Local treatment with electrochemotherapy of superficial angiosarcomas: Efficacy and safety results from a multi-institutional retrospective study

Michele Guida, Luca Giovanni Campana, Pietro Curatolo, Sabino Strippoli, Antonio Bonadies, G. Grilz, Carlo Cabula, Roberta Rotunno, Stefania Bucher, Nicola Solari, A. Santoriello, Sara Valpione, Carlo Riccardo Rossi

Research output: Contribution to journalArticle

Abstract

Background: Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, exerting prominent cytotoxic activity, and antivascular effects. Its efficacy in angiosarcoma has not been investigated. Methods: This multicenter retrospective analysis reviewed patients who underwent electrochemotherapy from 2007 to 2014 for superficial advanced angiosarcomas. Bleomycin was administered intravenously and delivered within tumors by means of percutaneously applied electric pulses, according to the European Standard Operating Procedures for Electrochemotherapy. Tumor assessment was performed using RECIST (version 1.1). Toxicity (CTCAE, v4.0) and local progression-free survival (LPFS) were also evaluated. Results: Nineteen patients (13 with locally advanced and 6 with metastatic angiosarcomas) were treated. Tumor sites were: scalp (n = 5), breast (n = 8), other skin sites (n = 3), and soft tissue (n = 3). Target lesions (n = 54) ranged in size from 1.5 to 2.5 cm (median, 2 cm). Treatment was well tolerated. After 2 months, an objective response was observed in 12/19 (63%) patients, complete in 8 (42%). One-year LPFS within treatment field was 68%. Local symptom improvement included palliation of bleeding (5/19 patients) and pain relief (6/19 patients). Conclusions: Electrochemotherapy may represent a new locoregional treatment for selected patients with superficial angiosarcomas. J. Surg. Oncol. 2016;114:246–253. © 2016 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)246-253
Number of pages8
JournalJournal of Surgical Oncology
Volume114
Issue number2
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • bleomycin
  • drug delivery systems
  • electrochemotherapy
  • hemangiosarcoma
  • local
  • neoplasm recurrence
  • vascular neoplasms

ASJC Scopus subject areas

  • Surgery
  • Oncology

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