Localization of a gene for nonsyndromic renal hypodysplasia to chromosome 1p32-33

Simone Sanna-Cherchi, Gianluca Caridi, Patricia L. Weng, Monica Dagnino, Marco Seri, Anita Konka, Danio Somenzi, Alba Carrea, Claudia Izzi, Domenica Casu, Landino Allegri, Kai M. Schmidt-Ott, Jonathan Barasch, Francesco Scolari, Roberto Ravazzolo, Gian Marco Ghiggeri, Ali G. Gharavi

Research output: Contribution to journalArticle

Abstract

Nonsyndromic defects in the urinary tract are the most common cause of end-stage renal failure in children and account for a significant proportion of adult nephropathy. The genetic basis of these disorders is not fully understood. We studied seven multiplex kindreds ascertained via an index case with a nonsyndromic solitary kidney or renal hypodysplasia. Systematic ultrasonographic screening revealed that many family members harbor malformations, such as solitary kidneys, hypodysplasia, or ureteric abnormalities (in a total of 29 affected individuals). A genomewide scan identified significant linkage to a 6.9-Mb segment on chromosome 1p32-33 under an autosomal dominant model with reduced penetrance (peak LOD score 3.5 at D1S2652 in the largest kindred). Altogether, three of the seven families showed positive LOD scores at this interval, demonstrating heterogeneity of the trait (peak HLOD 3.9, with 45% of families linked). The chromosome 1p32-33 interval contains 52 transcription units, and at least 23 of these are expressed at stage E12.5 in the murine ureteric bud and/or metanephric mesenchyme. These data show that autosomal dominant nonsyndromic renal hypodysplasia and associated urinary tract malformations are genetically heterogeneous and identify a locus for this common cause of human kidney failure.

Original languageEnglish
Pages (from-to)539-549
Number of pages11
JournalAmerican Journal of Human Genetics
Volume80
Issue number3
DOIs
Publication statusPublished - Mar 2007

ASJC Scopus subject areas

  • Genetics

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    Sanna-Cherchi, S., Caridi, G., Weng, P. L., Dagnino, M., Seri, M., Konka, A., Somenzi, D., Carrea, A., Izzi, C., Casu, D., Allegri, L., Schmidt-Ott, K. M., Barasch, J., Scolari, F., Ravazzolo, R., Ghiggeri, G. M., & Gharavi, A. G. (2007). Localization of a gene for nonsyndromic renal hypodysplasia to chromosome 1p32-33. American Journal of Human Genetics, 80(3), 539-549. https://doi.org/10.1086/512248