Local control and survival in early breast cancer: The milan trial

Umberto Veronesi, Roberto Zucali, Alberto Luini

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From 1973 to 1980, 701 patients with breast cancer measuring less than 2 cm in pathological diameter and with no palpable axillary lymph nodes were randomized to Halsted mastectomy (349) or to "quadrantectomy" with axillary dissection and radiotherapy to the ipsilateral breast time (QUART) (352). The two groups were comparable in age distribution, size and site of primary tumor, menopausal status; and frequency of axillary metastases. At 8 years, the disease-free survival was 77% for the Halsted patients and 80% for the "quadrantectomy" patients, while overall survival was 83% and 85%, respectively. Disease-free and overall survival curves show no difference between the two groups. Breast cancer of small size (less than 2 cm) may be safely treated with conservative treatment. Mutilating operations are not justified.

Original languageEnglish
Pages (from-to)717-720
Number of pages4
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number5
Publication statusPublished - 1986


  • Conservative surgery
  • Early breast cancer
  • Radiotherapy of breast cancer

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation


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