Abstract
In rats bearing unilateral 6-hydroxydopamine (6-OHDA) lesions of the dopaminergic nigro-striatal neurons, a single administration of a D-2 agonist (LY 17155) potentiates the contralateral turning induced by a D-1 agonist (SKF 38393). To identify the neural substrate of this form of sensitization (priming), we studied the local cerebral glucose utilization (lCMR(glc)) in 6-OHDA lesioned animals treated, 3 days apart, as follows: (1) saline- saline, (2) LY 171555-saline, (3) saline-SKF 38393 and (4) LY 171555-SKF 38393. The unilateral 6-OHDA lesion per se (Sal-Sal) produced increases in lCMR(glc) in the globus pallidus (GP) and in the lateral habenula (LH) of the lesioned hemisphere. lCMR(glc) in LY-Sal group were similar to those measured in the Sal-Sal group. Administration of SKF 38393 to drug-naive rats (Sal- SKF) abolished the lesion-induced metabolic asymmetry in the LH but did not have any effect on the GP; furthermore, it increased lCMR(glc) in the substantia nigra pars reticulata (SNr) of the lesioned side. After priming with LY 171555, administration of SKF 38393 (LY-SKF) produced marked metabolic asymmetries by increasing lCMR(glc) in the SNr and entopeduncular nucleus (EP), and decreasing it in the LH of the lesioned side. These changes were also significant when compared to the corresponding values of the other experimental groups. Again, in LY-SKF group no modification of the lesion- induced metabolic asymmetry in the GP was found. These results indicate that priming exerts a facilitatory influence on the ability of D-1 receptors to stimulate the striato-nigral and striato-entopeduncular pathway, suggesting that changes in the effectiveness of dopamine in activating its postsynaptic target elements might contribute to the mechanism of sensitization to drugs stimulating dopaminergic transmission.
| Original language | English |
|---|---|
| Pages (from-to) | 264-269 |
| Number of pages | 6 |
| Journal | Synapse |
| Volume | 13 |
| Issue number | 3 |
| Publication status | Published - 1993 |
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ASJC Scopus subject areas
- Physiology
- Neuroscience(all)
- Pharmacology
Cite this
Local cerebral glucose utilization after D1 receptor stimulation in 6- OHDA lesioned rats : Effect of sensitization (priming) with a dopaminergic agonist. / Morelli, M.; Pontieri, F. E.; Linfante, I.; Orzi, F.; Di Chiara, G.
In: Synapse, Vol. 13, No. 3, 1993, p. 264-269.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Local cerebral glucose utilization after D1 receptor stimulation in 6- OHDA lesioned rats
T2 - Effect of sensitization (priming) with a dopaminergic agonist
AU - Morelli, M.
AU - Pontieri, F. E.
AU - Linfante, I.
AU - Orzi, F.
AU - Di Chiara, G.
PY - 1993
Y1 - 1993
N2 - In rats bearing unilateral 6-hydroxydopamine (6-OHDA) lesions of the dopaminergic nigro-striatal neurons, a single administration of a D-2 agonist (LY 17155) potentiates the contralateral turning induced by a D-1 agonist (SKF 38393). To identify the neural substrate of this form of sensitization (priming), we studied the local cerebral glucose utilization (lCMR(glc)) in 6-OHDA lesioned animals treated, 3 days apart, as follows: (1) saline- saline, (2) LY 171555-saline, (3) saline-SKF 38393 and (4) LY 171555-SKF 38393. The unilateral 6-OHDA lesion per se (Sal-Sal) produced increases in lCMR(glc) in the globus pallidus (GP) and in the lateral habenula (LH) of the lesioned hemisphere. lCMR(glc) in LY-Sal group were similar to those measured in the Sal-Sal group. Administration of SKF 38393 to drug-naive rats (Sal- SKF) abolished the lesion-induced metabolic asymmetry in the LH but did not have any effect on the GP; furthermore, it increased lCMR(glc) in the substantia nigra pars reticulata (SNr) of the lesioned side. After priming with LY 171555, administration of SKF 38393 (LY-SKF) produced marked metabolic asymmetries by increasing lCMR(glc) in the SNr and entopeduncular nucleus (EP), and decreasing it in the LH of the lesioned side. These changes were also significant when compared to the corresponding values of the other experimental groups. Again, in LY-SKF group no modification of the lesion- induced metabolic asymmetry in the GP was found. These results indicate that priming exerts a facilitatory influence on the ability of D-1 receptors to stimulate the striato-nigral and striato-entopeduncular pathway, suggesting that changes in the effectiveness of dopamine in activating its postsynaptic target elements might contribute to the mechanism of sensitization to drugs stimulating dopaminergic transmission.
AB - In rats bearing unilateral 6-hydroxydopamine (6-OHDA) lesions of the dopaminergic nigro-striatal neurons, a single administration of a D-2 agonist (LY 17155) potentiates the contralateral turning induced by a D-1 agonist (SKF 38393). To identify the neural substrate of this form of sensitization (priming), we studied the local cerebral glucose utilization (lCMR(glc)) in 6-OHDA lesioned animals treated, 3 days apart, as follows: (1) saline- saline, (2) LY 171555-saline, (3) saline-SKF 38393 and (4) LY 171555-SKF 38393. The unilateral 6-OHDA lesion per se (Sal-Sal) produced increases in lCMR(glc) in the globus pallidus (GP) and in the lateral habenula (LH) of the lesioned hemisphere. lCMR(glc) in LY-Sal group were similar to those measured in the Sal-Sal group. Administration of SKF 38393 to drug-naive rats (Sal- SKF) abolished the lesion-induced metabolic asymmetry in the LH but did not have any effect on the GP; furthermore, it increased lCMR(glc) in the substantia nigra pars reticulata (SNr) of the lesioned side. After priming with LY 171555, administration of SKF 38393 (LY-SKF) produced marked metabolic asymmetries by increasing lCMR(glc) in the SNr and entopeduncular nucleus (EP), and decreasing it in the LH of the lesioned side. These changes were also significant when compared to the corresponding values of the other experimental groups. Again, in LY-SKF group no modification of the lesion- induced metabolic asymmetry in the GP was found. These results indicate that priming exerts a facilitatory influence on the ability of D-1 receptors to stimulate the striato-nigral and striato-entopeduncular pathway, suggesting that changes in the effectiveness of dopamine in activating its postsynaptic target elements might contribute to the mechanism of sensitization to drugs stimulating dopaminergic transmission.
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M3 - Article
C2 - 8098880
AN - SCOPUS:0027405522
VL - 13
SP - 264
EP - 269
JO - Synapse
JF - Synapse
SN - 0887-4476
IS - 3
ER -