LIVER TRANSPLANTATION IN HEPATITIS DELTA VIRUS DISEASE

M. Rizzetto, E. Chiaberge, F. Negro, C. Di Giacomo, R. Cortesini, M. Doglia, S. Macagno, G. Verme, G. Marinucci, D. Alfani, F. Milazzo, L. R. Fassati, D. Galmarini

Research output: Contribution to journalArticlepeer-review

Abstract

Seven patients with hepatitis delta virus (HDV) cirrhosis underwent liver transplantation. In every case the HDV infection was florid but accompanied by an inactive hepatitis B virus (HBV) infection. The patients were given anti-HB surface antigen (HBsAg) serum globulins and HBV vaccine. Two patients cleared the HBsAg and the HDV, and are alive and well 14 and 15 months, respectively, after transplantation. HDV infection recurred in the other five patients: hepatitis developed in three, another died, and the fifth was re-transplanted for causes unrelated to viral hepatitis (reinfection was shown by the presence of HD antigen in the graft). Liver transplantation is feasible in patients with HDV disease but involves a high risk of HDV reinfection that cannot be predicted by the virological pattern of the native HBV infection or prevented by conventional HBV prophylaxis.

Original languageEnglish
Pages (from-to)469-471
Number of pages3
JournalLancet
Volume330
Issue number8557
DOIs
Publication statusPublished - Aug 29 1987

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'LIVER TRANSPLANTATION IN HEPATITIS DELTA VIRUS DISEASE'. Together they form a unique fingerprint.

Cite this