Liver Transplantation for Hepatitis B Virus Patients: Long-Term Results of Three Therapeutic Approaches

A. W. Avolio, E. Nure, M. Pompili, R. Barbarino, M. Basso, L. Caccamo, S. Magalini, S. Agnes, M. Castagneto

Research output: Contribution to journalArticlepeer-review

Abstract

The indications for liver transplantation among patients with post-hepatitis B virus (HBV)-related cirrhosis have changed over the past 35 years. We reviewed the long-term results of 47 patients treated with liver transplantation for HBV-related cirrhosis. Patients were classified into 3 groups according to the perioperative regimen. In the initial experience, no immunoprophylaxis was adopted (no-IP; n = 5). From 1988-1996, an immunoprophylaxis scheme was adopted (HBIg; n = 16). From 1997-2007, we adopted the combination of lamivudine and HBIg (LAM-HBIg; n = 26). We calculated the prevalence of serological reinfection and patient survival at 1 to 20 years, using the 3 regimens. The recurrence rate was 75% in the group of untreated patients; 30% in the HBIg group; and 9% in the LAM-HBIg group. The overall survival was 67% at 5 years, and 64% at 10 and 20 years. The long-term survival for each of the 3 therapeutic approaches, namely, for the patients who did not receive any treatment, for the HBIg group, and for the LAM-HBIg group, were 20%, 50%, and 84%, respectively. We suggest to use the LAM-HBIg combination.

Original languageEnglish
Pages (from-to)1961-1964
Number of pages4
JournalTransplantation Proceedings
Volume40
Issue number6
DOIs
Publication statusPublished - Jul 2008

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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