Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset

Vincenzo Bonifati, Guido J. Breedveld, Ferdinando Squitieri, Nicola Vanacore, Pierluigi Brustenghi, Biswadjiet S. Harhangi, Pasquale Montagna, Milena Cannella, Giovanni Fabbrini, Patrizia Rizzu, Cornelia M. Van Duijn, Ben A. Oostra, Giuseppe Meco, Peter Heutink

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Abstract

Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalAnnals of Neurology
Volume51
Issue number2
DOIs
Publication statusPublished - 2002

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bonifati, V., Breedveld, G. J., Squitieri, F., Vanacore, N., Brustenghi, P., Harhangi, B. S., Montagna, P., Cannella, M., Fabbrini, G., Rizzu, P., Van Duijn, C. M., Oostra, B. A., Meco, G., & Heutink, P. (2002). Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset. Annals of Neurology, 51(2), 253-256. https://doi.org/10.1002/ana.10106