Local recurrence of soft tissue sarcoma: a radiomic analysis

Alberto Stefano Tagliafico, Bianca Bignotti, Federica Rossi, Francesca Valdora, Carlo Martinoli

Research output: Contribution to journalArticle

Abstract

Background To perform a radiomics analysis in local recurrence (LR) surveillance of limb soft tissue sarcoma (STS) Patients and methods This is a sub-study of a prospective multicenter study with Institutional Review Board approval supported by ESSR (European Society of Musculoskeletal Radiology). radiomics analysis was done on fast spin echo axial T1w, T2w fat saturated and post-contrast T1w (T1wGd) 1.5T MRI images of consecutively recruited patients between March 2016 and September 2018. Results N = 11 adult patients (6 men and 5 women; mean age 57.8 ± 17.8) underwent MRI to exclude STS LR: a total of 33 follow-up events were evaluated. A total of 198 data-sets per patients of both pathological and normal tissue were analyzed. Four radiomics features were significantly correlated to tumor size (p < 0.02) and four radiomics features were correlated with grading (p < 0.05). ROC analysis showed an AUC between 0.71 (95%CI: 0.55-0.87) for T1w and 0.96 (95%CI: 0.87-1.00) for post-contrast T1w. Conclusions radiomics features allow to differentiate normal tissue from pathological tissue in MRI surveillance of local recurrence of STS. radiomics in STS evaluation is useful not only for detection purposes but also for lesion characterization.

Original languageEnglish
Pages (from-to)300-306
Number of pages7
JournalRadiology and Oncology
Volume53
Issue number3
DOIs
Publication statusPublished - Sep 24 2019

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Sarcoma
Recurrence
Research Ethics Committees
ROC Curve
Multicenter Studies
Area Under Curve
Extremities
Fats
Prospective Studies
Neoplasms

Keywords

  • magnetic resonance imaging
  • recurrence
  • ROC curve
  • sarcoma

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Local recurrence of soft tissue sarcoma : a radiomic analysis. / Tagliafico, Alberto Stefano; Bignotti, Bianca; Rossi, Federica; Valdora, Francesca; Martinoli, Carlo.

In: Radiology and Oncology, Vol. 53, No. 3, 24.09.2019, p. 300-306.

Research output: Contribution to journalArticle

Tagliafico, Alberto Stefano ; Bignotti, Bianca ; Rossi, Federica ; Valdora, Francesca ; Martinoli, Carlo. / Local recurrence of soft tissue sarcoma : a radiomic analysis. In: Radiology and Oncology. 2019 ; Vol. 53, No. 3. pp. 300-306.
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