TY - JOUR
T1 - Liver transplantation in a child with celiac disease
AU - Pavone, Piero
AU - Gruttadauria, Salvatore
AU - Leonardi, Salvatore
AU - Sorge, Giovanni
AU - Minervini, Marta Ida
AU - Greco, Filippo
AU - La Rosa, Mario
AU - Marino, Ignazio
PY - 2005
Y1 - 2005
N2 - Recently, an atypical form of celiac disease (CD) has been identified, in which gastrointestinal symptoms are less pronounced. Other organs can be more or less severely affected, and the disease might be unrecognized and undiagnosed. In some cases, hypertransaminasemia has been indicated as the first symptom of CD in infancy. A direct relationship between liver damage and glutensensitivity has been proven by the disappearance of biochemical signs and histological lesions of the liver after the initiation of the gluten-free diet. The present case report is of a 14-year-old girl affected by CD and severe hepatic failure who underwent a liver transplant. To our knowledge, this case is the first report of liver involvement related to CD which is so severe as to require a liver transplant in a child. Because most patients with CD remain undiagnosed, and, as observed in the present report, untreated CD with subclinical hepatic involvement can lead to more serious liver disease, a more aggressive diagnostic work-up for CD in the general population is warranted.
AB - Recently, an atypical form of celiac disease (CD) has been identified, in which gastrointestinal symptoms are less pronounced. Other organs can be more or less severely affected, and the disease might be unrecognized and undiagnosed. In some cases, hypertransaminasemia has been indicated as the first symptom of CD in infancy. A direct relationship between liver damage and glutensensitivity has been proven by the disappearance of biochemical signs and histological lesions of the liver after the initiation of the gluten-free diet. The present case report is of a 14-year-old girl affected by CD and severe hepatic failure who underwent a liver transplant. To our knowledge, this case is the first report of liver involvement related to CD which is so severe as to require a liver transplant in a child. Because most patients with CD remain undiagnosed, and, as observed in the present report, untreated CD with subclinical hepatic involvement can lead to more serious liver disease, a more aggressive diagnostic work-up for CD in the general population is warranted.
KW - Celiac disease
KW - Child
KW - Liver transplantation
UR - http://www.scopus.com/inward/record.url?scp=21244451456&partnerID=8YFLogxK
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U2 - 10.1111/j.1400-1746.2005.03223.x
DO - 10.1111/j.1400-1746.2005.03223.x
M3 - Article
C2 - 15946152
AN - SCOPUS:21244451456
VL - 20
SP - 956
EP - 960
JO - Journal of Gastroenterology and Hepatology (Australia)
JF - Journal of Gastroenterology and Hepatology (Australia)
SN - 0815-9319
IS - 6
ER -