LncRNA NEAT1 in Paraspeckles: A structural scaffold for cellular DNA damage response systems?

Elisa Taiana; Domenica Ronchetti; Katia Todoerti; Lucia Nobili; Pierfrancesco Tassone; Nicola Amodio; Antonino Neri

doi:10.3390/NCRNA6030026

LncRNA NEAT1 in Paraspeckles: A structural scaffold for cellular DNA damage response systems?

Elisa Taiana, Domenica Ronchetti, Katia Todoerti, Lucia Nobili, Pierfrancesco Tassone, Nicola Amodio, Antonino Neri

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Review article › peer-review

Abstract

Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases.

Original language	English
Article number	26
Journal	Non-coding RNA
Volume	6
Issue number	3
DOIs	https://doi.org/10.3390/NCRNA6030026
Publication status	Published - Sep 1 2020

Keywords

Cancer
DNA damage repair
LncRNA
NEAT1
Neurodegenerative disease
Paraspeckle

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics

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10.3390/NCRNA6030026

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title = "LncRNA NEAT1 in Paraspeckles: A structural scaffold for cellular DNA damage response systems?",

abstract = "Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases.",

keywords = "Cancer, DNA damage repair, LncRNA, NEAT1, Neurodegenerative disease, Paraspeckle",

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T2 - A structural scaffold for cellular DNA damage response systems?

AU - Taiana, Elisa

AU - Ronchetti, Domenica

AU - Todoerti, Katia

AU - Nobili, Lucia

AU - Tassone, Pierfrancesco

AU - Amodio, Nicola

AU - Neri, Antonino

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases.

AB - Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases.

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KW - DNA damage repair

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KW - NEAT1

KW - Neurodegenerative disease

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