Local Stability of the Trunk in Patients with Degenerative Cerebellar Ataxia During Walking

Giorgia Chini, Alberto Ranavolo, Francesco Draicchio, Carlo Casali, Conte Carmela, Giovanni Martino, Luca Leonardi, Luca Padua, Gianluca Coppola, Francesco Pierelli, Mariano Serrao

Research output: Contribution to journalArticle

Abstract

This study aims to evaluate trunk local stability in a group of patients with degenerative primary cerebellar ataxia and to correlate it with spatio-temporal parameters, clinical variables, and history of falls. Sixteen patients affected by degenerative cerebellar ataxia and 16 gender- and age-matched healthy adults were studied by means of an inertial sensor to measure trunk kinematics and spatio-temporal parameters during over-ground walking. Trunk local dynamic stability was quantified by the maximum Lyapunov exponent with short data series of the acceleration data. According to this index, low values indicate more stable trunk dynamics, while high values denote less stable trunk dynamics. Disease severity was assessed by means of International Cooperative Ataxia Rating Scale (ICARS) according to which higher values correspond to more severe disease, while lower values correspond to less severe disease. Patients displayed a higher short-term maximum Lyapunov exponent than controls in all three spatial planes, which was correlated with the age, onset of the disease, and history of falls. Furthermore, the maximum Lyapunov exponent was negatively correlated with ICARS balance, ICARS posture, and ICARS total scores. These findings indicate that trunk local stability during gait is lower in patients with cerebellar degenerative ataxia than that in healthy controls and that this may increase the risk of falls. Local dynamic stability of the trunk seems to be an important aspect in patients with ataxia and could be a useful tool in the evaluation of rehabilitative and pharmacological treatment outcomes.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalCerebellum
DOIs
Publication statusAccepted/In press - Jan 25 2016

Fingerprint

Cerebellar Ataxia
Ataxia
Walking
Posture
Gait
Age of Onset
Biomechanical Phenomena
Pharmacology

Keywords

  • Cerebellar ataxia
  • Gait
  • Local dynamic stability
  • Trunk stability

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Chini, G., Ranavolo, A., Draicchio, F., Casali, C., Carmela, C., Martino, G., ... Serrao, M. (Accepted/In press). Local Stability of the Trunk in Patients with Degenerative Cerebellar Ataxia During Walking. Cerebellum, 1-8. https://doi.org/10.1007/s12311-016-0760-6

Local Stability of the Trunk in Patients with Degenerative Cerebellar Ataxia During Walking. / Chini, Giorgia; Ranavolo, Alberto; Draicchio, Francesco; Casali, Carlo; Carmela, Conte; Martino, Giovanni; Leonardi, Luca; Padua, Luca; Coppola, Gianluca; Pierelli, Francesco; Serrao, Mariano.

In: Cerebellum, 25.01.2016, p. 1-8.

Research output: Contribution to journalArticle

Chini, Giorgia ; Ranavolo, Alberto ; Draicchio, Francesco ; Casali, Carlo ; Carmela, Conte ; Martino, Giovanni ; Leonardi, Luca ; Padua, Luca ; Coppola, Gianluca ; Pierelli, Francesco ; Serrao, Mariano. / Local Stability of the Trunk in Patients with Degenerative Cerebellar Ataxia During Walking. In: Cerebellum. 2016 ; pp. 1-8.
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