Living Alone and Dementia Incidence: A Clinical-Based Study in People With Mild Cognitive Impairment

Giulia Grande, Davide Liborio Vetrano, Ilaria Cova, Simone Pomati, Daniele Mattavelli, Laura Maggiore, Valentina Cucumo, Roberta Ghiretti, Nicola Vanacore, Claudio Mariani, Debora Rizzuto

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Social isolation and living alone have been associated with negative outcomes, especially in the older population. We aim to investigate the effect of living alone on the development of dementia in people with mild cognitive impairment (MCI).

MATERIALS AND METHODS: In this longitudinal study, we enrolled 345 outpatients with MCI evaluated at baseline through a clinical and neuropsychological protocol. Data on living situation (living alone vs. living with someone) were also collected. The development of dementia at follow-up was the outcome of the study. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox regression analyses. Laplace regression was used to model the time-to-dementia diagnosis as a function of living situation.

RESULTS: During the follow-up time (mean [SD]: 2.8 [2.2] years), 172 (50%) participants developed dementia. After controlling for age, sex, years of education, MCI subtype, presence of comorbidities, and antidepressant therapy, people with MCI living alone were more likely to develop dementia (HR: 1.5; 95% CI: 1.1-2.1), when compared to those living with someone. In addition, participants with MCI living alone were diagnosed with dementia 1 year earlier than those living with someone ( P = .012).

CONCLUSION: Living alone increases by 50% the risk of developing dementia and anticipates by 1 year the diagnosis in people with MCI. These results, in line with findings of previous population-based studies, emphasize the pivotal role of the living situation in identifying a frailer share of the population at higher risk of dementia to which devote ad hoc assessment and care.

Original languageEnglish
Pages (from-to)107-113
Number of pages7
JournalJournal of Geriatric Psychiatry and Neurology
Volume31
Issue number3
DOIs
Publication statusPublished - May 2018

Fingerprint

Dementia
Incidence
Confidence Intervals
Social Isolation
Sex Education
Cognitive Dysfunction
Clinical Studies
Clinical Protocols
Antidepressive Agents
Population
Longitudinal Studies
Comorbidity
Outpatients
Regression Analysis
Outcome Assessment (Health Care)

Keywords

  • Aged
  • Aged, 80 and over
  • Cognitive Dysfunction/epidemiology
  • Dementia/diagnosis
  • Disease Progression
  • Female
  • Humans
  • Incidence
  • Independent Living
  • Italy/epidemiology
  • Loneliness
  • Longitudinal Studies
  • Male
  • Proportional Hazards Models
  • Risk

Cite this

Grande, G., Vetrano, D. L., Cova, I., Pomati, S., Mattavelli, D., Maggiore, L., ... Rizzuto, D. (2018). Living Alone and Dementia Incidence: A Clinical-Based Study in People With Mild Cognitive Impairment. Journal of Geriatric Psychiatry and Neurology, 31(3), 107-113. https://doi.org/10.1177/0891988718774425

Living Alone and Dementia Incidence : A Clinical-Based Study in People With Mild Cognitive Impairment. / Grande, Giulia; Vetrano, Davide Liborio; Cova, Ilaria; Pomati, Simone; Mattavelli, Daniele; Maggiore, Laura; Cucumo, Valentina; Ghiretti, Roberta; Vanacore, Nicola; Mariani, Claudio; Rizzuto, Debora.

In: Journal of Geriatric Psychiatry and Neurology, Vol. 31, No. 3, 05.2018, p. 107-113.

Research output: Contribution to journalArticle

Grande, G, Vetrano, DL, Cova, I, Pomati, S, Mattavelli, D, Maggiore, L, Cucumo, V, Ghiretti, R, Vanacore, N, Mariani, C & Rizzuto, D 2018, 'Living Alone and Dementia Incidence: A Clinical-Based Study in People With Mild Cognitive Impairment', Journal of Geriatric Psychiatry and Neurology, vol. 31, no. 3, pp. 107-113. https://doi.org/10.1177/0891988718774425
Grande, Giulia ; Vetrano, Davide Liborio ; Cova, Ilaria ; Pomati, Simone ; Mattavelli, Daniele ; Maggiore, Laura ; Cucumo, Valentina ; Ghiretti, Roberta ; Vanacore, Nicola ; Mariani, Claudio ; Rizzuto, Debora. / Living Alone and Dementia Incidence : A Clinical-Based Study in People With Mild Cognitive Impairment. In: Journal of Geriatric Psychiatry and Neurology. 2018 ; Vol. 31, No. 3. pp. 107-113.
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abstract = "INTRODUCTION: Social isolation and living alone have been associated with negative outcomes, especially in the older population. We aim to investigate the effect of living alone on the development of dementia in people with mild cognitive impairment (MCI).MATERIALS AND METHODS: In this longitudinal study, we enrolled 345 outpatients with MCI evaluated at baseline through a clinical and neuropsychological protocol. Data on living situation (living alone vs. living with someone) were also collected. The development of dementia at follow-up was the outcome of the study. Hazard ratios (HRs) with 95{\%} confidence intervals (CIs) were estimated using Cox regression analyses. Laplace regression was used to model the time-to-dementia diagnosis as a function of living situation.RESULTS: During the follow-up time (mean [SD]: 2.8 [2.2] years), 172 (50{\%}) participants developed dementia. After controlling for age, sex, years of education, MCI subtype, presence of comorbidities, and antidepressant therapy, people with MCI living alone were more likely to develop dementia (HR: 1.5; 95{\%} CI: 1.1-2.1), when compared to those living with someone. In addition, participants with MCI living alone were diagnosed with dementia 1 year earlier than those living with someone ( P = .012).CONCLUSION: Living alone increases by 50{\%} the risk of developing dementia and anticipates by 1 year the diagnosis in people with MCI. These results, in line with findings of previous population-based studies, emphasize the pivotal role of the living situation in identifying a frailer share of the population at higher risk of dementia to which devote ad hoc assessment and care.",
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T1 - Living Alone and Dementia Incidence

T2 - A Clinical-Based Study in People With Mild Cognitive Impairment

AU - Grande, Giulia

AU - Vetrano, Davide Liborio

AU - Cova, Ilaria

AU - Pomati, Simone

AU - Mattavelli, Daniele

AU - Maggiore, Laura

AU - Cucumo, Valentina

AU - Ghiretti, Roberta

AU - Vanacore, Nicola

AU - Mariani, Claudio

AU - Rizzuto, Debora

PY - 2018/5

Y1 - 2018/5

N2 - INTRODUCTION: Social isolation and living alone have been associated with negative outcomes, especially in the older population. We aim to investigate the effect of living alone on the development of dementia in people with mild cognitive impairment (MCI).MATERIALS AND METHODS: In this longitudinal study, we enrolled 345 outpatients with MCI evaluated at baseline through a clinical and neuropsychological protocol. Data on living situation (living alone vs. living with someone) were also collected. The development of dementia at follow-up was the outcome of the study. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox regression analyses. Laplace regression was used to model the time-to-dementia diagnosis as a function of living situation.RESULTS: During the follow-up time (mean [SD]: 2.8 [2.2] years), 172 (50%) participants developed dementia. After controlling for age, sex, years of education, MCI subtype, presence of comorbidities, and antidepressant therapy, people with MCI living alone were more likely to develop dementia (HR: 1.5; 95% CI: 1.1-2.1), when compared to those living with someone. In addition, participants with MCI living alone were diagnosed with dementia 1 year earlier than those living with someone ( P = .012).CONCLUSION: Living alone increases by 50% the risk of developing dementia and anticipates by 1 year the diagnosis in people with MCI. These results, in line with findings of previous population-based studies, emphasize the pivotal role of the living situation in identifying a frailer share of the population at higher risk of dementia to which devote ad hoc assessment and care.

AB - INTRODUCTION: Social isolation and living alone have been associated with negative outcomes, especially in the older population. We aim to investigate the effect of living alone on the development of dementia in people with mild cognitive impairment (MCI).MATERIALS AND METHODS: In this longitudinal study, we enrolled 345 outpatients with MCI evaluated at baseline through a clinical and neuropsychological protocol. Data on living situation (living alone vs. living with someone) were also collected. The development of dementia at follow-up was the outcome of the study. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox regression analyses. Laplace regression was used to model the time-to-dementia diagnosis as a function of living situation.RESULTS: During the follow-up time (mean [SD]: 2.8 [2.2] years), 172 (50%) participants developed dementia. After controlling for age, sex, years of education, MCI subtype, presence of comorbidities, and antidepressant therapy, people with MCI living alone were more likely to develop dementia (HR: 1.5; 95% CI: 1.1-2.1), when compared to those living with someone. In addition, participants with MCI living alone were diagnosed with dementia 1 year earlier than those living with someone ( P = .012).CONCLUSION: Living alone increases by 50% the risk of developing dementia and anticipates by 1 year the diagnosis in people with MCI. These results, in line with findings of previous population-based studies, emphasize the pivotal role of the living situation in identifying a frailer share of the population at higher risk of dementia to which devote ad hoc assessment and care.

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KW - Dementia/diagnosis

KW - Disease Progression

KW - Female

KW - Humans

KW - Incidence

KW - Independent Living

KW - Italy/epidemiology

KW - Loneliness

KW - Longitudinal Studies

KW - Male

KW - Proportional Hazards Models

KW - Risk

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DO - 10.1177/0891988718774425

M3 - Article

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JO - Journal of Geriatric Psychiatry and Neurology

JF - Journal of Geriatric Psychiatry and Neurology

SN - 0891-9887

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