LncRNA NEAT1 in Paraspeckles: A structural scaffold for cellular DNA damage response systems?

Elisa Taiana, Domenica Ronchetti, Katia Todoerti, Lucia Nobili, Pierfrancesco Tassone, Nicola Amodio, Antonino Neri

Research output: Contribution to journalReview articlepeer-review

Abstract

Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases.

Original languageEnglish
Article number26
JournalNon-coding RNA
Volume6
Issue number3
DOIs
Publication statusPublished - Sep 1 2020

Keywords

  • Cancer
  • DNA damage repair
  • LncRNA
  • NEAT1
  • Neurodegenerative disease
  • Paraspeckle

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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