Liver transplantation in children less than 1 year of age

E. M. Sokal, F. Veyckemans, J. de Ville de Goyet, D. Moulin, N. Van Hoorebeeck, D. Alberti, J. P. Buts, J. Rahier, L. Van Obbergh, P. Clapuyt, M. Carlier, D. Claus, D. Latinne, B. de Hemptinne, J. B. Otte

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Abstract

Of 139 children who received an orthotopic liver transplant in our center between March 1984 and July 1989, a total of 17 patients (12%) had transplants before their first birthday (mean age 10.3 months; range 8 to 11). The mean weight was 7.3 kg (range 5.2 to 13). Nine retransplantations were performed in five children because of primary nonfunction (three children), hepatic artery thrombosis (four), or rejection (two). A reduced donor liver was used for 11 of 26 transplants. Baseline immunosuppression included cyclosporine, prednisone, and azathioprine with OKT3 or anti-thymocyte globulin for steroid-resistant rejection episodes. Survivors were discharged after a mean hospital stay of 47 days (range 22 to 87), and nonsurvivors died within a mean of 40 days (range 0 to 120). The 1 year actuarial survival rate was 64.7%, in comparison with 75.8% in the whole series. One patient died perioperatively, two died from primary nonfunction, one from adenovirus infection, two from rejection, and one from bone marrow aplasia. Eighteen rejection episodes, of which 11 were steroid resistant, occurred in 11 patients. Our series shows that liver transplantation can be successful in this age group.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalJournal of Pediatrics
Volume117
Issue number2 PART 1
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Sokal, E. M., Veyckemans, F., Goyet, J. D. V. D., Moulin, D., Hoorebeeck, N. V., Alberti, D., Buts, J. P., Rahier, J., Obbergh, L. V., Clapuyt, P., Carlier, M., Claus, D., Latinne, D., Hemptinne, B. D., & Otte, J. B. (1990). Liver transplantation in children less than 1 year of age. Journal of Pediatrics, 117(2 PART 1), 205-210. https://doi.org/10.1016/S0022-3476(05)80531-1