Local and distant control in non-metastatic pelvic Ewing's sarcoma patients

Davide Donati, Junqiang Yin, Claudia Di Bella, Marco Colangeli, Gaetano Bacci, Stefano Ferrari, Franco Bertoni, Enza Barbieri, Mario Mercuri

Research output: Contribution to journalArticle

Abstract

Background and Objectives: Due to possible complication and loss of function, surgery is not often indicated in pelvic Ewing's sarcoma (ES). The purpose of this study was to review our experience and evaluate the role of different local treatment in non-metastatic pelvic ES patients. Methods: One hundred twenty-nine patients with pelvic ES were treated at our institution between 1975 and 1999. We excluded patients presenting metastases, patients who had died of other causes, or those with incomplete clinical documentation. Among the 73 eligible patients, 17 (23%) with progression of tumor growth during induction chemotherapy eventually died. The analysis was focused on the remaining 56 patients with good or stable clinical response to the chemotherapy. Results: Patients treated with surgery, with or without radiation therapy, had a better local control (82.6% vs. 66.7%) and a significantly higher rate of 5-year EFS (73.9% vs. 30.3%, P = 0.036) than those who were only treated with local radiation therapy. Conclusion: Chemotherapy is the key factor in the treatment of pelvic ES. In our series, surgical treatment was associated with good prognosis for pelvic ES. The use of radiotherapy alone was less effective and should be only used in non-operable patients. Radiotherapy after surgery as a rescue method might not act effectively, while preoperative radiotherapy was associated with good clinical response and should be recommended.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalJournal of Surgical Oncology
Volume96
Issue number1
DOIs
Publication statusPublished - Jul 1 2007

Fingerprint

Ewing's Sarcoma
Radiotherapy
Drug Therapy
Induction Chemotherapy
Documentation
Therapeutics
Neoplasm Metastasis
Growth

Keywords

  • Ewing's sarcoma
  • Local therapy
  • Pelvis

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Donati, D., Yin, J., Di Bella, C., Colangeli, M., Bacci, G., Ferrari, S., ... Mercuri, M. (2007). Local and distant control in non-metastatic pelvic Ewing's sarcoma patients. Journal of Surgical Oncology, 96(1), 19-25. https://doi.org/10.1002/jso.20752

Local and distant control in non-metastatic pelvic Ewing's sarcoma patients. / Donati, Davide; Yin, Junqiang; Di Bella, Claudia; Colangeli, Marco; Bacci, Gaetano; Ferrari, Stefano; Bertoni, Franco; Barbieri, Enza; Mercuri, Mario.

In: Journal of Surgical Oncology, Vol. 96, No. 1, 01.07.2007, p. 19-25.

Research output: Contribution to journalArticle

Donati, D, Yin, J, Di Bella, C, Colangeli, M, Bacci, G, Ferrari, S, Bertoni, F, Barbieri, E & Mercuri, M 2007, 'Local and distant control in non-metastatic pelvic Ewing's sarcoma patients', Journal of Surgical Oncology, vol. 96, no. 1, pp. 19-25. https://doi.org/10.1002/jso.20752
Donati, Davide ; Yin, Junqiang ; Di Bella, Claudia ; Colangeli, Marco ; Bacci, Gaetano ; Ferrari, Stefano ; Bertoni, Franco ; Barbieri, Enza ; Mercuri, Mario. / Local and distant control in non-metastatic pelvic Ewing's sarcoma patients. In: Journal of Surgical Oncology. 2007 ; Vol. 96, No. 1. pp. 19-25.
@article{1858058ebe72486e891fddb05c3468ef,
title = "Local and distant control in non-metastatic pelvic Ewing's sarcoma patients",
abstract = "Background and Objectives: Due to possible complication and loss of function, surgery is not often indicated in pelvic Ewing's sarcoma (ES). The purpose of this study was to review our experience and evaluate the role of different local treatment in non-metastatic pelvic ES patients. Methods: One hundred twenty-nine patients with pelvic ES were treated at our institution between 1975 and 1999. We excluded patients presenting metastases, patients who had died of other causes, or those with incomplete clinical documentation. Among the 73 eligible patients, 17 (23{\%}) with progression of tumor growth during induction chemotherapy eventually died. The analysis was focused on the remaining 56 patients with good or stable clinical response to the chemotherapy. Results: Patients treated with surgery, with or without radiation therapy, had a better local control (82.6{\%} vs. 66.7{\%}) and a significantly higher rate of 5-year EFS (73.9{\%} vs. 30.3{\%}, P = 0.036) than those who were only treated with local radiation therapy. Conclusion: Chemotherapy is the key factor in the treatment of pelvic ES. In our series, surgical treatment was associated with good prognosis for pelvic ES. The use of radiotherapy alone was less effective and should be only used in non-operable patients. Radiotherapy after surgery as a rescue method might not act effectively, while preoperative radiotherapy was associated with good clinical response and should be recommended.",
keywords = "Ewing's sarcoma, Local therapy, Pelvis",
author = "Davide Donati and Junqiang Yin and {Di Bella}, Claudia and Marco Colangeli and Gaetano Bacci and Stefano Ferrari and Franco Bertoni and Enza Barbieri and Mario Mercuri",
year = "2007",
month = "7",
day = "1",
doi = "10.1002/jso.20752",
language = "English",
volume = "96",
pages = "19--25",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Local and distant control in non-metastatic pelvic Ewing's sarcoma patients

AU - Donati, Davide

AU - Yin, Junqiang

AU - Di Bella, Claudia

AU - Colangeli, Marco

AU - Bacci, Gaetano

AU - Ferrari, Stefano

AU - Bertoni, Franco

AU - Barbieri, Enza

AU - Mercuri, Mario

PY - 2007/7/1

Y1 - 2007/7/1

N2 - Background and Objectives: Due to possible complication and loss of function, surgery is not often indicated in pelvic Ewing's sarcoma (ES). The purpose of this study was to review our experience and evaluate the role of different local treatment in non-metastatic pelvic ES patients. Methods: One hundred twenty-nine patients with pelvic ES were treated at our institution between 1975 and 1999. We excluded patients presenting metastases, patients who had died of other causes, or those with incomplete clinical documentation. Among the 73 eligible patients, 17 (23%) with progression of tumor growth during induction chemotherapy eventually died. The analysis was focused on the remaining 56 patients with good or stable clinical response to the chemotherapy. Results: Patients treated with surgery, with or without radiation therapy, had a better local control (82.6% vs. 66.7%) and a significantly higher rate of 5-year EFS (73.9% vs. 30.3%, P = 0.036) than those who were only treated with local radiation therapy. Conclusion: Chemotherapy is the key factor in the treatment of pelvic ES. In our series, surgical treatment was associated with good prognosis for pelvic ES. The use of radiotherapy alone was less effective and should be only used in non-operable patients. Radiotherapy after surgery as a rescue method might not act effectively, while preoperative radiotherapy was associated with good clinical response and should be recommended.

AB - Background and Objectives: Due to possible complication and loss of function, surgery is not often indicated in pelvic Ewing's sarcoma (ES). The purpose of this study was to review our experience and evaluate the role of different local treatment in non-metastatic pelvic ES patients. Methods: One hundred twenty-nine patients with pelvic ES were treated at our institution between 1975 and 1999. We excluded patients presenting metastases, patients who had died of other causes, or those with incomplete clinical documentation. Among the 73 eligible patients, 17 (23%) with progression of tumor growth during induction chemotherapy eventually died. The analysis was focused on the remaining 56 patients with good or stable clinical response to the chemotherapy. Results: Patients treated with surgery, with or without radiation therapy, had a better local control (82.6% vs. 66.7%) and a significantly higher rate of 5-year EFS (73.9% vs. 30.3%, P = 0.036) than those who were only treated with local radiation therapy. Conclusion: Chemotherapy is the key factor in the treatment of pelvic ES. In our series, surgical treatment was associated with good prognosis for pelvic ES. The use of radiotherapy alone was less effective and should be only used in non-operable patients. Radiotherapy after surgery as a rescue method might not act effectively, while preoperative radiotherapy was associated with good clinical response and should be recommended.

KW - Ewing's sarcoma

KW - Local therapy

KW - Pelvis

UR - http://www.scopus.com/inward/record.url?scp=34347357420&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34347357420&partnerID=8YFLogxK

U2 - 10.1002/jso.20752

DO - 10.1002/jso.20752

M3 - Article

C2 - 17345611

AN - SCOPUS:34347357420

VL - 96

SP - 19

EP - 25

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 1

ER -