TY - JOUR
T1 - LncRNA NEAT1 in Paraspeckles
T2 - A structural scaffold for cellular DNA damage response systems?
AU - Taiana, Elisa
AU - Ronchetti, Domenica
AU - Todoerti, Katia
AU - Nobili, Lucia
AU - Tassone, Pierfrancesco
AU - Amodio, Nicola
AU - Neri, Antonino
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases.
AB - Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases.
KW - Cancer
KW - DNA damage repair
KW - LncRNA
KW - NEAT1
KW - Neurodegenerative disease
KW - Paraspeckle
UR - http://www.scopus.com/inward/record.url?scp=85088399693&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85088399693&partnerID=8YFLogxK
U2 - 10.3390/NCRNA6030026
DO - 10.3390/NCRNA6030026
M3 - Review article
AN - SCOPUS:85088399693
VL - 6
JO - Non-coding RNA
JF - Non-coding RNA
SN - 2311-553X
IS - 3
M1 - 26
ER -