Localization of a gene for partial epilepsy to chromosome 10q

Ruth Ottman, M. Vittoria Schiaffino, Alessandra Renieri, Filomena De Nigris, Lucia Galli, Mirella Bruttini, Marinella Gebbia, Arthur A B Bergen, Richard A. Lewis, Andrea Ballabio

Research output: Contribution to journalArticlepeer-review

Abstract

There is strong evidence for a genetic contribution to epilepsy, but it is commonly assumed that this genetic contribution is limited to ‘generalized’ epilepsies, and that most forms of ‘partial’ epilepsy are nongenetic. In a linkage analysis of a single family containing 11 affected individuals, we obtained strong evidence for localization of a gene for partial epilepsy. This susceptibility gene maps to chromosome 10q, with a maximum two–point lod score for D10S192 of 3.99 at θ=0.0. All affected individuals share a single haplotype for seven tightly linked contiguous markers; the maximum lod score for this haplotype is 4.83 at θ=0.0. Key recombinants place the susceptibility locus within a 10 centimorgan interval.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalNature Genetics
Volume10
Issue number1
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Medicine(all)
  • Genetics

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