Local therapy for breast cancer in malignant lymphoma survivors

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6 Citations (Scopus)

Abstract

Summary: Aims: Breast cancer is the most frequent secondary tumor in young women previously treated with mantle radiation for Hodgkin's disease. Prior therapeutic radiation to the breast region is considered an absolute contraindication to breast conservative surgery, and mastectomy is considered the treatment of choice. We performed a retrospective review to assess the potential of performing breast conservative surgery and intraoperative radiotherapy with electrons (ELIOT), in these patients. Methods and results: Forty-three patients affected by early breast cancer, previously treated with mantle radiation for malignant lymphoma, who underwent breast conservative surgery and ELIOT, were identified in our institution. Median age at diagnosis of lymphoma was 26 years (49% were less than 25). Median interval between lymphoma and breast cancer occurrence was 19 years. A total dose of 21 Gy (prescribed at 90% isodose) in 39 patients (91%), of 17 Gy (prescribed at 100% isodose) in 1 patient and 18 Gy (prescribed at 90% isodose), was delivered. ELIOT was well tolerated in all patients without any unusual acute or late reactions. After a median follow-up of 52 months, local recurrence occurred in 9% of the patients and metastases in 7% patients. Conclusion: In patients previously treated for lymphoma, partial breast irradiation, and in particular ELIOT, permits breast conservative surgery without acute local complications, decreasing the number of avoidable mastectomies.

Original languageEnglish
JournalBreast
Volume20
Issue numberSUPPL. 3
DOIs
Publication statusPublished - Oct 2011

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Survivors
Lymphoma
Breast Neoplasms
Breast
Mastectomy
Therapeutics
Radiation
Hodgkin Disease
Radiotherapy
Electrons
Neoplasm Metastasis
Recurrence
Neoplasms

Keywords

  • Breast cancer
  • ELIOT
  • Hodgkin's disease
  • Intraoperative radiotherapy
  • Lymphoma
  • Partial breast irradiation

ASJC Scopus subject areas

  • Surgery

Cite this

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title = "Local therapy for breast cancer in malignant lymphoma survivors",
abstract = "Summary: Aims: Breast cancer is the most frequent secondary tumor in young women previously treated with mantle radiation for Hodgkin's disease. Prior therapeutic radiation to the breast region is considered an absolute contraindication to breast conservative surgery, and mastectomy is considered the treatment of choice. We performed a retrospective review to assess the potential of performing breast conservative surgery and intraoperative radiotherapy with electrons (ELIOT), in these patients. Methods and results: Forty-three patients affected by early breast cancer, previously treated with mantle radiation for malignant lymphoma, who underwent breast conservative surgery and ELIOT, were identified in our institution. Median age at diagnosis of lymphoma was 26 years (49{\%} were less than 25). Median interval between lymphoma and breast cancer occurrence was 19 years. A total dose of 21 Gy (prescribed at 90{\%} isodose) in 39 patients (91{\%}), of 17 Gy (prescribed at 100{\%} isodose) in 1 patient and 18 Gy (prescribed at 90{\%} isodose), was delivered. ELIOT was well tolerated in all patients without any unusual acute or late reactions. After a median follow-up of 52 months, local recurrence occurred in 9{\%} of the patients and metastases in 7{\%} patients. Conclusion: In patients previously treated for lymphoma, partial breast irradiation, and in particular ELIOT, permits breast conservative surgery without acute local complications, decreasing the number of avoidable mastectomies.",
keywords = "Breast cancer, ELIOT, Hodgkin's disease, Intraoperative radiotherapy, Lymphoma, Partial breast irradiation",
author = "Mattia Intra and Denise Mattar and Claudia Sangalli and Nicole Rotmensz and Giuseppe Viale and Viviana Galimberti and Alberto Luini and Paolo Veronesi and Marco Colleoni and Stefano Zurrida and Roberto Orecchia and Umberto Veronesi",
year = "2011",
month = "10",
doi = "10.1016/S0960-9776(11)70304-6",
language = "English",
volume = "20",
journal = "Breast",
issn = "0960-9776",
publisher = "Churchill Livingstone",
number = "SUPPL. 3",

}

TY - JOUR

T1 - Local therapy for breast cancer in malignant lymphoma survivors

AU - Intra, Mattia

AU - Mattar, Denise

AU - Sangalli, Claudia

AU - Rotmensz, Nicole

AU - Viale, Giuseppe

AU - Galimberti, Viviana

AU - Luini, Alberto

AU - Veronesi, Paolo

AU - Colleoni, Marco

AU - Zurrida, Stefano

AU - Orecchia, Roberto

AU - Veronesi, Umberto

PY - 2011/10

Y1 - 2011/10

N2 - Summary: Aims: Breast cancer is the most frequent secondary tumor in young women previously treated with mantle radiation for Hodgkin's disease. Prior therapeutic radiation to the breast region is considered an absolute contraindication to breast conservative surgery, and mastectomy is considered the treatment of choice. We performed a retrospective review to assess the potential of performing breast conservative surgery and intraoperative radiotherapy with electrons (ELIOT), in these patients. Methods and results: Forty-three patients affected by early breast cancer, previously treated with mantle radiation for malignant lymphoma, who underwent breast conservative surgery and ELIOT, were identified in our institution. Median age at diagnosis of lymphoma was 26 years (49% were less than 25). Median interval between lymphoma and breast cancer occurrence was 19 years. A total dose of 21 Gy (prescribed at 90% isodose) in 39 patients (91%), of 17 Gy (prescribed at 100% isodose) in 1 patient and 18 Gy (prescribed at 90% isodose), was delivered. ELIOT was well tolerated in all patients without any unusual acute or late reactions. After a median follow-up of 52 months, local recurrence occurred in 9% of the patients and metastases in 7% patients. Conclusion: In patients previously treated for lymphoma, partial breast irradiation, and in particular ELIOT, permits breast conservative surgery without acute local complications, decreasing the number of avoidable mastectomies.

AB - Summary: Aims: Breast cancer is the most frequent secondary tumor in young women previously treated with mantle radiation for Hodgkin's disease. Prior therapeutic radiation to the breast region is considered an absolute contraindication to breast conservative surgery, and mastectomy is considered the treatment of choice. We performed a retrospective review to assess the potential of performing breast conservative surgery and intraoperative radiotherapy with electrons (ELIOT), in these patients. Methods and results: Forty-three patients affected by early breast cancer, previously treated with mantle radiation for malignant lymphoma, who underwent breast conservative surgery and ELIOT, were identified in our institution. Median age at diagnosis of lymphoma was 26 years (49% were less than 25). Median interval between lymphoma and breast cancer occurrence was 19 years. A total dose of 21 Gy (prescribed at 90% isodose) in 39 patients (91%), of 17 Gy (prescribed at 100% isodose) in 1 patient and 18 Gy (prescribed at 90% isodose), was delivered. ELIOT was well tolerated in all patients without any unusual acute or late reactions. After a median follow-up of 52 months, local recurrence occurred in 9% of the patients and metastases in 7% patients. Conclusion: In patients previously treated for lymphoma, partial breast irradiation, and in particular ELIOT, permits breast conservative surgery without acute local complications, decreasing the number of avoidable mastectomies.

KW - Breast cancer

KW - ELIOT

KW - Hodgkin's disease

KW - Intraoperative radiotherapy

KW - Lymphoma

KW - Partial breast irradiation

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U2 - 10.1016/S0960-9776(11)70304-6

DO - 10.1016/S0960-9776(11)70304-6

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JF - Breast

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