Liver transplantation in a child with celiac disease

Piero Pavone, Salvatore Gruttadauria, Salvatore Leonardi, Giovanni Sorge, Marta Ida Minervini, Filippo Greco, Mario La Rosa, Ignazio Marino

Research output: Contribution to journalArticle

Abstract

Recently, an atypical form of celiac disease (CD) has been identified, in which gastrointestinal symptoms are less pronounced. Other organs can be more or less severely affected, and the disease might be unrecognized and undiagnosed. In some cases, hypertransaminasemia has been indicated as the first symptom of CD in infancy. A direct relationship between liver damage and glutensensitivity has been proven by the disappearance of biochemical signs and histological lesions of the liver after the initiation of the gluten-free diet. The present case report is of a 14-year-old girl affected by CD and severe hepatic failure who underwent a liver transplant. To our knowledge, this case is the first report of liver involvement related to CD which is so severe as to require a liver transplant in a child. Because most patients with CD remain undiagnosed, and, as observed in the present report, untreated CD with subclinical hepatic involvement can lead to more serious liver disease, a more aggressive diagnostic work-up for CD in the general population is warranted.

Original languageEnglish
Pages (from-to)956-960
Number of pages5
JournalJournal of Gastroenterology and Hepatology
Volume20
Issue number6
DOIs
Publication statusPublished - 2005

Keywords

  • Celiac disease
  • Child
  • Liver transplantation

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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  • Cite this

    Pavone, P., Gruttadauria, S., Leonardi, S., Sorge, G., Minervini, M. I., Greco, F., La Rosa, M., & Marino, I. (2005). Liver transplantation in a child with celiac disease. Journal of Gastroenterology and Hepatology, 20(6), 956-960. https://doi.org/10.1111/j.1400-1746.2005.03223.x