Abstract
Background. Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the breast (local relapse) or development of a contralateral tumor. Methods. Seven hundred fifty-seven patients with unilateral invasive breast cancer (T0-2. N0-1, M0) were treated conservatively (wide local excision and radiotherapy) at the Institut Gustave-Roussy between 1970 and 1982. The median follow-up was 9 years. The risk of local relapse or development of a contralateral tumor (as first event) was studied by univariate analysis for the main clinical, pathologic, and treatment factors. Those found to be significant were entered into a Cox proportional regression analysis. Results. Fifty-one patients relapsed in the treated breast (actuarial local relapse rates at 5 and 10 years were 5% and 8%, respectively) and 34 in the contralateral breast (actuarial contralateral tumor rates at 5 and 10 years were 3% and 6%, respectively). Multivariate analysis of the risk factors for local relapse showed that only age younger than 40 years (P <0.02) or inadequate surgical excision (P <0.02) were significant. No particular risk factors for contralateral tumor development were identified. Conclusions. Overall, for most patients, the risk of local relapse or of developing a contralateral tumor was low. A small number of young patients with inadequately excised tumors are at higher risk of local relapse, need more meticulous surgery, and may merit higher dose radiotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 2260-2265 |
| Number of pages | 6 |
| Journal | Cancer |
| Volume | 76 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1995 |
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Keywords
- breast cancer
- conservation
- contralateral tumors
- local control
- multivariate analysis
- prognostic factors
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Local relapse and contralateral tumor rates in patients with breast cancer treated with conservative surgery and radiotherapy (Institut Gustave Roussy 1970-1982). / Dewar, J. A.; Arriagada, R.; Benhamou, S.; Benhamou, E.; Bretel, J. J.; Pellae- Cosset, B.; Marin, J. L.; Petit, J. Y.; Cantesso, G.; Sarrazin, D.
In: Cancer, Vol. 76, No. 11, 1995, p. 2260-2265.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Local relapse and contralateral tumor rates in patients with breast cancer treated with conservative surgery and radiotherapy (Institut Gustave Roussy 1970-1982)
AU - Dewar, J. A.
AU - Arriagada, R.
AU - Benhamou, S.
AU - Benhamou, E.
AU - Bretel, J. J.
AU - Pellae- Cosset, B.
AU - Marin, J. L.
AU - Petit, J. Y.
AU - Cantesso, G.
AU - Sarrazin, D.
PY - 1995
Y1 - 1995
N2 - Background. Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the breast (local relapse) or development of a contralateral tumor. Methods. Seven hundred fifty-seven patients with unilateral invasive breast cancer (T0-2. N0-1, M0) were treated conservatively (wide local excision and radiotherapy) at the Institut Gustave-Roussy between 1970 and 1982. The median follow-up was 9 years. The risk of local relapse or development of a contralateral tumor (as first event) was studied by univariate analysis for the main clinical, pathologic, and treatment factors. Those found to be significant were entered into a Cox proportional regression analysis. Results. Fifty-one patients relapsed in the treated breast (actuarial local relapse rates at 5 and 10 years were 5% and 8%, respectively) and 34 in the contralateral breast (actuarial contralateral tumor rates at 5 and 10 years were 3% and 6%, respectively). Multivariate analysis of the risk factors for local relapse showed that only age younger than 40 years (P <0.02) or inadequate surgical excision (P <0.02) were significant. No particular risk factors for contralateral tumor development were identified. Conclusions. Overall, for most patients, the risk of local relapse or of developing a contralateral tumor was low. A small number of young patients with inadequately excised tumors are at higher risk of local relapse, need more meticulous surgery, and may merit higher dose radiotherapy.
AB - Background. Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the breast (local relapse) or development of a contralateral tumor. Methods. Seven hundred fifty-seven patients with unilateral invasive breast cancer (T0-2. N0-1, M0) were treated conservatively (wide local excision and radiotherapy) at the Institut Gustave-Roussy between 1970 and 1982. The median follow-up was 9 years. The risk of local relapse or development of a contralateral tumor (as first event) was studied by univariate analysis for the main clinical, pathologic, and treatment factors. Those found to be significant were entered into a Cox proportional regression analysis. Results. Fifty-one patients relapsed in the treated breast (actuarial local relapse rates at 5 and 10 years were 5% and 8%, respectively) and 34 in the contralateral breast (actuarial contralateral tumor rates at 5 and 10 years were 3% and 6%, respectively). Multivariate analysis of the risk factors for local relapse showed that only age younger than 40 years (P <0.02) or inadequate surgical excision (P <0.02) were significant. No particular risk factors for contralateral tumor development were identified. Conclusions. Overall, for most patients, the risk of local relapse or of developing a contralateral tumor was low. A small number of young patients with inadequately excised tumors are at higher risk of local relapse, need more meticulous surgery, and may merit higher dose radiotherapy.
KW - breast cancer
KW - conservation
KW - contralateral tumors
KW - local control
KW - multivariate analysis
KW - prognostic factors
UR - http://www.scopus.com/inward/record.url?scp=0028861076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028861076&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(19951201)76:11<2260::AID-CNCR2820761113>3.0.CO;2-D
DO - 10.1002/1097-0142(19951201)76:11<2260::AID-CNCR2820761113>3.0.CO;2-D
M3 - Article
C2 - 8635030
AN - SCOPUS:0028861076
VL - 76
SP - 2260
EP - 2265
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 11
ER -