Liver Transplantation for Hepatic Trauma: A Study from the European Liver Transplant Registry

Marek Krawczyk, Michal Grat, Rene Adam, Wojciech G. Polak, Jurgen Klempnauer, Antonio Pinna, Fabrizio Di Benedetto, Franco Filipponi, Norbert Senninger, Aksel Foss, Sebastian Rufián-Peña, William Bennet, Johann Pratschke, Andreas Paul, Utz Settmacher, Giorgio Rossi, Mauro Salizzoni, Carlos Fernandez-Selles, Santiago T Martínez De Rituerto, Miguel A. Gómez-BravoJacques Pirenne, Olivier Detry, Pietro E. Majno, Petr Nemec, Wolf O. Bechstein, Michael Bartels, Silvio Nadalin, Francois R. Pruvot, Darius F. Mirza, Luigi Lupo, Michele Colledan, Giuseppe Tisone, Jan Ringers, Jorge Daniel, Ramón Charco Torra, Enrique Moreno González, Rafael Bañares Cañizares, Valentin Cuervas Mons Martinez, Fernando San Juan Rodríguez, Sezai Yilmaz, Piotr Remiszewski

Research output: Contribution to journalArticle

Abstract

Background. Liver transplantation is the most extreme form of surgical management of patients with hepatic trauma, with very limited literature data supporting its use. The aim of this study was to assess the results of liver transplantation for hepatic trauma. Methods. This retrospective analysis based on European Liver Transplant Registry comprised data of 73 recipients of liver transplantation for hepatic trauma performed in 37 centers in the period between 1987 and 2013. Mortality and graft loss rates at 90 days were set as primary and secondary outcome measures, respectively. Results. Mortality and graft loss rates at 90 days were 42.5% and 46.6%, respectively. Regarding general variables, cross-clamping without extracorporeal veno-venous bypass was the only independent risk factor for both mortality (P = 0.031) and graft loss (P = 0.034). Regarding more detailed factors, grade of liver trauma exceeding IV increased the risk of mortality (P = 0.005) and graft loss (P = 0.018). Moreover, a tendency above the level of significance was observed for the negative impact of injury severity score (ISS) on mortality (P = 0.071). The optimal cutoff for ISS was 33, with sensitivity of 60.0%, specificity of 80.0%, positive predictive value of 75.0%, and negative predictive value of 66.7%. Conclusions. Liver transplantation seems to be justified in selected patients with otherwise fatal severe liver injuries, particularly in whom cross-clamping without extracorporeal bypass can be omitted. The ISS cutoff less than 33 may be useful in the selection process.

Original languageEnglish
Pages (from-to)2372-2381
Number of pages10
JournalTransplantation
Volume100
Issue number11
DOIs
Publication statusPublished - Nov 1 2016

ASJC Scopus subject areas

  • Transplantation

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    Krawczyk, M., Grat, M., Adam, R., Polak, W. G., Klempnauer, J., Pinna, A., Di Benedetto, F., Filipponi, F., Senninger, N., Foss, A., Rufián-Peña, S., Bennet, W., Pratschke, J., Paul, A., Settmacher, U., Rossi, G., Salizzoni, M., Fernandez-Selles, C., De Rituerto, S. T. M., ... Remiszewski, P. (2016). Liver Transplantation for Hepatic Trauma: A Study from the European Liver Transplant Registry. Transplantation, 100(11), 2372-2381. https://doi.org/10.1097/TP.0000000000001398