Local control and distant metastasis after electrochemotherapy of a canine anal melanoma

Enrico P. Spugnini, Marino Filipponi, Luca Romani, Ivan Dotsinsky, Nikolay Mudrov, Adone Baroni, Eleonora Ruocco, Maria Teresa Laieta, Vincenzo Montesarchio, Roberto Cassandro, Gennaro Citro, Alfonso Baldi

Research output: Contribution to journalArticle

Abstract

Canine anal melanoma is an aggressive neoplasm that rapidly leads to constipation in dogs, thus mimicking the behavior of their human counterpart. In this paper, the successful local palliation of this neoplasm is described using cisplatin selectively driven within the tumor cells by trains of biphasic pulses. The dog experienced tumor reduction with restoration of normal defecation for three months, then experienced massive dissemination to the sublumbar lymph nodes that led to intestinal obstruction and euthanasia. Electrochemotherapy (ECT) is a safe palliative therapy for such neoplasm and warrants further investigations in dogs as well humans.

Original languageEnglish
Pages (from-to)897-900
Number of pages4
JournalIn Vivo
Volume21
Issue number5
Publication statusPublished - Sep 2007

Keywords

  • Anal melanoma
  • Biphasic pulses
  • Cisplatin
  • Dog
  • Immunohistochemistry

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Local control and distant metastasis after electrochemotherapy of a canine anal melanoma'. Together they form a unique fingerprint.

  • Cite this

    Spugnini, E. P., Filipponi, M., Romani, L., Dotsinsky, I., Mudrov, N., Baroni, A., Ruocco, E., Laieta, M. T., Montesarchio, V., Cassandro, R., Citro, G., & Baldi, A. (2007). Local control and distant metastasis after electrochemotherapy of a canine anal melanoma. In Vivo, 21(5), 897-900.