Liver transplantation in alcoholic patients: Impact of an alcohol addiction unit within a liver transplant center

Giovanni Addolorato, Antonio Mirijello, Lorenzo Leggio, Anna Ferrulli, Cristina D'Angelo, Gabriele Vassallo, Anthony Cossari, Giovanni Gasbarrini, Raffaele Landolfi, Salvatore Agnes, Antonio Gasbarrini, Valeria Abbate, Ludovico Abenavoli, Mariangela Antonelli, Eleonora Annicchiarico, Alfonso W. Avolio, Marco Biolato, Chiara Campanale, Esmeralda Capristo, Fabio CaputoValentina Cesario, Marco Castagneto, Nicoletta deMatthaeis, Chantal Favale, Daniele Ferrarese, Matteo Garcovich, Francesco Frongillo, Antonio Grieco, Noemi Malandrino, Luca Miele, Alessandro Milani, Antonio Nesci, Erida Nure, Giorgio Pelecca, Gilda Pepe, Paola Pietrogiacomi, Fabrizio Pizzolante, Maurizio Pompili, Francesca Romana Ponziani, GianLudovico Rapaccini, Laura Riccardi, Emanuele Rinninella, Michele C. Santoro, Gabriele Sganga, Massimo Siciliano, Vittoria Vero, Luisa Vonghia

Research output: Contribution to journalArticle

Abstract

Background: Many concerns about liver transplantation in alcoholic patients are related to the risk of alcohol recidivism. Starting from 2002, an Alcohol Addiction Unit (AAU) was formed within the liver transplant center for the management of alcoholic patients affected by end-stage liver disease and included in the waiting list for transplantation. We evaluated retrospectively the impact of the AAU on alcohol recidivism after transplantation. The relationship between alcohol recidivism and the duration of alcohol abstinence before transplant was evaluated as well. Methods: Between 1995 and 2010, 92 cirrhotic alcoholic patients underwent liver transplantation. Clinical evaluation and management of alcohol use in these patients was provided by psychiatrists with expertise in addiction medicine not affiliated to the liver transplant center before 2002 (n = 37; group A), or by the clinical staff of the AAU within the liver transplant center starting from 2002 (n = 55; group B). Results: Group B, as compared with group A, showed a significantly lower prevalence of alcohol recidivism (16.4 vs. 35.1%; p = 0.038) and a significantly lower mortality (14.5 vs. 37.8%; p = 0.01). Furthermore, an analysis of group B patients with either ≥6 or

Original languageEnglish
Pages (from-to)1601-1608
Number of pages8
JournalAlcoholism: Clinical and Experimental Research
Volume37
Issue number9
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Alcohol Addiction Unit
  • Alcohol Dependence
  • Alcohol Recidivism
  • Alcoholism
  • Orthotopic Liver Transplantation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Fingerprint Dive into the research topics of 'Liver transplantation in alcoholic patients: Impact of an alcohol addiction unit within a liver transplant center'. Together they form a unique fingerprint.

  • Cite this

    Addolorato, G., Mirijello, A., Leggio, L., Ferrulli, A., D'Angelo, C., Vassallo, G., Cossari, A., Gasbarrini, G., Landolfi, R., Agnes, S., Gasbarrini, A., Abbate, V., Abenavoli, L., Antonelli, M., Annicchiarico, E., Avolio, A. W., Biolato, M., Campanale, C., Capristo, E., ... Vonghia, L. (2013). Liver transplantation in alcoholic patients: Impact of an alcohol addiction unit within a liver transplant center. Alcoholism: Clinical and Experimental Research, 37(9), 1601-1608. https://doi.org/10.1111/acer.12117