Localisation of intestinal gastrin in a distinct endocrine cell type [15]

A. M J Buchan, J. M. Polak, E. Solcia, A. G E Pearse

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

GASTRIN extracted from human intestine has two main molecular forms, little (G17) and big (G34) gastrins1. Both these peptides are also found in antral tissue although their relative proportions differ, G17 being the major component in antral tissue and G34 that in intestinal tissue1. The endocrine cell associated with the production of the immunoreactive gastrin found in the antral tissue is the ultrastructurally classified G cell 2. The cellular origin of the immunoreactive gastrin extracted from the intestinal tissue has not been determined. The presence of cholecystokinin (CCK) peptides3,4, closely related to gastrin and sharing with it a C-terminal pentapeptide sequence (see Fig. 1), makes the specific immunological detection of both gastrin and CCK dependent on the use of well characterised and highly specific antibodies. We report here the finding that intestinal gastrin originates in a type of cell totally distinct from the I cell which has recently been identified as the source of CCK5.

Original languageEnglish
Pages (from-to)138-140
Number of pages3
JournalNature
Volume277
Issue number5692
DOIs
Publication statusPublished - 1979

Fingerprint

Endocrine Cells
Gastrins
Tetragastrin
Gastrin-Secreting Cells
Cholecystokinin
Intestines
Peptides
Antibodies
Antral

ASJC Scopus subject areas

  • General

Cite this

Buchan, A. M. J., Polak, J. M., Solcia, E., & Pearse, A. G. E. (1979). Localisation of intestinal gastrin in a distinct endocrine cell type [15]. Nature, 277(5692), 138-140. https://doi.org/10.1038/277138a0

Localisation of intestinal gastrin in a distinct endocrine cell type [15]. / Buchan, A. M J; Polak, J. M.; Solcia, E.; Pearse, A. G E.

In: Nature, Vol. 277, No. 5692, 1979, p. 138-140.

Research output: Contribution to journalArticle

Buchan, AMJ, Polak, JM, Solcia, E & Pearse, AGE 1979, 'Localisation of intestinal gastrin in a distinct endocrine cell type [15]', Nature, vol. 277, no. 5692, pp. 138-140. https://doi.org/10.1038/277138a0
Buchan, A. M J ; Polak, J. M. ; Solcia, E. ; Pearse, A. G E. / Localisation of intestinal gastrin in a distinct endocrine cell type [15]. In: Nature. 1979 ; Vol. 277, No. 5692. pp. 138-140.
@article{d7d13d67778d4fd798c2ed7366e4df79,
title = "Localisation of intestinal gastrin in a distinct endocrine cell type [15]",
abstract = "GASTRIN extracted from human intestine has two main molecular forms, little (G17) and big (G34) gastrins1. Both these peptides are also found in antral tissue although their relative proportions differ, G17 being the major component in antral tissue and G34 that in intestinal tissue1. The endocrine cell associated with the production of the immunoreactive gastrin found in the antral tissue is the ultrastructurally classified G cell 2. The cellular origin of the immunoreactive gastrin extracted from the intestinal tissue has not been determined. The presence of cholecystokinin (CCK) peptides3,4, closely related to gastrin and sharing with it a C-terminal pentapeptide sequence (see Fig. 1), makes the specific immunological detection of both gastrin and CCK dependent on the use of well characterised and highly specific antibodies. We report here the finding that intestinal gastrin originates in a type of cell totally distinct from the I cell which has recently been identified as the source of CCK5.",
author = "Buchan, {A. M J} and Polak, {J. M.} and E. Solcia and Pearse, {A. G E}",
year = "1979",
doi = "10.1038/277138a0",
language = "English",
volume = "277",
pages = "138--140",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "5692",

}

TY - JOUR

T1 - Localisation of intestinal gastrin in a distinct endocrine cell type [15]

AU - Buchan, A. M J

AU - Polak, J. M.

AU - Solcia, E.

AU - Pearse, A. G E

PY - 1979

Y1 - 1979

N2 - GASTRIN extracted from human intestine has two main molecular forms, little (G17) and big (G34) gastrins1. Both these peptides are also found in antral tissue although their relative proportions differ, G17 being the major component in antral tissue and G34 that in intestinal tissue1. The endocrine cell associated with the production of the immunoreactive gastrin found in the antral tissue is the ultrastructurally classified G cell 2. The cellular origin of the immunoreactive gastrin extracted from the intestinal tissue has not been determined. The presence of cholecystokinin (CCK) peptides3,4, closely related to gastrin and sharing with it a C-terminal pentapeptide sequence (see Fig. 1), makes the specific immunological detection of both gastrin and CCK dependent on the use of well characterised and highly specific antibodies. We report here the finding that intestinal gastrin originates in a type of cell totally distinct from the I cell which has recently been identified as the source of CCK5.

AB - GASTRIN extracted from human intestine has two main molecular forms, little (G17) and big (G34) gastrins1. Both these peptides are also found in antral tissue although their relative proportions differ, G17 being the major component in antral tissue and G34 that in intestinal tissue1. The endocrine cell associated with the production of the immunoreactive gastrin found in the antral tissue is the ultrastructurally classified G cell 2. The cellular origin of the immunoreactive gastrin extracted from the intestinal tissue has not been determined. The presence of cholecystokinin (CCK) peptides3,4, closely related to gastrin and sharing with it a C-terminal pentapeptide sequence (see Fig. 1), makes the specific immunological detection of both gastrin and CCK dependent on the use of well characterised and highly specific antibodies. We report here the finding that intestinal gastrin originates in a type of cell totally distinct from the I cell which has recently been identified as the source of CCK5.

UR - http://www.scopus.com/inward/record.url?scp=0018787732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018787732&partnerID=8YFLogxK

U2 - 10.1038/277138a0

DO - 10.1038/277138a0

M3 - Article

C2 - 366436

AN - SCOPUS:0018787732

VL - 277

SP - 138

EP - 140

JO - Nature

JF - Nature

SN - 0028-0836

IS - 5692

ER -