LKB1 and Tumor Metabolism: The Interplay of Immune and Angiogenic Microenvironment in Lung Cancer

Laura Bonanno, Elisabetta Zulato, Alberto Pavan, Ilaria Attili, Giulia Pasello, PierFranco Conte, Stefano Indraccolo

Research output: Contribution to journalReview articlepeer-review


Liver kinase B1 (LKB1) is a tumor suppressor gene whose inactivation is frequent in different tumor types, especially in lung adenocarcinoma (about 30% of cases). LKB1 has an essential role in the control of cellular redox homeostasis by regulating ROS production and detoxification. Loss of LKB1 makes the tumor cell more sensitive to oxidative stress and consequently to stress-inducing treatments, such as chemotherapy and radiotherapy. LKB1 loss triggers complex changes in tumor microenvironment, supporting a role in the regulation of angiogenesis and suggesting a potential role in the response to anti-angiogenic treatment. On the other hand, LKB1 deficiency can promote an immunosuppressive microenvironment and may be involved in primary resistance to anti-PD-1/anti-PD-L1, as it has been reported in lung cancer. The aim of this review is to discuss interactions of LKB1 with the tumor microenvironment and the potential applications of this knowledge in predicting response to treatment in lung cancer.

Original languageEnglish
Article number1874
Pages (from-to)1-17
Number of pages17
JournalInternational Journal of Molecular Sciences
Issue number8
Publication statusPublished - Apr 16 2019


  • Animals
  • Antineoplastic Agents/therapeutic use
  • Humans
  • Immune Tolerance/drug effects
  • Immunotherapy/methods
  • Lung/blood supply
  • Lung Neoplasms/immunology
  • Neovascularization, Pathologic/immunology
  • Protein-Serine-Threonine Kinases/immunology
  • Tumor Microenvironment/drug effects


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