Fourteen patients suffering from multifocal recurrent superficial bladder tumors (considered technically unresectable by means of TUR) having refused radical cystectomy as a first option then underwent a combined regimen of local microwave-induced hyperthermia plus topical chemotherapy administered as an ablating or debulking neoadjuvant approach. Endovesical hyperthermia was delivered using a prototype system (SBTS-101®) based on a microwave applicator which irradiates the bladder walls by means of a circulating solution of mitomycin C. All patients were subjected to eight bi-weekly or weekly sessions carried out on an outpatient basis. The treatment was relatively easy from a technical point of view and generally well-tolerated. After treatment completion, all patients underwent TUR for residual tumors or suspect areas. Complete or partial tumor eradication was histologically attested in 7 and 7 patients respectively. Out of those who showed partial response 3 underwent radical cystectomy after TUR while the bladders of remaining patients were saved. In a median 11 month follow up, 6 superficial transitional recurrences were documented and easily eradicated by TUR or laser therapy.
|Number of pages||5|
|Journal||Acta Urologica Italica|
|Publication status||Published - 1995|
- intravesical chemotherapy
- local hyperthermia
- transitional cell carcinoma
ASJC Scopus subject areas