TY - JOUR
T1 - Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset
AU - Bonifati, Vincenzo
AU - Breedveld, Guido J.
AU - Squitieri, Ferdinando
AU - Vanacore, Nicola
AU - Brustenghi, Pierluigi
AU - Harhangi, Biswadjiet S.
AU - Montagna, Pasquale
AU - Cannella, Milena
AU - Fabbrini, Giovanni
AU - Rizzu, Patrizia
AU - Van Duijn, Cornelia M.
AU - Oostra, Ben A.
AU - Meco, Giuseppe
AU - Heutink, Peter
PY - 2002
Y1 - 2002
N2 - Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.
AB - Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.
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U2 - 10.1002/ana.10106
DO - 10.1002/ana.10106
M3 - Article
C2 - 11835383
AN - SCOPUS:0036151884
VL - 51
SP - 253
EP - 256
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 2
ER -