 patients. Sixteen patients had GSD, and 7 had liver vascular abnormalities. The main indications for transplantation were either a suspicion of hepatocellular carcinoma (HCC; 15 patients) or a histologically proven HCC (16 patients), but only 17 had actual malignant transformation (MT) of adenomas. GSD status was similar for the 2 groups, except for age and the presence of HCC on explants (P = 0.030). Three patients with HCC on explant developed recurrence after transplantation. We obtained and studied the pathomolecular characteristics for 23 patients. In conclusion, LT should remain an extremely rare treatment for adenomatosis. Indications for transplantation primarily concern the MT of adenomas. The decision should rely on morphological data and histological evidence of MT. Additional indications should be discussed on a case-by-case basis. In this report, we propose a simplified approach to this decision-making process.
AB - The aim of this study was to collect data from patients who underwent liver transplantation (LT) for adenomatosis; to analyze the symptoms, the characteristics of the disease, and the recipient outcomes; and to better define the role of LT in this rare indication. This retrospective multicenter study, based on data from the European Liver Transplant Registry, encompassed patients who underwent LT for adenomatosis between January 1, 1986, and July 15, 2013, in Europe. Patients with glycogen storage disease (GSD) type IA were not excluded. This study included 49 patients. Sixteen patients had GSD, and 7 had liver vascular abnormalities. The main indications for transplantation were either a suspicion of hepatocellular carcinoma (HCC; 15 patients) or a histologically proven HCC (16 patients), but only 17 had actual malignant transformation (MT) of adenomas. GSD status was similar for the 2 groups, except for age and the presence of HCC on explants (P = 0.030). Three patients with HCC on explant developed recurrence after transplantation. We obtained and studied the pathomolecular characteristics for 23 patients. In conclusion, LT should remain an extremely rare treatment for adenomatosis. Indications for transplantation primarily concern the MT of adenomas. The decision should rely on morphological data and histological evidence of MT. Additional indications should be discussed on a case-by-case basis. In this report, we propose a simplified approach to this decision-making process.
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U2 - 10.1002/lt.24417
DO - 10.1002/lt.24417
M3 - Article
AN - SCOPUS:84961738523
VL - 22
SP - 516
EP - 526
JO - Liver Transplantation
JF - Liver Transplantation
SN - 1527-6465
IS - 4
ER -