Local anesthetic versus forced coughing at colposcopic-guided biopsy: A prospective study

Giorgio Bogani, Maurizio Serati, Antonella Cromi, Edoardo Di Naro, Jvan Casarin, Ciro Pinelli, Thomas Rossi, Fabio Ghezzi

Research output: Contribution to journalArticlepeer-review


Objective: To evaluate whether the administration of local anesthetic (LA) reduces pain in comparison with forced coughing (FC) for the execution of colposcopically guided biopsies (CGBs).

Study design: Data of 100 consecutive patients undergoing CGBs with the use of LA or FC were prospectively evaluated. Procedure-related pain was assessed with the use of a 100-mm visual analogue scale.

Results: Fifty-one and 49 patients had CGBs using LA and FC, respectively. No between-group differences were observed in terms of pain related to speculum insertion, CGBs and pain recorded after the procedures (p > 0.05). However, patients in the LA group experienced pain related to cervical injection for administration of anesthesia (mean (±SD): 12.4 (±1.6)). Operative time was longer in the LA than in the FC group (7.2 (±0.2) vs. 5.0 (±0.1) min; p <0.001).

Conclusions: FC should be preferred over LA. Although CGB-related pain levels do not differ, the omission of intracervical injection is associated with undoubted advantages.

Original languageEnglish
Pages (from-to)15-19
Number of pages5
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Publication statusPublished - Oct 1 2014


  • Cervical biopsy
  • Cervical dysplasia
  • Colposcopy
  • Forced coughing
  • Local anesthesia

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Medicine(all)


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