Living Kidney Donation Is Recipient Age Sensitive and Has a High Rate of Donor Organ Disqualifications

M Gregorini, V Martinelli, E Ticozzelli, M Canevari, G Fasoli, E F Pattonieri, F Erasmi, M Valente, P Esposito, A Contardi, M A Grignano, A Pietrabissa, M Abelli, T Rampino

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Living donor kidney transplantation (LDKT) is the best therapy for patients with chronic renal failure. Its advantages, compared with cadaveric transplantation, include the possibility of avoiding dialysis, the likelihood of best outcome, and donor pool expansion. Careful assessment of potential donors is important to minimize the risks and ensure success. However, the proportion of donors disqualified has been poorly investigated. The aim of this work is to describe our experience and present the main reasons for missed donation.

METHODS: This was a single-center, retrospective study of all potential donors and recipients evaluated for LDKT between January 2008 and December 2017.

RESULTS: During the period of study, 81 donor-recipient pairs were evaluated. Of these, 45.7% were disqualified and 37 LDKTs were carried out. LDKT was the first choice in 68% of cases and preemptive in 20%; 60% of transplants were among family members. Sex distribution revealed a prevalence of females in the donor group (69%) and males in the recipient group (70%). The mean living donor age was 53 ± 9.5 years; the mean recipient age was lower in recipients listed in the living transplant program than those listed for cadaver transplantation (45.8 ± 13.4 vs 54.2 ± 11.08; P < .0001). Reasons for denial included hypertension (18.9%), deceased donor transplant performed during the study period (16.2%), urologic pathology (13.5%), incompatibility (13.5%), withdrawal of consent by donor or recipient (13.5%), psychological unsuitability (8.1%), donor cancer (5.4%), and reduced renal clearance (2.7%).

CONCLUSION: LDKT is considered an option especially for younger recipients. Of the potential kidney living donors, 45.7% were disqualified during the evaluation, with medical reasons being the primary cause.

Original languageEnglish
JournalTransplantation Proceedings
DOIs
Publication statusE-pub ahead of print - Jun 30 2018

Fingerprint

Living Donors
Tissue Donors
Kidney
Kidney Transplantation
Transplantation
Transplants
Sex Distribution
Cadaver
Chronic Kidney Failure
Dialysis
Retrospective Studies
Pathology
Psychology
Hypertension
Neoplasms

Cite this

@article{a5ea07ba640d4589b98373eed063913c,
title = "Living Kidney Donation Is Recipient Age Sensitive and Has a High Rate of Donor Organ Disqualifications",
abstract = "BACKGROUND: Living donor kidney transplantation (LDKT) is the best therapy for patients with chronic renal failure. Its advantages, compared with cadaveric transplantation, include the possibility of avoiding dialysis, the likelihood of best outcome, and donor pool expansion. Careful assessment of potential donors is important to minimize the risks and ensure success. However, the proportion of donors disqualified has been poorly investigated. The aim of this work is to describe our experience and present the main reasons for missed donation.METHODS: This was a single-center, retrospective study of all potential donors and recipients evaluated for LDKT between January 2008 and December 2017.RESULTS: During the period of study, 81 donor-recipient pairs were evaluated. Of these, 45.7{\%} were disqualified and 37 LDKTs were carried out. LDKT was the first choice in 68{\%} of cases and preemptive in 20{\%}; 60{\%} of transplants were among family members. Sex distribution revealed a prevalence of females in the donor group (69{\%}) and males in the recipient group (70{\%}). The mean living donor age was 53 ± 9.5 years; the mean recipient age was lower in recipients listed in the living transplant program than those listed for cadaver transplantation (45.8 ± 13.4 vs 54.2 ± 11.08; P < .0001). Reasons for denial included hypertension (18.9{\%}), deceased donor transplant performed during the study period (16.2{\%}), urologic pathology (13.5{\%}), incompatibility (13.5{\%}), withdrawal of consent by donor or recipient (13.5{\%}), psychological unsuitability (8.1{\%}), donor cancer (5.4{\%}), and reduced renal clearance (2.7{\%}).CONCLUSION: LDKT is considered an option especially for younger recipients. Of the potential kidney living donors, 45.7{\%} were disqualified during the evaluation, with medical reasons being the primary cause.",
author = "M Gregorini and V Martinelli and E Ticozzelli and M Canevari and G Fasoli and Pattonieri, {E F} and F Erasmi and M Valente and P Esposito and A Contardi and Grignano, {M A} and A Pietrabissa and M Abelli and T Rampino",
note = "Copyright {\circledC} 2018. Published by Elsevier Inc.",
year = "2018",
month = "6",
day = "30",
doi = "10.1016/j.transproceed.2018.03.136",
language = "English",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",

}

TY - JOUR

T1 - Living Kidney Donation Is Recipient Age Sensitive and Has a High Rate of Donor Organ Disqualifications

AU - Gregorini, M

AU - Martinelli, V

AU - Ticozzelli, E

AU - Canevari, M

AU - Fasoli, G

AU - Pattonieri, E F

AU - Erasmi, F

AU - Valente, M

AU - Esposito, P

AU - Contardi, A

AU - Grignano, M A

AU - Pietrabissa, A

AU - Abelli, M

AU - Rampino, T

N1 - Copyright © 2018. Published by Elsevier Inc.

PY - 2018/6/30

Y1 - 2018/6/30

N2 - BACKGROUND: Living donor kidney transplantation (LDKT) is the best therapy for patients with chronic renal failure. Its advantages, compared with cadaveric transplantation, include the possibility of avoiding dialysis, the likelihood of best outcome, and donor pool expansion. Careful assessment of potential donors is important to minimize the risks and ensure success. However, the proportion of donors disqualified has been poorly investigated. The aim of this work is to describe our experience and present the main reasons for missed donation.METHODS: This was a single-center, retrospective study of all potential donors and recipients evaluated for LDKT between January 2008 and December 2017.RESULTS: During the period of study, 81 donor-recipient pairs were evaluated. Of these, 45.7% were disqualified and 37 LDKTs were carried out. LDKT was the first choice in 68% of cases and preemptive in 20%; 60% of transplants were among family members. Sex distribution revealed a prevalence of females in the donor group (69%) and males in the recipient group (70%). The mean living donor age was 53 ± 9.5 years; the mean recipient age was lower in recipients listed in the living transplant program than those listed for cadaver transplantation (45.8 ± 13.4 vs 54.2 ± 11.08; P < .0001). Reasons for denial included hypertension (18.9%), deceased donor transplant performed during the study period (16.2%), urologic pathology (13.5%), incompatibility (13.5%), withdrawal of consent by donor or recipient (13.5%), psychological unsuitability (8.1%), donor cancer (5.4%), and reduced renal clearance (2.7%).CONCLUSION: LDKT is considered an option especially for younger recipients. Of the potential kidney living donors, 45.7% were disqualified during the evaluation, with medical reasons being the primary cause.

AB - BACKGROUND: Living donor kidney transplantation (LDKT) is the best therapy for patients with chronic renal failure. Its advantages, compared with cadaveric transplantation, include the possibility of avoiding dialysis, the likelihood of best outcome, and donor pool expansion. Careful assessment of potential donors is important to minimize the risks and ensure success. However, the proportion of donors disqualified has been poorly investigated. The aim of this work is to describe our experience and present the main reasons for missed donation.METHODS: This was a single-center, retrospective study of all potential donors and recipients evaluated for LDKT between January 2008 and December 2017.RESULTS: During the period of study, 81 donor-recipient pairs were evaluated. Of these, 45.7% were disqualified and 37 LDKTs were carried out. LDKT was the first choice in 68% of cases and preemptive in 20%; 60% of transplants were among family members. Sex distribution revealed a prevalence of females in the donor group (69%) and males in the recipient group (70%). The mean living donor age was 53 ± 9.5 years; the mean recipient age was lower in recipients listed in the living transplant program than those listed for cadaver transplantation (45.8 ± 13.4 vs 54.2 ± 11.08; P < .0001). Reasons for denial included hypertension (18.9%), deceased donor transplant performed during the study period (16.2%), urologic pathology (13.5%), incompatibility (13.5%), withdrawal of consent by donor or recipient (13.5%), psychological unsuitability (8.1%), donor cancer (5.4%), and reduced renal clearance (2.7%).CONCLUSION: LDKT is considered an option especially for younger recipients. Of the potential kidney living donors, 45.7% were disqualified during the evaluation, with medical reasons being the primary cause.

U2 - 10.1016/j.transproceed.2018.03.136

DO - 10.1016/j.transproceed.2018.03.136

M3 - Article

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

ER -