Local relapse and contralateral tumor rates in patients with breast cancer treated with conservative surgery and radiotherapy (Institut Gustave Roussy 1970-1982)

J. A. Dewar, R. Arriagada, S. Benhamou, E. Benhamou, J. J. Bretel, B. Pellae- Cosset, J. L. Marin, J. Y. Petit, G. Cantesso, D. Sarrazin

Research output: Contribution to journalArticle

Abstract

Background. Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the breast (local relapse) or development of a contralateral tumor. Methods. Seven hundred fifty-seven patients with unilateral invasive breast cancer (T0-2. N0-1, M0) were treated conservatively (wide local excision and radiotherapy) at the Institut Gustave-Roussy between 1970 and 1982. The median follow-up was 9 years. The risk of local relapse or development of a contralateral tumor (as first event) was studied by univariate analysis for the main clinical, pathologic, and treatment factors. Those found to be significant were entered into a Cox proportional regression analysis. Results. Fifty-one patients relapsed in the treated breast (actuarial local relapse rates at 5 and 10 years were 5% and 8%, respectively) and 34 in the contralateral breast (actuarial contralateral tumor rates at 5 and 10 years were 3% and 6%, respectively). Multivariate analysis of the risk factors for local relapse showed that only age younger than 40 years (P <0.02) or inadequate surgical excision (P <0.02) were significant. No particular risk factors for contralateral tumor development were identified. Conclusions. Overall, for most patients, the risk of local relapse or of developing a contralateral tumor was low. A small number of young patients with inadequately excised tumors are at higher risk of local relapse, need more meticulous surgery, and may merit higher dose radiotherapy.

Original languageEnglish
Pages (from-to)2260-2265
Number of pages6
JournalCancer
Volume76
Issue number11
DOIs
Publication statusPublished - 1995

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Radiotherapy
Breast Neoplasms
Recurrence
Breast
Neoplasms
Multivariate Analysis
Regression Analysis
Therapeutics

Keywords

  • breast cancer
  • conservation
  • contralateral tumors
  • local control
  • multivariate analysis
  • prognostic factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Local relapse and contralateral tumor rates in patients with breast cancer treated with conservative surgery and radiotherapy (Institut Gustave Roussy 1970-1982). / Dewar, J. A.; Arriagada, R.; Benhamou, S.; Benhamou, E.; Bretel, J. J.; Pellae- Cosset, B.; Marin, J. L.; Petit, J. Y.; Cantesso, G.; Sarrazin, D.

In: Cancer, Vol. 76, No. 11, 1995, p. 2260-2265.

Research output: Contribution to journalArticle

Dewar, J. A. ; Arriagada, R. ; Benhamou, S. ; Benhamou, E. ; Bretel, J. J. ; Pellae- Cosset, B. ; Marin, J. L. ; Petit, J. Y. ; Cantesso, G. ; Sarrazin, D. / Local relapse and contralateral tumor rates in patients with breast cancer treated with conservative surgery and radiotherapy (Institut Gustave Roussy 1970-1982). In: Cancer. 1995 ; Vol. 76, No. 11. pp. 2260-2265.
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abstract = "Background. Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the breast (local relapse) or development of a contralateral tumor. Methods. Seven hundred fifty-seven patients with unilateral invasive breast cancer (T0-2. N0-1, M0) were treated conservatively (wide local excision and radiotherapy) at the Institut Gustave-Roussy between 1970 and 1982. The median follow-up was 9 years. The risk of local relapse or development of a contralateral tumor (as first event) was studied by univariate analysis for the main clinical, pathologic, and treatment factors. Those found to be significant were entered into a Cox proportional regression analysis. Results. Fifty-one patients relapsed in the treated breast (actuarial local relapse rates at 5 and 10 years were 5{\%} and 8{\%}, respectively) and 34 in the contralateral breast (actuarial contralateral tumor rates at 5 and 10 years were 3{\%} and 6{\%}, respectively). Multivariate analysis of the risk factors for local relapse showed that only age younger than 40 years (P <0.02) or inadequate surgical excision (P <0.02) were significant. No particular risk factors for contralateral tumor development were identified. Conclusions. Overall, for most patients, the risk of local relapse or of developing a contralateral tumor was low. A small number of young patients with inadequately excised tumors are at higher risk of local relapse, need more meticulous surgery, and may merit higher dose radiotherapy.",
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T1 - Local relapse and contralateral tumor rates in patients with breast cancer treated with conservative surgery and radiotherapy (Institut Gustave Roussy 1970-1982)

AU - Dewar, J. A.

AU - Arriagada, R.

AU - Benhamou, S.

AU - Benhamou, E.

AU - Bretel, J. J.

AU - Pellae- Cosset, B.

AU - Marin, J. L.

AU - Petit, J. Y.

AU - Cantesso, G.

AU - Sarrazin, D.

PY - 1995

Y1 - 1995

N2 - Background. Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the breast (local relapse) or development of a contralateral tumor. Methods. Seven hundred fifty-seven patients with unilateral invasive breast cancer (T0-2. N0-1, M0) were treated conservatively (wide local excision and radiotherapy) at the Institut Gustave-Roussy between 1970 and 1982. The median follow-up was 9 years. The risk of local relapse or development of a contralateral tumor (as first event) was studied by univariate analysis for the main clinical, pathologic, and treatment factors. Those found to be significant were entered into a Cox proportional regression analysis. Results. Fifty-one patients relapsed in the treated breast (actuarial local relapse rates at 5 and 10 years were 5% and 8%, respectively) and 34 in the contralateral breast (actuarial contralateral tumor rates at 5 and 10 years were 3% and 6%, respectively). Multivariate analysis of the risk factors for local relapse showed that only age younger than 40 years (P <0.02) or inadequate surgical excision (P <0.02) were significant. No particular risk factors for contralateral tumor development were identified. Conclusions. Overall, for most patients, the risk of local relapse or of developing a contralateral tumor was low. A small number of young patients with inadequately excised tumors are at higher risk of local relapse, need more meticulous surgery, and may merit higher dose radiotherapy.

AB - Background. Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the breast (local relapse) or development of a contralateral tumor. Methods. Seven hundred fifty-seven patients with unilateral invasive breast cancer (T0-2. N0-1, M0) were treated conservatively (wide local excision and radiotherapy) at the Institut Gustave-Roussy between 1970 and 1982. The median follow-up was 9 years. The risk of local relapse or development of a contralateral tumor (as first event) was studied by univariate analysis for the main clinical, pathologic, and treatment factors. Those found to be significant were entered into a Cox proportional regression analysis. Results. Fifty-one patients relapsed in the treated breast (actuarial local relapse rates at 5 and 10 years were 5% and 8%, respectively) and 34 in the contralateral breast (actuarial contralateral tumor rates at 5 and 10 years were 3% and 6%, respectively). Multivariate analysis of the risk factors for local relapse showed that only age younger than 40 years (P <0.02) or inadequate surgical excision (P <0.02) were significant. No particular risk factors for contralateral tumor development were identified. Conclusions. Overall, for most patients, the risk of local relapse or of developing a contralateral tumor was low. A small number of young patients with inadequately excised tumors are at higher risk of local relapse, need more meticulous surgery, and may merit higher dose radiotherapy.

KW - breast cancer

KW - conservation

KW - contralateral tumors

KW - local control

KW - multivariate analysis

KW - prognostic factors

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