LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients

Chiara Fenoglio, Emanuela Oldoni, Maria Serpente, Milena A. De Riz, Marina Arcaro, Marianna D'Anca, Anna M. Pietroboni, Alberto Calvi, Elisabetta Lecchi, An Goris, Klara Mallants, Bénédicte Dubois, Cristoforo Comi, Roberto Cantello, Elio Scarpini, Daniela Galimberti

Research output: Contribution to journalArticle

Abstract

LncRNA PCR arrays containing 90 common LncRNAs were used to screen lncRNA expression levels in PBMC from a discovery population of patients with MS. Data from discovery and replications cohorts showed a generalized dysregulation of lncRNA levels in MS patients compared with controls. MALAT1, MEG9, NRON, ANRIL, TUG1, XIST, SOX2OT, GOMAFU, HULC, BACE-1AS were significantly downregulated in MS patients in comparison with controls. Therefore, we performed a validation analysis in an independent cohort of Belgian origin. In this study, NRON and TUG1 downregulations in MS patients compared with controls were confirmed (p ≤.05 and p ≤.0001 respectively), whereas considering the other lncRNAs, the statistical threshold was not reached. LncRNAs profiling could thus represent a new challenge in the research of easy detectable biomarkers of disease susceptibility and progression.

Original languageEnglish
Pages (from-to)129-135
JournalJournal of Neuroimmunology
Volume324
DOIs
Publication statusPublished - 2018

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Keywords

  • Biomarker
  • Gene expression
  • Multiple Sclerosis
  • Non coding RNA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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