TY - JOUR
T1 - Local excision after preoperative chemoradiotherapy for rectal cancer
T2 - Results of a multicenter phase II clinical trial
AU - Pucciarelli, Salvatore
AU - De Paoli, Antonino
AU - Guerrieri, Mario
AU - La Torre, Giuseppe
AU - Maretto, Isacco
AU - De Marchi, Francesco
AU - Mantello, Giovanna
AU - Gambacorta, Maria Antonietta
AU - Canzonieri, Vincenzo
AU - Nitti, Donato
AU - Valentini, Vincenzo
AU - Coco, Claudio
PY - 2013/12
Y1 - 2013/12
N2 - BACKGROUND: Transanal local excision has been suggested as an attractive approach for patients with rectal cancer who show a major clinical response after preoperative chemoradiotherapy. OBJECTIVE: To evaluate the impact of transanal local excision on the local recurrence of rectal cancer in patients who had a major clinical response after preoperative chemoradiotherapy. DESIGN: Sequential 2-stage phase II study for early efficacy. SETTING: Multicenter study. PATIENTS: Patients with clinical T3 or low-lying T2 rectal adenocarcinoma that showed a major clinical response after a preoperative chemoradiotherapy. Eligible patients underwent a full-thickness transanal local excision. According to their histopathology, the patients staged as ypT0-1 were observed, while the remaining patients were recommended to undergo a subsequent total mesorectal excision. MAIN OUTCOME MEASURES: A local recurrence rate of
AB - BACKGROUND: Transanal local excision has been suggested as an attractive approach for patients with rectal cancer who show a major clinical response after preoperative chemoradiotherapy. OBJECTIVE: To evaluate the impact of transanal local excision on the local recurrence of rectal cancer in patients who had a major clinical response after preoperative chemoradiotherapy. DESIGN: Sequential 2-stage phase II study for early efficacy. SETTING: Multicenter study. PATIENTS: Patients with clinical T3 or low-lying T2 rectal adenocarcinoma that showed a major clinical response after a preoperative chemoradiotherapy. Eligible patients underwent a full-thickness transanal local excision. According to their histopathology, the patients staged as ypT0-1 were observed, while the remaining patients were recommended to undergo a subsequent total mesorectal excision. MAIN OUTCOME MEASURES: A local recurrence rate of
KW - Chemoradiotherapy
KW - Local control
KW - Local excision
KW - Rectal cancer
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U2 - 10.1097/DCR.0b013e3182a2303e
DO - 10.1097/DCR.0b013e3182a2303e
M3 - Article
C2 - 24201388
AN - SCOPUS:84888354365
VL - 56
SP - 1349
EP - 1356
JO - Diseases of the Colon and Rectum
JF - Diseases of the Colon and Rectum
SN - 0012-3706
IS - 12
ER -