Local excision after preoperative chemoradiotherapy for rectal cancer: Results of a multicenter phase II clinical trial

Salvatore Pucciarelli; Antonino De Paoli; Mario Guerrieri; Giuseppe La Torre; Isacco Maretto; Francesco De Marchi; Giovanna Mantello; Maria Antonietta Gambacorta; Vincenzo Canzonieri; Donato Nitti; Vincenzo Valentini; Claudio Coco

doi:10.1097/DCR.0b013e3182a2303e

Local excision after preoperative chemoradiotherapy for rectal cancer: Results of a multicenter phase II clinical trial

Salvatore Pucciarelli, Antonino De Paoli, Mario Guerrieri, Giuseppe La Torre, Isacco Maretto, Francesco De Marchi, Giovanna Mantello, Maria Antonietta Gambacorta, Vincenzo Canzonieri, Donato Nitti, Vincenzo Valentini, Claudio Coco

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Transanal local excision has been suggested as an attractive approach for patients with rectal cancer who show a major clinical response after preoperative chemoradiotherapy. OBJECTIVE: To evaluate the impact of transanal local excision on the local recurrence of rectal cancer in patients who had a major clinical response after preoperative chemoradiotherapy. DESIGN: Sequential 2-stage phase II study for early efficacy. SETTING: Multicenter study. PATIENTS: Patients with clinical T3 or low-lying T2 rectal adenocarcinoma that showed a major clinical response after a preoperative chemoradiotherapy. Eligible patients underwent a full-thickness transanal local excision. According to their histopathology, the patients staged as ypT0-1 were observed, while the remaining patients were recommended to undergo a subsequent total mesorectal excision. MAIN OUTCOME MEASURES: A local recurrence rate of

Original language	English
Pages (from-to)	1349-1356
Number of pages	8
Journal	Diseases of the Colon and Rectum
Volume	56
Issue number	12
DOIs	https://doi.org/10.1097/DCR.0b013e3182a2303e
Publication status	Published - Dec 2013

Keywords

Chemoradiotherapy
Local control
Local excision
Rectal cancer

ASJC Scopus subject areas

Gastroenterology

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10.1097/DCR.0b013e3182a2303e

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Pucciarelli, S., De Paoli, A., Guerrieri, M., La Torre, G., Maretto, I., De Marchi, F., Mantello, G., Gambacorta, M. A., Canzonieri, V., Nitti, D., Valentini, V., & Coco, C. (2013). Local excision after preoperative chemoradiotherapy for rectal cancer: Results of a multicenter phase II clinical trial. Diseases of the Colon and Rectum, 56(12), 1349-1356. https://doi.org/10.1097/DCR.0b013e3182a2303e

Local excision after preoperative chemoradiotherapy for rectal cancer : Results of a multicenter phase II clinical trial. / Pucciarelli, Salvatore; De Paoli, Antonino; Guerrieri, Mario; La Torre, Giuseppe; Maretto, Isacco; De Marchi, Francesco; Mantello, Giovanna; Gambacorta, Maria Antonietta; Canzonieri, Vincenzo; Nitti, Donato; Valentini, Vincenzo; Coco, Claudio.

In: Diseases of the Colon and Rectum, Vol. 56, No. 12, 12.2013, p. 1349-1356.

Research output: Contribution to journal › Article › peer-review

Pucciarelli, S, De Paoli, A, Guerrieri, M, La Torre, G, Maretto, I, De Marchi, F, Mantello, G, Gambacorta, MA, Canzonieri, V, Nitti, D, Valentini, V & Coco, C 2013, 'Local excision after preoperative chemoradiotherapy for rectal cancer: Results of a multicenter phase II clinical trial', Diseases of the Colon and Rectum, vol. 56, no. 12, pp. 1349-1356. https://doi.org/10.1097/DCR.0b013e3182a2303e

Pucciarelli, Salvatore ; De Paoli, Antonino ; Guerrieri, Mario ; La Torre, Giuseppe ; Maretto, Isacco ; De Marchi, Francesco ; Mantello, Giovanna ; Gambacorta, Maria Antonietta ; Canzonieri, Vincenzo ; Nitti, Donato ; Valentini, Vincenzo ; Coco, Claudio. / Local excision after preoperative chemoradiotherapy for rectal cancer : Results of a multicenter phase II clinical trial. In: Diseases of the Colon and Rectum. 2013 ; Vol. 56, No. 12. pp. 1349-1356.

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AU - Maretto, Isacco

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AU - Mantello, Giovanna

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