Local recurrence after curative resection for colorectal cancer: frequency, risk factors and treatment.

S. Stipa, V. Nicolanti, C. Botti, M. Cosimelli, E. Mannella, F. Stipa, D. Giannarelli, C. Bangrazi, R. Cavaliere

Research output: Contribution to journalArticlepeer-review


Analysis of 498 patients with colorectal carcinoma was retrospectively reviewed to evaluate the incidence, risk factors and therapy of local recurrent carcinoma following curative resection. Complete follow-up information was obtained in all but four patients (99.2%). After a median follow up of 42 months, 64 out of 469 (13.6%) patients developed local recurrence (LR). The incidence of LR was higher in rectal than in colon cancer patients (18.3% vs 8.9%) (P less than 0.005). Separate univariate and Cox analyses for rectal patients showed tumor site (P less than 0.02). Dukes stage (P less than 0.002), and adjuvant radiotherapy (P = 0.05) determined risk of LR. For colon cancer patients risk of LR was determined by histological tumor grade (P less than 0.01). Out of 64 patients, 5 (7.8%) underwent radical excision of LR. Forty percent of these survived at 5-year (P less than 0.08). Palliative treatment (radio-chemotherapy) obtained a 5-year survival of 15.3%, with no survivors in no-treatment group. These results suggest that local recurrent colorectal carcinoma remain a difficult treatment problem. More effective combinations of surgery and adjuvant therapy are therefore mandatory to reduce the incidence of local failure in high risk colorectal patients.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalJournal of surgical oncology. Supplement
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Medicine(all)


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