Local excision after preoperative chemoradiotherapy for rectal cancer: Results of a multicenter phase II clinical trial

Salvatore Pucciarelli, Antonino De Paoli, Mario Guerrieri, Giuseppe La Torre, Isacco Maretto, Francesco De Marchi, Giovanna Mantello, Maria Antonietta Gambacorta, Vincenzo Canzonieri, Donato Nitti, Vincenzo Valentini, Claudio Coco

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Transanal local excision has been suggested as an attractive approach for patients with rectal cancer who show a major clinical response after preoperative chemoradiotherapy. OBJECTIVE: To evaluate the impact of transanal local excision on the local recurrence of rectal cancer in patients who had a major clinical response after preoperative chemoradiotherapy. DESIGN: Sequential 2-stage phase II study for early efficacy. SETTING: Multicenter study. PATIENTS: Patients with clinical T3 or low-lying T2 rectal adenocarcinoma that showed a major clinical response after a preoperative chemoradiotherapy. Eligible patients underwent a full-thickness transanal local excision. According to their histopathology, the patients staged as ypT0-1 were observed, while the remaining patients were recommended to undergo a subsequent total mesorectal excision. MAIN OUTCOME MEASURES: A local recurrence rate of

Original languageEnglish
Pages (from-to)1349-1356
Number of pages8
JournalDiseases of the Colon and Rectum
Volume56
Issue number12
DOIs
Publication statusPublished - Dec 2013

Keywords

  • Chemoradiotherapy
  • Local control
  • Local excision
  • Rectal cancer

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Local excision after preoperative chemoradiotherapy for rectal cancer: Results of a multicenter phase II clinical trial'. Together they form a unique fingerprint.

Cite this