Local microwave-hyperthermia and intravesical chemotherapy with mitomycin C as neoadjuvant treatment for selected multifocal and unresectable superficial bladder tumors

R. Colombo, L. F. Da Pozzo, A. Lev, M. Grasso, F. Francesca, F. Montorsi, V. Di Girolamo, P. Rigatti

Research output: Contribution to journalArticle

Abstract

Fourteen patients suffering from multifocal recurrent superficial bladder tumors (considered technically unresectable by means of TUR) having refused radical cystectomy as a first option then underwent a combined regimen of local microwave-induced hyperthermia plus topical chemotherapy administered as an ablating or debulking neoadjuvant approach. Endovesical hyperthermia was delivered using a prototype system (SBTS-101®) based on a microwave applicator which irradiates the bladder walls by means of a circulating solution of mitomycin C. All patients were subjected to eight bi-weekly or weekly sessions carried out on an outpatient basis. The treatment was relatively easy from a technical point of view and generally well-tolerated. After treatment completion, all patients underwent TUR for residual tumors or suspect areas. Complete or partial tumor eradication was histologically attested in 7 and 7 patients respectively. Out of those who showed partial response 3 underwent radical cystectomy after TUR while the bladders of remaining patients were saved. In a median 11 month follow up, 6 superficial transitional recurrences were documented and easily eradicated by TUR or laser therapy.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalActa Urologica Italica
Volume9
Issue number4
Publication statusPublished - 1995

Keywords

  • bladder
  • intravesical chemotherapy
  • local hyperthermia
  • transitional cell carcinoma

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Local microwave-hyperthermia and intravesical chemotherapy with mitomycin C as neoadjuvant treatment for selected multifocal and unresectable superficial bladder tumors'. Together they form a unique fingerprint.

  • Cite this