Liver transplantation in patients with alcoholic liver disease: A retrospective study

G.A. Vassallo, C. Tarli, M.M. Rando, C. Mosoni, A. Mirijello, A. Agyei-Nkansah, M. Antonelli, L. Sestito, G. Perotti, D. Di Giuda, S. Agnes, A. Grieco, A. Gasbarrini, G. Addolorato, V. Abbate, M.E. Ainora, E. Annicchiarico, A.W. Avolio, M. Biolato, R. CaliaN. de Matthaeis, Cristina d'Angelo, D. Ferrarese, A. Ferrulli, M. Garcovich, F. Frongillo, G. Marrone, L. Miele, E. Nure, P. Pietrogiacomi, F. Pizzolante, M. Pompili, F.R. Ponziani, G.L. Rapaccini, L. Riccardi, E. Rinninella, G. Sganga, M. Siciliano, M.A. Zocco

Research output: Contribution to journalArticle

Abstract

Aim: Alcoholic liver disease (ALD) is the most common liver disease in the Western World. Liver transplantation (LT) is the treatment for end-stage ALD. However, many transplant centers are still reluctant to transplant these patients because of the risk of alcohol relapse, recurrence of the primary liver disease and associated post-transplant complications. We examined survival rate, prevalence of primary liver disease recurrence, re-transplantation and post-transplant complications among transplanted patients for alcoholic cirrhosis compared with those transplanted for viral cirrhosis. Methods: data about patients transplanted for alcoholic and viral cirrhosis at the Gemelli Hospital from January 1995 to April 2016 were retrospectively collected. Survival rate was evaluated according to the Kaplan-Meier method. Recurrence was defined as histological evidence of primary liver disease. Data on the onset of complication, causes of death and graft failure after liver transplant were analyzed. Results: There was no statistically significant difference regarding survival rate between the two groups. Only patients transplanted for viral cirrhosis presented with primary liver disease recurrence. There was a higher rate of cancer development in patients transplanted for alcoholic cirrhosis. Cancer was the major cause of death in this population. Risk factors associated with the onset of cancer were a high MELD score at the transplant time and smoking after transplantation. Conclusion: ALD is a good indication for LT. Patients transplanted for alcoholic cirrhosis should receive regular cancer screening and should be advised against smoking. Short Summary: No difference was found between patients transplanted for alcoholic cirrhosis and viral cirrhosis in term of survival rate. Only patients transplanted for viral cirrhosis presented primary liver disease recurrence. A higher rate of cancer development was found in patients transplanted for alcoholic cirrohosis. This complication was associated with post-trasplant smoking. © The Author 2017. Medical Council on Alcohol and Oxford University Press. All rights reserved.
Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalAlcohol and Alcoholism
Volume53
Issue number2
DOIs
Publication statusPublished - 2018

Fingerprint

Alcoholic Liver Diseases
Liver
Liver Transplantation
Retrospective Studies
Alcoholic Liver Cirrhosis
Transplants
Liver Diseases
Recurrence
Fibrosis
Survival Rate
Smoking
Transplantation (surgical)
Cause of Death
Neoplasms
Transplantation
Alcohols
Western World
End Stage Liver Disease
Liver Failure
Early Detection of Cancer

Keywords

  • acute graft rejection
  • adult
  • alcohol liver cirrhosis
  • alcohol liver disease
  • artery occlusion
  • artery thrombosis
  • Article
  • cardiovascular disease
  • cause of death
  • cerebrovascular disease
  • comparative study
  • diabetes mellitus
  • digestive system disease assessment
  • female
  • graft failure
  • graft recipient
  • hematologic disease
  • hepatic artery
  • histopathology
  • human
  • infection
  • kidney disease
  • liver transplantation
  • lymphoproliferative disease
  • major clinical study
  • male
  • malignant neoplasm
  • mental disease
  • middle aged
  • portal vein thrombosis
  • postoperative period
  • prevalence
  • priority journal
  • recurrent disease
  • reoperation
  • retrospective study
  • risk factor
  • smoking
  • smoking habit
  • solid malignant neoplasm
  • survival rate
  • tobacco
  • virus infection
  • aged
  • alcohol abstinence
  • follow up
  • graft survival
  • Kaplan Meier method
  • liver cirrhosis
  • liver tumor
  • mortality
  • postoperative complication
  • procedures
  • statistics and numerical data
  • survival analysis
  • virology, Adult
  • Aged
  • Alcohol Abstinence
  • Cause of Death
  • Female
  • Follow-Up Studies
  • Graft Survival
  • Humans
  • Kaplan-Meier Estimate
  • Liver Cirrhosis
  • Liver Cirrhosis, Alcoholic
  • Liver Diseases, Alcoholic
  • Liver Neoplasms
  • Liver Transplantation
  • Male
  • Middle Aged
  • Postoperative Complications
  • Recurrence
  • Reoperation
  • Retrospective Studies
  • Survival Analysis

Cite this

Vassallo, G. A., Tarli, C., Rando, M. M., Mosoni, C., Mirijello, A., Agyei-Nkansah, A., ... Zocco, M. A. (2018). Liver transplantation in patients with alcoholic liver disease: A retrospective study. Alcohol and Alcoholism, 53(2), 151-156. https://doi.org/10.1093/alcalc/agx097

Liver transplantation in patients with alcoholic liver disease: A retrospective study. / Vassallo, G.A.; Tarli, C.; Rando, M.M.; Mosoni, C.; Mirijello, A.; Agyei-Nkansah, A.; Antonelli, M.; Sestito, L.; Perotti, G.; Di Giuda, D.; Agnes, S.; Grieco, A.; Gasbarrini, A.; Addolorato, G.; Abbate, V.; Ainora, M.E.; Annicchiarico, E.; Avolio, A.W.; Biolato, M.; Calia, R.; de Matthaeis, N.; d'Angelo, Cristina; Ferrarese, D.; Ferrulli, A.; Garcovich, M.; Frongillo, F.; Marrone, G.; Miele, L.; Nure, E.; Pietrogiacomi, P.; Pizzolante, F.; Pompili, M.; Ponziani, F.R.; Rapaccini, G.L.; Riccardi, L.; Rinninella, E.; Sganga, G.; Siciliano, M.; Zocco, M.A.

In: Alcohol and Alcoholism, Vol. 53, No. 2, 2018, p. 151-156.

Research output: Contribution to journalArticle

Vassallo, GA, Tarli, C, Rando, MM, Mosoni, C, Mirijello, A, Agyei-Nkansah, A, Antonelli, M, Sestito, L, Perotti, G, Di Giuda, D, Agnes, S, Grieco, A, Gasbarrini, A, Addolorato, G, Abbate, V, Ainora, ME, Annicchiarico, E, Avolio, AW, Biolato, M, Calia, R, de Matthaeis, N, d'Angelo, C, Ferrarese, D, Ferrulli, A, Garcovich, M, Frongillo, F, Marrone, G, Miele, L, Nure, E, Pietrogiacomi, P, Pizzolante, F, Pompili, M, Ponziani, FR, Rapaccini, GL, Riccardi, L, Rinninella, E, Sganga, G, Siciliano, M & Zocco, MA 2018, 'Liver transplantation in patients with alcoholic liver disease: A retrospective study', Alcohol and Alcoholism, vol. 53, no. 2, pp. 151-156. https://doi.org/10.1093/alcalc/agx097
Vassallo GA, Tarli C, Rando MM, Mosoni C, Mirijello A, Agyei-Nkansah A et al. Liver transplantation in patients with alcoholic liver disease: A retrospective study. Alcohol and Alcoholism. 2018;53(2):151-156. https://doi.org/10.1093/alcalc/agx097
Vassallo, G.A. ; Tarli, C. ; Rando, M.M. ; Mosoni, C. ; Mirijello, A. ; Agyei-Nkansah, A. ; Antonelli, M. ; Sestito, L. ; Perotti, G. ; Di Giuda, D. ; Agnes, S. ; Grieco, A. ; Gasbarrini, A. ; Addolorato, G. ; Abbate, V. ; Ainora, M.E. ; Annicchiarico, E. ; Avolio, A.W. ; Biolato, M. ; Calia, R. ; de Matthaeis, N. ; d'Angelo, Cristina ; Ferrarese, D. ; Ferrulli, A. ; Garcovich, M. ; Frongillo, F. ; Marrone, G. ; Miele, L. ; Nure, E. ; Pietrogiacomi, P. ; Pizzolante, F. ; Pompili, M. ; Ponziani, F.R. ; Rapaccini, G.L. ; Riccardi, L. ; Rinninella, E. ; Sganga, G. ; Siciliano, M. ; Zocco, M.A. / Liver transplantation in patients with alcoholic liver disease: A retrospective study. In: Alcohol and Alcoholism. 2018 ; Vol. 53, No. 2. pp. 151-156.
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abstract = "Aim: Alcoholic liver disease (ALD) is the most common liver disease in the Western World. Liver transplantation (LT) is the treatment for end-stage ALD. However, many transplant centers are still reluctant to transplant these patients because of the risk of alcohol relapse, recurrence of the primary liver disease and associated post-transplant complications. We examined survival rate, prevalence of primary liver disease recurrence, re-transplantation and post-transplant complications among transplanted patients for alcoholic cirrhosis compared with those transplanted for viral cirrhosis. Methods: data about patients transplanted for alcoholic and viral cirrhosis at the Gemelli Hospital from January 1995 to April 2016 were retrospectively collected. Survival rate was evaluated according to the Kaplan-Meier method. Recurrence was defined as histological evidence of primary liver disease. Data on the onset of complication, causes of death and graft failure after liver transplant were analyzed. Results: There was no statistically significant difference regarding survival rate between the two groups. Only patients transplanted for viral cirrhosis presented with primary liver disease recurrence. There was a higher rate of cancer development in patients transplanted for alcoholic cirrhosis. Cancer was the major cause of death in this population. Risk factors associated with the onset of cancer were a high MELD score at the transplant time and smoking after transplantation. Conclusion: ALD is a good indication for LT. Patients transplanted for alcoholic cirrhosis should receive regular cancer screening and should be advised against smoking. Short Summary: No difference was found between patients transplanted for alcoholic cirrhosis and viral cirrhosis in term of survival rate. Only patients transplanted for viral cirrhosis presented primary liver disease recurrence. A higher rate of cancer development was found in patients transplanted for alcoholic cirrohosis. This complication was associated with post-trasplant smoking. {\circledC} The Author 2017. Medical Council on Alcohol and Oxford University Press. All rights reserved.",
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author = "G.A. Vassallo and C. Tarli and M.M. Rando and C. Mosoni and A. Mirijello and A. Agyei-Nkansah and M. Antonelli and L. Sestito and G. Perotti and {Di Giuda}, D. and S. Agnes and A. Grieco and A. Gasbarrini and G. Addolorato and V. Abbate and M.E. Ainora and E. Annicchiarico and A.W. Avolio and M. Biolato and R. Calia and {de Matthaeis}, N. and Cristina d'Angelo and D. Ferrarese and A. Ferrulli and M. Garcovich and F. Frongillo and G. Marrone and L. Miele and E. Nure and P. Pietrogiacomi and F. Pizzolante and M. Pompili and F.R. Ponziani and G.L. Rapaccini and L. Riccardi and E. Rinninella and G. Sganga and M. Siciliano and M.A. Zocco",
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TY - JOUR

T1 - Liver transplantation in patients with alcoholic liver disease: A retrospective study

AU - Vassallo, G.A.

AU - Tarli, C.

AU - Rando, M.M.

AU - Mosoni, C.

AU - Mirijello, A.

AU - Agyei-Nkansah, A.

AU - Antonelli, M.

AU - Sestito, L.

AU - Perotti, G.

AU - Di Giuda, D.

AU - Agnes, S.

AU - Grieco, A.

AU - Gasbarrini, A.

AU - Addolorato, G.

AU - Abbate, V.

AU - Ainora, M.E.

AU - Annicchiarico, E.

AU - Avolio, A.W.

AU - Biolato, M.

AU - Calia, R.

AU - de Matthaeis, N.

AU - d'Angelo, Cristina

AU - Ferrarese, D.

AU - Ferrulli, A.

AU - Garcovich, M.

AU - Frongillo, F.

AU - Marrone, G.

AU - Miele, L.

AU - Nure, E.

AU - Pietrogiacomi, P.

AU - Pizzolante, F.

AU - Pompili, M.

AU - Ponziani, F.R.

AU - Rapaccini, G.L.

AU - Riccardi, L.

AU - Rinninella, E.

AU - Sganga, G.

AU - Siciliano, M.

AU - Zocco, M.A.

N1 - cited By 0

PY - 2018

Y1 - 2018

N2 - Aim: Alcoholic liver disease (ALD) is the most common liver disease in the Western World. Liver transplantation (LT) is the treatment for end-stage ALD. However, many transplant centers are still reluctant to transplant these patients because of the risk of alcohol relapse, recurrence of the primary liver disease and associated post-transplant complications. We examined survival rate, prevalence of primary liver disease recurrence, re-transplantation and post-transplant complications among transplanted patients for alcoholic cirrhosis compared with those transplanted for viral cirrhosis. Methods: data about patients transplanted for alcoholic and viral cirrhosis at the Gemelli Hospital from January 1995 to April 2016 were retrospectively collected. Survival rate was evaluated according to the Kaplan-Meier method. Recurrence was defined as histological evidence of primary liver disease. Data on the onset of complication, causes of death and graft failure after liver transplant were analyzed. Results: There was no statistically significant difference regarding survival rate between the two groups. Only patients transplanted for viral cirrhosis presented with primary liver disease recurrence. There was a higher rate of cancer development in patients transplanted for alcoholic cirrhosis. Cancer was the major cause of death in this population. Risk factors associated with the onset of cancer were a high MELD score at the transplant time and smoking after transplantation. Conclusion: ALD is a good indication for LT. Patients transplanted for alcoholic cirrhosis should receive regular cancer screening and should be advised against smoking. Short Summary: No difference was found between patients transplanted for alcoholic cirrhosis and viral cirrhosis in term of survival rate. Only patients transplanted for viral cirrhosis presented primary liver disease recurrence. A higher rate of cancer development was found in patients transplanted for alcoholic cirrohosis. This complication was associated with post-trasplant smoking. © The Author 2017. Medical Council on Alcohol and Oxford University Press. All rights reserved.

AB - Aim: Alcoholic liver disease (ALD) is the most common liver disease in the Western World. Liver transplantation (LT) is the treatment for end-stage ALD. However, many transplant centers are still reluctant to transplant these patients because of the risk of alcohol relapse, recurrence of the primary liver disease and associated post-transplant complications. We examined survival rate, prevalence of primary liver disease recurrence, re-transplantation and post-transplant complications among transplanted patients for alcoholic cirrhosis compared with those transplanted for viral cirrhosis. Methods: data about patients transplanted for alcoholic and viral cirrhosis at the Gemelli Hospital from January 1995 to April 2016 were retrospectively collected. Survival rate was evaluated according to the Kaplan-Meier method. Recurrence was defined as histological evidence of primary liver disease. Data on the onset of complication, causes of death and graft failure after liver transplant were analyzed. Results: There was no statistically significant difference regarding survival rate between the two groups. Only patients transplanted for viral cirrhosis presented with primary liver disease recurrence. There was a higher rate of cancer development in patients transplanted for alcoholic cirrhosis. Cancer was the major cause of death in this population. Risk factors associated with the onset of cancer were a high MELD score at the transplant time and smoking after transplantation. Conclusion: ALD is a good indication for LT. Patients transplanted for alcoholic cirrhosis should receive regular cancer screening and should be advised against smoking. Short Summary: No difference was found between patients transplanted for alcoholic cirrhosis and viral cirrhosis in term of survival rate. Only patients transplanted for viral cirrhosis presented primary liver disease recurrence. A higher rate of cancer development was found in patients transplanted for alcoholic cirrohosis. This complication was associated with post-trasplant smoking. © The Author 2017. Medical Council on Alcohol and Oxford University Press. All rights reserved.

KW - acute graft rejection

KW - adult

KW - alcohol liver cirrhosis

KW - alcohol liver disease

KW - artery occlusion

KW - artery thrombosis

KW - Article

KW - cardiovascular disease

KW - cause of death

KW - cerebrovascular disease

KW - comparative study

KW - diabetes mellitus

KW - digestive system disease assessment

KW - female

KW - graft failure

KW - graft recipient

KW - hematologic disease

KW - hepatic artery

KW - histopathology

KW - human

KW - infection

KW - kidney disease

KW - liver transplantation

KW - lymphoproliferative disease

KW - major clinical study

KW - male

KW - malignant neoplasm

KW - mental disease

KW - middle aged

KW - portal vein thrombosis

KW - postoperative period

KW - prevalence

KW - priority journal

KW - recurrent disease

KW - reoperation

KW - retrospective study

KW - risk factor

KW - smoking

KW - smoking habit

KW - solid malignant neoplasm

KW - survival rate

KW - tobacco

KW - virus infection

KW - aged

KW - alcohol abstinence

KW - follow up

KW - graft survival

KW - Kaplan Meier method

KW - liver cirrhosis

KW - liver tumor

KW - mortality

KW - postoperative complication

KW - procedures

KW - statistics and numerical data

KW - survival analysis

KW - virology, Adult

KW - Aged

KW - Alcohol Abstinence

KW - Cause of Death

KW - Female

KW - Follow-Up Studies

KW - Graft Survival

KW - Humans

KW - Kaplan-Meier Estimate

KW - Liver Cirrhosis

KW - Liver Cirrhosis, Alcoholic

KW - Liver Diseases, Alcoholic

KW - Liver Neoplasms

KW - Liver Transplantation

KW - Male

KW - Middle Aged

KW - Postoperative Complications

KW - Recurrence

KW - Reoperation

KW - Retrospective Studies

KW - Survival Analysis

U2 - 10.1093/alcalc/agx097

DO - 10.1093/alcalc/agx097

M3 - Article

VL - 53

SP - 151

EP - 156

JO - Alcohol and Alcoholism

JF - Alcohol and Alcoholism

SN - 0735-0414

IS - 2

ER -