Localization of β-defensin genes in non human primates

M. Ventura, M. Boniotto, M. Pazienza, V. Palumbo, M. F. Cardone, M. Rocchi, A. Tossi, A. Amoroso, Sergio Crovella

Research output: Contribution to journalArticle

Abstract

Defensins are a family of host defence peptides that play an important role in the innate immunity of mammalian and avian species. In humans, four β-defensins have been isolated so far, corresponding to the products of the genes DEFB1 (h-BD1, GenBank accession number NM_005218); DEFB4 (h-Bd2, NM_004942.2), DEFB103 (h-BD3, NM_018661); and DEFB104 (hBD4, NM_080389) mapping on chromosome 8p23.22. We have localized β-defensin genes on metaphasic chromosomes of great apes and several non-human primate species to determine their physical mapping. Using fluorescent in situ hybridization and BAC probes containing the four β-defensin genes, we have mapped the homologous regions to the β-defensin genes on chromosome 8p23-p.22 in non-human primates, while no signals were detected on prosimians chromosomes.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalEuropean journal of histochemistry : EJH
Volume48
Issue number2
Publication statusPublished - 2004

Keywords

  • FISH
  • Homology
  • Innate immunity
  • Molecular evolution

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Cell Biology
  • Developmental Biology
  • Anatomy

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  • Cite this

    Ventura, M., Boniotto, M., Pazienza, M., Palumbo, V., Cardone, M. F., Rocchi, M., Tossi, A., Amoroso, A., & Crovella, S. (2004). Localization of β-defensin genes in non human primates. European journal of histochemistry : EJH, 48(2), 195-199.