LncRNA HOTAIR polymorphisms association with cancer susceptibility in different tumor types

Research output: Contribution to journalArticle

Abstract

Single nucleotide polymorphisms (SNPs) in non coding RNAs (ncRNA) molecules affect gene and protein expression and generate genetic variability influencing the risk of tumor diseases. HOTAIR is locates at the heart of the cell memory gene program and represents a prototype of long non coding RNA (LncRNA) due to its capacity to regulate in-trans a distant chromosome landscape. Aberrant expression of HOTAIR is frequently associated with pathogenesis and mostly with metastatic progression of several human cancers. Different polymorphisms, particularly present in intronic sequences, as well as in promoter regions of HOTAIR, are often associated with its aberrant expression, patient prognosis, and cancer susceptibility in different tumor phenotypes. In this minireview we have summarized the main SNPs in HOTAIR sequence and their relation with cancer risk in several types of solid tumors.

Original languageEnglish
JournalCurrent Drug Targets
DOIs
Publication statusPublished - 2018

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Long Noncoding RNA
Polymorphism
Tumors
Nucleotides
Neoplasms
Untranslated RNA
Chromosomes
Genetic Promoter Regions
Single Nucleotide Polymorphism
Genes
Data storage equipment
Molecules
Proteins
Phenotype
Gene Expression

Cite this

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title = "LncRNA HOTAIR polymorphisms association with cancer susceptibility in different tumor types",
abstract = "Single nucleotide polymorphisms (SNPs) in non coding RNAs (ncRNA) molecules affect gene and protein expression and generate genetic variability influencing the risk of tumor diseases. HOTAIR is locates at the heart of the cell memory gene program and represents a prototype of long non coding RNA (LncRNA) due to its capacity to regulate in-trans a distant chromosome landscape. Aberrant expression of HOTAIR is frequently associated with pathogenesis and mostly with metastatic progression of several human cancers. Different polymorphisms, particularly present in intronic sequences, as well as in promoter regions of HOTAIR, are often associated with its aberrant expression, patient prognosis, and cancer susceptibility in different tumor phenotypes. In this minireview we have summarized the main SNPs in HOTAIR sequence and their relation with cancer risk in several types of solid tumors.",
author = "Gerardo Botti and Francesca Collina and Giosu{\`e} Scognamiglio and Gabriella Aquino and Margherita Cerrone and Giuseppina Liguori and Vincenzo Gigantino and Malzone, {Maria Gabriella} and Monica Cantile",
note = "Copyright{\circledC} Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.",
year = "2018",
doi = "10.2174/1389450118666170622091940",
language = "English",
journal = "Current Drug Targets",
issn = "1389-4501",
publisher = "Bentham Science Publishers B.V.",

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TY - JOUR

T1 - LncRNA HOTAIR polymorphisms association with cancer susceptibility in different tumor types

AU - Botti, Gerardo

AU - Collina, Francesca

AU - Scognamiglio, Giosuè

AU - Aquino, Gabriella

AU - Cerrone, Margherita

AU - Liguori, Giuseppina

AU - Gigantino, Vincenzo

AU - Malzone, Maria Gabriella

AU - Cantile, Monica

N1 - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

PY - 2018

Y1 - 2018

N2 - Single nucleotide polymorphisms (SNPs) in non coding RNAs (ncRNA) molecules affect gene and protein expression and generate genetic variability influencing the risk of tumor diseases. HOTAIR is locates at the heart of the cell memory gene program and represents a prototype of long non coding RNA (LncRNA) due to its capacity to regulate in-trans a distant chromosome landscape. Aberrant expression of HOTAIR is frequently associated with pathogenesis and mostly with metastatic progression of several human cancers. Different polymorphisms, particularly present in intronic sequences, as well as in promoter regions of HOTAIR, are often associated with its aberrant expression, patient prognosis, and cancer susceptibility in different tumor phenotypes. In this minireview we have summarized the main SNPs in HOTAIR sequence and their relation with cancer risk in several types of solid tumors.

AB - Single nucleotide polymorphisms (SNPs) in non coding RNAs (ncRNA) molecules affect gene and protein expression and generate genetic variability influencing the risk of tumor diseases. HOTAIR is locates at the heart of the cell memory gene program and represents a prototype of long non coding RNA (LncRNA) due to its capacity to regulate in-trans a distant chromosome landscape. Aberrant expression of HOTAIR is frequently associated with pathogenesis and mostly with metastatic progression of several human cancers. Different polymorphisms, particularly present in intronic sequences, as well as in promoter regions of HOTAIR, are often associated with its aberrant expression, patient prognosis, and cancer susceptibility in different tumor phenotypes. In this minireview we have summarized the main SNPs in HOTAIR sequence and their relation with cancer risk in several types of solid tumors.

U2 - 10.2174/1389450118666170622091940

DO - 10.2174/1389450118666170622091940

M3 - Article

JO - Current Drug Targets

JF - Current Drug Targets

SN - 1389-4501

ER -