Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset

Vincenzo Bonifati; Guido J. Breedveld; Ferdinando Squitieri; Nicola Vanacore; Pierluigi Brustenghi; Biswadjiet S. Harhangi; Pasquale Montagna; Milena Cannella; Giovanni Fabbrini; Patrizia Rizzu; Cornelia M. Van Duijn; Ben A. Oostra; Giuseppe Meco; Peter Heutink

doi:10.1002/ana.10106

Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset

Vincenzo Bonifati, Guido J. Breedveld, Ferdinando Squitieri, Nicola Vanacore, Pierluigi Brustenghi, Biswadjiet S. Harhangi, Pasquale Montagna, Milena Cannella, Giovanni Fabbrini, Patrizia Rizzu, Cornelia M. Van Duijn, Ben A. Oostra, Giuseppe Meco, Peter Heutink

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Abstract

Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.

Original language	English
Pages (from-to)	253-256
Number of pages	4
Journal	Annals of Neurology
Volume	51
Issue number	2
DOIs	https://doi.org/10.1002/ana.10106
Publication status	Published - 2002

ASJC Scopus subject areas

Neuroscience(all)

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Bonifati, V., Breedveld, G. J., Squitieri, F., Vanacore, N., Brustenghi, P., Harhangi, B. S., Montagna, P., Cannella, M., Fabbrini, G., Rizzu, P., Van Duijn, C. M., Oostra, B. A., Meco, G., & Heutink, P. (2002). Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset. Annals of Neurology, 51(2), 253-256. https://doi.org/10.1002/ana.10106

Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset. / Bonifati, Vincenzo; Breedveld, Guido J.; Squitieri, Ferdinando; Vanacore, Nicola; Brustenghi, Pierluigi; Harhangi, Biswadjiet S.; Montagna, Pasquale; Cannella, Milena ; Fabbrini, Giovanni; Rizzu, Patrizia; Van Duijn, Cornelia M.; Oostra, Ben A.; Meco, Giuseppe; Heutink, Peter.

In: Annals of Neurology, Vol. 51, No. 2, 2002, p. 253-256.

Research output: Contribution to journal › Article › peer-review

Bonifati, V, Breedveld, GJ, Squitieri, F, Vanacore, N, Brustenghi, P, Harhangi, BS, Montagna, P, Cannella, M , Fabbrini, G, Rizzu, P, Van Duijn, CM, Oostra, BA, Meco, G & Heutink, P 2002, 'Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset', Annals of Neurology, vol. 51, no. 2, pp. 253-256. https://doi.org/10.1002/ana.10106

Bonifati, Vincenzo ; Breedveld, Guido J. ; Squitieri, Ferdinando ; Vanacore, Nicola ; Brustenghi, Pierluigi ; Harhangi, Biswadjiet S. ; Montagna, Pasquale ; Cannella, Milena ; Fabbrini, Giovanni ; Rizzu, Patrizia ; Van Duijn, Cornelia M. ; Oostra, Ben A. ; Meco, Giuseppe ; Heutink, Peter. / Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset. In: Annals of Neurology. 2002 ; Vol. 51, No. 2. pp. 253-256.

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abstract = "Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.",

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AU - Rizzu, Patrizia

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AB - Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.

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Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset

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